Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants.

Delfino, Ralph J.; Gong, Henry; Linn, William S.; Pellizzari, Edo D.; Hu, Yang

doi:10.1289/ehp.5992

Cited by 188 publications

(136 citation statements)

References 64 publications

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“…Three additional articles were excluded because they were not asthma-specific, but rather focused on respiratory symptoms (e.g., chest discomfort) or pulmonary function (Franklin et al 2000;Symington et al 1991;Wantke et al 1996). Two studies were excluded because, although asthma-specific, they did not contain a reference or control group (Delfino et al 2003;Erdei et al 2003). For the 10 articles included, we abstracted information regarding study design and setting, subject response/participation rates, definition of asthma (e.g., physician diagnosis), sample size, average (minimum and maximum) formaldehyde levels, average age of study subjects, and quantitative estimates (or raw data) for the association between formaldehyde exposure and asthma as well as whether such estimates were adjusted and, if so, for what measures (Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…It has been suggested that certain groups, specifically children, may be particularly sensitive to formaldehyde exposure; however, as with adults, the results have been inconsistent, with some studies reporting an association (Garrett et al 1999) and others not (Symington et al 1991). All of these studies have specific limi-tations including small sample sizes (Delfino et al 2003), the use of self-reported asthma (Smedje et al 1997), and potential selection bias (Garrett et al 1999). In addition, the extent of formaldehyde exposure varies widely across studies.…”

mentioning

confidence: 99%

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Formaldehyde exposure and asthma in children: a systematic review

McGwin

Lienert

Kennedy

2011

Ciênc. saúde coletiva

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Formaldehyde exposure and asthma in children: a systematic review Exposição ao formol e asma em crianças: uma revisão sistemáticaResumo Apesar de múltiplos estudos publicados sobre a associação entre exposição ao formol e asma infantil, uma relação consistente ainda não foi identificada. Nós relacionamos os resultados de revisão de estudos publicados a fim de fornecer uma imagem mais compreensível desta relação. Após pesquisa, foram identificados sete estudos que proviam resultados quantitativos sobre a associação entre a exposição ao formol e a asma infantil. Estudos foram heterogêneos em relação à definição de asma. Para cada estudo, uma razão de chances (RC) e 95% de intervalo de confiança (IC) para asma foram abstraídos de resultados publicados ou calculados baseados nos dados fornecidos. Foram usados modelos de efeitos fixos e aleatórios para calcular RC agrupados e IC de 95%; medidas de heterogeneidade também foram calculadas. Um modelo de efeitos fixos produziu um a RC de 1.03 (IC de 95%, 1.02-1.04), e o modelo de efeitos aleatórios produziu uma RC de 1.17 (IC de 95%, 1.01-1.36), ambos refletindo um aumento de 10 μg/m3 de exposição ao formol. As estatís-ticas de Q and I2 indicaram uma quantidade moderada de heterogeneidade. Resultados indicam uma associação positiva entre exposição ao formol e asma infantil. Devido à natureza de cruzamento de dados destes estudos por baixo desta meta-análise, um estudo de prospectiva epidemiológica mais aprofundada é necessário. Palavras-chave Asma, Crianças, Epidemiologia, Formol Abstract Despite multiple published studies regarding the association between formaldehyde exposure and childhood asthma, a consistent association has not been identified. Here we report the results of a systematic review of published literature in order to provide a more comprehensive picture of this relationship. After a literature search, we identified seven studies providing quantitative results regarding the association between formaldehyde exposure and asthma in children. Studies were heterogeneous with respect to the definition of asthma. For each study, an odds ratio (OR) and 95% confidence interval (CI) for asthma were abstracted from published results or calculated based on the data provided. We used fixed-and random-effects models to calculate pooled ORs and 95% CIs; measures of heterogeneity were also calculated. A fixed-effects model produced an OR of 1.03 (95% CI, 1.02-1.04), and random effects model produced an OR of 1.17 (95% CI, 1.01-1.36), both reflecting an increase of 10 μg/m3 of formaldehyde. Both the Q and I2 statistics indicated a moderate amount of heterogeneity. Results indicate a positive association between formaldehyde exposure and childhood asthma. Given the largely cross-sectional nature of the studies underlying this meta-analysis, further well-designed prospective epidemiologic studies are needed.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Formaldehyde exposure and asthma in children: a systematic review

McGwin

Lienert

Kennedy

2011

Ciênc. saúde coletiva

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“…Significant associations were mainly observed among symptomatic subjects. In this population, indoor particulate matter concentration has been related to a decrease in lung function, in particular among children with asthma [117][118][119][120] and, to a lesser extent, to an increased risk of asthmatic and bronchitis-like symptoms [121,122]. In a cohort of 150 asthmatic children, PM2.5 and PM2.5-10 concentrations, assessed three times every 3 months, were positively associated with the incidence rate of several respiratory symptoms, including cough, asthma symptoms and wheezing [121].…”

Section: Particulate Mattermentioning

confidence: 99%

Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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We reviewed the main epidemiological studies that evaluate the respiratory effects of indoor air pollutants quantitatively in industrialised countries. Consistent results support short-term (aggravation) and, although more rarely, long-term (prevalence augmentation) effects on asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) in indoor settings with poor air quality. Environmental tobacco smoke is one of the most important risks for respiratory symptoms and diseases worldwide. The evidence is also reliable for indoor nitrogen dioxide and particulate matter, which have been associated with asthma, bronchitis and COPD. Whereas formaldehyde and volatile organic compounds seem to be the main pollutants in indoor settings, relevant papers on their respiratory effects are still scarce, and limited to asthma and bronchitis. Moulds have been associated with an increased risk of asthma and COPD. Contradictory results have been found between endotoxins and asthma. The role of phthalates, persistent organic pollutants and flame retardants in respiratory diseases remains to be established. Results from rural areas of industrialised countries indicate that exposure to some indoor bio-contaminants might be protective in early life, while it is associated with adverse respiratory adverse effects in adulthood. Studies focusing on indoor air pollutants should be developed to better understand their involvement in the inception and aggravation of respiratory diseases.

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“…Though the roles of specific air pollutants on various respiratory illnesses remain unclear (Brunekreef et al, 1995, Delfino et al, 2003, the majority of earlier investigations considered air pollutants a risk factor for asthma. That is, the general effect of air pollution leads to adverse respiratory cases.…”

Section: Auto Correlation Analysesmentioning

confidence: 99%

Establishing the Association between Quarterly/Seasonal Air Pollution Exposure and Asthma using Geospatial Approach

Gorai¹,

Tuluri

Tchounwou

et al. 2015

Aerosol Air Qual. Res.

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Although it is known that air pollution may lead to increased asthma prevalence, no clear scientific evidence of direct association between air pollution and asthma rate has been reported. In the present study, a Geographical Information System (GIS) approach was developed to determine the association between asthma hospital discharge rate (ADR) and seasonal exposure to specific ambient air pollutants in eastern Texas, USA, during the period 2009 to 2011. Quarterly asthma data were obtained from Texas State Department of Health, National Asthma Survey surveillance of Texas State, USA. Quarterly mean concentrations of fine particular matter (PM 2.5 ), nitrogen dioxide (NO 2 ), and ozone (O 3 ) were determined from the corresponding measured daily data collected by various air quality monitoring stations distributed in different counties in the study area. Using Pearson correlation analysis, quarterly average of air pollutant concentrations was compared to quarterly Asthma discharge rate (ADR). The results revealed that the association between quarterly exposure of air pollution and ADR was not statistically significant in the study area. During the study period, a negative correlation coefficient was observed between the quarterly mean concentration of ozone and NO 2 with the quarterly ADR. However, in most of the cases a positive correlation coefficient was observed between the quarterly mean concentration of PM 2.5 and the quarterly ADR, indicating a probable association between ambient air pollution exposure and asthma prevalence.

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Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants.

Cited by 188 publications

References 64 publications

Formaldehyde exposure and asthma in children: a systematic review

Formaldehyde exposure and asthma in children: a systematic review

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Establishing the Association between Quarterly/Seasonal Air Pollution Exposure and Asthma using Geospatial Approach

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