2020
DOI: 10.3390/biomedicines8100394
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Abstract: Astrocytes, the most numerous glial cells in the brains of humans and other mammalian animals, have been studied since their discovery over 100 years ago. For many decades, however, astrocytes were believed to operate as a glue, providing only mechanical and metabolic support to adjacent neurons. Starting from a “revolution” initiated about 25 years ago, numerous astrocyte functions have been reconsidered, some previously unknown, others attributed to neurons or other cell types. The knowledge of astrocytes ha… Show more

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Cited by 22 publications
(13 citation statements)
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References 101 publications
(159 reference statements)
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“…Astrocytes as the heterogeneous and most numerous cells of the brain, are the major controllers of synaptic activity and plasticity, neuronal network, and cognitive functions [ 102 , 103 ]. Being supportive glial components in neural tissue, they provide an adequate ionic milieu for neurons, support their metabolism, maintain the BBB, regulate blood flow, and clear cell debris, as reviewed by Kim et al [ 104 ].…”
Section: Functions Of Astrocytes Oligodendrocytes Microglia and Their Activationmentioning
confidence: 99%
“…Astrocytes as the heterogeneous and most numerous cells of the brain, are the major controllers of synaptic activity and plasticity, neuronal network, and cognitive functions [ 102 , 103 ]. Being supportive glial components in neural tissue, they provide an adequate ionic milieu for neurons, support their metabolism, maintain the BBB, regulate blood flow, and clear cell debris, as reviewed by Kim et al [ 104 ].…”
Section: Functions Of Astrocytes Oligodendrocytes Microglia and Their Activationmentioning
confidence: 99%
“…In AD, a decline in somatostatin expression in the anterior olfactory nucleus co-localizes with the accumulation of β-amyloid proteins [ 112 ]. Such quantitative and qualitative differences are also evident in non-neuronal cell populations [ 113 ]. A quantitative analysis of activated microglia and astrocytes in AD and PD patients along with age-matched healthy control individuals indicates an increase in activated microglia and astrocytes in both neurodegenerative conditions [ 60 ].…”
Section: Neurodegenerative Diseasesmentioning
confidence: 99%
“…The gut microbiota similarly affects astrocytes in both ageing and age-associated neurodegenerative diseases ( 7 ). Ageing can alter the normal function of astrocytes which reduces their ability to properly maintain a healthy CNS environment ( 8 ).…”
Section: Influence Of Ageing and Iga On Cns Disease Via The Microbiomementioning
confidence: 99%