2010
DOI: 10.1007/s12032-010-9475-6
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Abstract: Astrocyte-elevated gene-1 (AEG-1) plays an important role in diverse cancers and its up-regulation is associated with poor survival of patients. However, the status of AEG-1 expression and its significance in gastric cancer are still unclear. In this study, the expression of AEG-1 was studied in different gastric cancer cell lines and gastric cancer tissues. Expression of AEG-1 was significantly higher in gastric cancer tissues than that in normal tissues. Overexpression of AEG-1 was found in 62.9% of gastric … Show more

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Cited by 86 publications
(86 citation statements)
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“…Xu et al . reported that AEG‐1 was involved in the Wnt/β–catenin signalling pathway for the growth and apoptosis of gastric cancer cells 40. Li et al .…”
Section: Discussionmentioning
confidence: 99%
“…Xu et al . reported that AEG‐1 was involved in the Wnt/β–catenin signalling pathway for the growth and apoptosis of gastric cancer cells 40. Li et al .…”
Section: Discussionmentioning
confidence: 99%
“…inducible gene in primary human fetal astrocytes (Kang et al, 2005), however the subsequent research demostrated that it expression is elevated in some solid tumors, including those of gynecologic tumors (breast, endometrial, and ovarian tumors) (Li et al, 2008;Song et al, 2010;, Gastrointestinal carcinoma ( hepatocellular and gallbladder, colon and gastric carcinomas ) (Song et al, 2010;Chen et al, 2011;Jianbo et al, 2011), head and neck cancers (Hui et al, 2011; as an important therapeutic target for simultaneously risk. Dramatically, Brown et al (2004) showed that strong MTDH staining was observed in 17 out of 31 samples of breast carcinoma patients while MTDH staining was absent in 18 out of 20 samples of normal breast tissue , this experiment disclosed that MTDH protein is overexpressed in metastatic breast cancer tissue ,and selectively targeted phage as well as cells to the lung, indicating that MTDH protein mediates localization at the metastatic site in breast cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Until now, over-expression of MTDH has been documented in different types of tumoral samples, including breast (Emdad et al, 2007), prostate (Kikuno et al, 2007), gastric (Jian-bo et al, 2010) and colorectal cancer (Song et al, 2010), mainly by immunohistochemistry (Sarkar et al, 2009). In breast (Li et al, 2008) and gastric cancer (Jian-bo et al, 2010), esophageal squamous cell carcinoma (Yu et al, 2009), non-small cell lung cancer (NSCLC) ) and hepatocellular carcinoma (Yoo et al, 2009), the level of upregulation correlates with clinical progression and poor prognosis of patients.…”
Section: Discussionmentioning
confidence: 99%
“…In breast (Li et al, 2008) and gastric cancer (Jian-bo et al, 2010), esophageal squamous cell carcinoma (Yu et al, 2009), non-small cell lung cancer (NSCLC) ) and hepatocellular carcinoma (Yoo et al, 2009), the level of upregulation correlates with clinical progression and poor prognosis of patients. Taken together, our results, in part, are in accord with Jian-Bo et al (2010) and the others as we also demonstrated that MTDH expression increased in human gastric cancer. However, we did not find any significant correlation between MTDH over-expression and tumor types and grades.…”
Section: Discussionmentioning
confidence: 99%
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