Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

Amiri, Mahmood; Hosseinmardi, Narges; Bahrami, Fariba; Janahmadi, Mahyar

doi:10.1007/s10827-012-0432-6

Cited by 87 publications

(55 citation statements)

References 71 publications

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“…Interestingly, the relative efficacy of artificial neuron-glia networks vs. pure neuronal networks increases as the complexity of the network increases (Porto-Pazos et al, 2011), which is in agreement with the gradual increase of the astrocyte-neuron ratio of cells observed in the phylogeny as the nervous system complexity increases. In addition, astrocytes are able to change the threshold value controlling the transition of synchronous to asynchronous behavior among neurons (Amiri et al, 2013). In this way, changes in the interaction properties of astrocyte-neuron signaling lead to the emergence of synchronous/asynchronous patterns in neural responses, showing how astrocytes play a primary role in neuronal firing synchronicity and synaptic coordination (Amiri et al, 2013).…”

Section: Astrocyte Role In Cognitive Functions From In Vivo Data To mentioning

confidence: 99%

“…In addition, astrocytes are able to change the threshold value controlling the transition of synchronous to asynchronous behavior among neurons (Amiri et al, 2013). In this way, changes in the interaction properties of astrocyte-neuron signaling lead to the emergence of synchronous/asynchronous patterns in neural responses, showing how astrocytes play a primary role in neuronal firing synchronicity and synaptic coordination (Amiri et al, 2013). Artificial astrocytes through the activation of SICs in neurons participate directly in synaptic plasticity processes, synchronizing postsynaptic activity in neuron clusters and subsequently allow Spike-Timing-Dependent Plasticity based learning to occur at the associated synapses (Wade et al, 2011).…”

Section: Astrocyte Role In Cognitive Functions From In Vivo Data To mentioning

confidence: 99%

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Neuron-glia networks: integral gear of brain function

Perea

Sur

Araque

2014

Front. Cell. Neurosci.

193

121

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Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and homeostatic functions of the Nervous System; however, their participation in coding information and cognitive processes has been largely ignored. The strategic position of astrocyte processes facing synapses and the astrocyte ability to uptake neurotransmitters and release neuroactive substances, so-called “gliotransmitters”, provide the scenario for prolific neuron-astrocyte signaling. From studies at single-cell level to animal behavior, recent advances in technology and genetics have revealed the impact of astrocyte activity in brain function from cellular and synaptic physiology, neuronal circuits to behavior. The present review critically discusses the consequences of astrocyte signaling on synapses and networks, as well as its impact on neuronal information processing, showing that some crucial brain functions arise from the coordinated activity of neuron-glia networks.

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Section: Astrocyte Role In Cognitive Functions From In Vivo Data To mentioning

confidence: 99%

Section: Astrocyte Role In Cognitive Functions From In Vivo Data To mentioning

confidence: 99%

Neuron-glia networks: integral gear of brain function

Perea

Sur

Araque

2014

Front. Cell. Neurosci.

193

121

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“…In fact, most of the previous works about neurodynamics have discussed the neuron-coupled astrocyte model [30][31][32][33][34] and some results could be helpful to understand the occurrence of seizure-like behavior [35]. Based on the wellknown neuron models, networks with different topological connections have been set to investigate the synchronization stability [36,37], pattern selection, and mode transition in collective behaviors [38][39][40][41][42][43][44][45].…”

Section: Complexitymentioning

confidence: 99%

Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled Astrocyte

Guo

Tang

et al. 2017

Complexity

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Autapse connection is considered on a biological neuron coupled by astrocyte, and the effect of autapse driving-induced response in electrical activities is investigated. In this paper, a simple network is developed on the Hodgkin-Huxley (HH) neuron coupled by astrocyte and the autapse effect is also considered. The modulation of autapse connected to HH neuron can change the membrane potential by applying time-delayed feedback along a close loop. It is found that the self-adaption of autapse driving can make the network of neuron-astrocyte generate different modes of electrical activities, and oscillating behavior of Ca 2+ and IP 3 setting is controlled. This new network model can give potential understanding about self-adaption of neuron to external forcing when the coupling of astrocyte and autapse is considered.

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“…While the interest in understanding the biological operations and computational modeling of neuronastrocyte signaling is continuously increasing, the neuromorphic neuron-astrocyte cross-talk circuit is less studied [31,[34][35][36][37][38]. An increasing interest in neuron-astrocyte signaling has paralleled our development of neuromorphic circuits incorporating astrocytes [7].…”

Section: Introductionmentioning

confidence: 99%

An analog astrocyte–neuron interaction circuit for neuromorphic applications

Ranjbar

Amiri

2015

J Comput Electron

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Recent neurophysiologic findings have shown that astrocytes (the most abundant type of glial cells) are active partners in neural information processing and regulate the synaptic transmission dynamically. Motivated by these findings, in the present research, an analog neuromorphic circuit to study neuron-astrocyte signaling is presented. In this analog circuit, the firing dynamics of the neuron is described by Izhikevich neuron circuit and the Ca 2+ dynamics of a single astrocyte explained by a functional simplified model introduced by Montaseri et al. Using the proposed neuronastrocyte circuit, it is demonstrated that the proposed analog astrocyte is able to activate the analog neuron or change the neuron spiking frequency through bidirectional communication. This suggests that analog astrocyte is capable of modulating spike transmission frequency. Moreover, our results suggest that the analog circuit of neuron-astrocyte crosstalk produces diverse neural responses and therefore enhances the information processing capabilities of the neuromorphic circuits. This is suitable for applications in reconfigurable neuromorphic devices which implement biologically brain circuits.

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Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

Cited by 87 publications

References 71 publications

Neuron-glia networks: integral gear of brain function

Neuron-glia networks: integral gear of brain function

Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled Astrocyte

An analog astrocyte–neuron interaction circuit for neuromorphic applications

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