Asthma: Prevalence, Pathogenesis, and Prospects for Novel Therapies

Transcriptome analysis in Takifugu rubripes and Dicentrarchus labrax gills during Cryptocaryon irritans infection

“…Meanwhile, activated IL‐1 , IL‐8 and TNF participate in various pathological processes such as inflammation and cancer (Kharman et al., 2013; Wagner & Nebreda, 2009). The high expression of AP‐1 is involved in the pathogenesis of bronchial asthma (Woodruff & Fahy, 2001). After infection with C. irritans , the host presents hypoxic symptoms of dyspnoea, we hypothesize that AP‐1 is involved in the physiological regulation of respiratory diseases.…”

Developing a tissue-engineered model of the human bronchiole

“…Neither the initiation and progression of airway remodelling nor its contribution to irreversible airway obstruction in asthma is well defined. Biopsies almost always reveal airway remodelling associated with asthma (Woodruff and Fahy, 2001); however, it is not always clinically demonstrated (Beasley et al , 2002). The severity of asthma varies so greatly that with its onset, the clinical evidence of remodelling can occur after only a few months or as much as several decades later (Beasley et al , 2002).…”

Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study

“…1,2,28,29 Infants of atopic parents who have early wheezing episodes or recurrent chest infections are often given diagnoses of infantile asthma. 7,8 They might be treated with corticosteroids or an inhaled bronchodilator.…”