Asthma in exercising children exposed to ozone: a cohort study

McConnell, Rob; Berhane, Kiros; Gilliland, Frank D.; London, Stephanie J.; Islam, Talat; Gauderman, W. James; Avol, Edward L.; Margolis, Helene G.; Peters, John

doi:10.1016/s0140-6736(02)07597-9

Cited by 666 publications

(429 citation statements)

References 28 publications

Supporting

Mentioning

391

Contrasting

Unclassified

Order By: Relevance

“…We focused on short term mortality increases due to increased ozone, but other important but less severe health conditions that are known to be influenced by short term increases in ozone include hospitalization for asthma and other chronic respiratory disease, lost work and school days due to respiratory symptoms. The adverse health consequences of chronic elevated ozone exposure on health is less well-studied although an expanding literature suggests such exposure increase the prevalence of asthma and asthma symptoms (McConnell 2002, Lin 2008.…”

Section: Research Gaps and Recommendations For Future Researchmentioning

confidence: 99%

Public health impacts of climate change in Washington State: projected mortality risks due to heat events and air pollution

et al. 2010

View full text Add to dashboard Cite

C limate change is likely to have serious and long-term consequences for public health. Among these are illness and mortality related to heat and worsening air quality In this study we examined the historical relationship between age-and cause-specific mortality rates and heat events at the 99 th percentile of humidex values in the greater Seattle area (King, Pierce and Snohomish counties), Spokane County, the Tri-Cities (Benton and Franklin counties) and Yakima County from 1980 through 2006; the relative risk of mortality during heat events compared with more temperate periods were then applied to population and climate projections for Washington State to calculate number of deaths above the baseline expected to occur during projected heat events in 2025, 2045 and 2085. We also estimated excess deaths due to ground-level ozone concentrations for mid century (2045)(2046)(2047)(2048)(2049)(2050)(2051)(2052)(2053)(2054) in King and Spokane counties. Estimates were based on current (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006) ozone measurements and mid-21 st century ozone projections, using estimates from the scientific literature to determine the effect of ozone on overall and cardiopulmonary mortality. For the historical heat analysis, relative risks derived for the greater Seattle area showed a significant dose-response relationship between duration of the heat event and the daily mortality rate for non-traumatic deaths for persons aged 45 and above, typically peaking at four days of exposure to humidex values above the 99 th percentile. Three different warming scenarios were considered, including high, low and moderate estimates. In the greater Seattle area, the largest number of excess deaths in all years and scenarios was predicted for persons aged 65 and above. Under the middle scenario, this age group is expected to have 96 excess deaths in 2025, 148 excess deaths in 2045 and 266 excess deaths in 2085 from all non-traumatic causes. Daily maximum 8 hour ozone concentrations are forecasted to be 16-28% higher in the mid 21 st century [1997][1998][1999][2000][2001][2002][2003][2004][2005][2006]. We estimated that the total non-traumatic ozone mortality rate by mid-century for King County would increase from baseline (0.026 per 100,000; 95% confidence interval 0.013-0.038) to 0.033 (0.017-0.049). For the same health outcome in Spokane County, the baseline period rate was 0.058 (0.030-0.085) and increased to 0.068 (0.035 -0.100) by mid-century. The cardiopulmonary death rate per 100,000 due to ozone was estimated to increase from 0.011 (0.005-0.017) to 0.015 (0.007-0.022) in King County, and from 0.027 (0.013-0.042) to 0.032 (0.015-0.049) in Spokane County. Public health interventions aimed at protecting Washington's population from excessive heat and increased ozone concentrations will become increasingly important for preventing deaths, especially among older adults. Furthermore, heat and air quality related illnesses that do not result in death, but are serious nevertheless, may be r...

show abstract

Section: Research Gaps and Recommendations For Future Researchmentioning

confidence: 99%

Public health impacts of climate change in Washington State: projected mortality risks due to heat events and air pollution

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Mexico City has the highest ozone concentrations in North America and ozone has been related to development of asthma. 25 We obtained measurements of ambient ozone from the Mexican government's air monitoring stations. Ozone levels were measured via UV photometry (analyzer-model 400; API, San Diego, CA, USA).…”

Section: Study Design and Subject Enrollmentmentioning

confidence: 99%

Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy

Romieu

Sienra-Monge

et al. 2008

Genes Immun

View full text Add to dashboard Cite

G-protein-coupled receptor for asthma susceptibility (GPRA or GPR154) was identified as an asthma and atopy candidate gene by positional cloning. Some subsequent studies suggest associations of GPRA single nucleotide polymorphisms (SNPs) and haplotypes with asthma or atopy susceptibility. However, the associated SNPs or haplotypes vary among studies. The role of GPRA genetic variation in asthma and atopy remains unsolved. Published data on GRPA variants and asthma come exclusively from Caucasian and Asian populations. We examined whether GPRA SNPs and haplotypes are associated with asthma and atopy in a Mexican population. We genotyped and analyzed 27 GPRA SNPs in 589 nuclear families consisting of asthmatic children aged 4-17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests to 25 aeroallergens. The 27 SNPs examined provided excellent coverage of the GPRA gene. GPRA SNPs and haplotypes were not associated with childhood asthma and the degree of atopy to aeroallergens in a Mexican population. Our review of studies of GPRA variants in relation to asthma phenotypes shows considerable heterogeneity. Accordingly, our results suggest that GPRA variants are not an important contributor to childhood asthma and atopy susceptibility in a Mexican population.

show abstract

“…The study originally comprised 12 southern California communities with 5762 participants (79% participation rate) (McConnell, Berhane, Gilliland, London, Islam, Gauderman et al, 2002b) (See Figure 1 for map of community and respondent locations). Children in the 4 th , 7 th and 10 th grades were recruited in 1993 and 1996 and followed through high school graduation.…”

Section: Study Design and Subjectsmentioning

confidence: 99%

“…Children in the 4 th , 7 th and 10 th grades were recruited in 1993 and 1996 and followed through high school graduation. Associations of asthma with housing characteristics, obesity, air pollution, family history and exercise have been previously described (Gauderman, Avol, Lurmann, Kuenzli, Gilliland, Peters et al, 2005;Gilliland, Berhane, Islam, McConnell, Gauderman, Gilliland et al, 2003;Kunzli, McConnell, Bates, Bastain, Hricko, Lurmann et al, 2003;London, James Gauderman, Avol, Rappaport, & Peters, 2001;McConnell, Berhane, Gilliland, Islam, Gauderman, London et al, 2002a;McConnell, Berhane, Gilliland et al, 2002b;McConnell, Berhane, Yao, Jerrett, Lurmann, Gilliland et al, 2006). A detailed description of the selection of communities, subject recruitment, and survey methods to assess demographic, household, activity, and baseline medical characteristics has also been reported (Peters, Avol, Navidi, London, Gauderman, Lurmann et al, 1999).…”

Section: Study Design and Subjectsmentioning

confidence: 99%

The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children

Shankardass

McConnell

Milam

et al. 2007

Social Science & Medicine

Self Cite

View full text Add to dashboard Cite

Spatial variation in childhood asthma and a recent increase in prevalence indicate that environmental factors play a significant role in the etiology of this important disease. Socioeconomic position (SEP) has been associated inversely and positively with childhood asthma. These contradictory results indicate a need for systematic research about SEP and asthma. Pathways have been suggested for effects of SEP on asthma at both the individual and community level. We examined the relationship of prevalent asthma to community-level indicators of SEP among 5762 children in 12 Southern California, using a multilevel random effects model. Estimates of community-level SEP were derived by summarizing census block group-level data using a novel method of weighting by the proportion of the block groups included in a community-specific bounding rectangle that contained 95% of local study subjects. Community © 2007 Elsevier Ltd. All rights reserved.Corresponding Author: shankard@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript characteristics included measures of male unemployment, household income, low education (i.e. no high school diploma), and poverty. There was a consistent inverse association between male unemployment and asthma across the inter-quartile range of community unemployment rates, indicating that asthma rates increase as community SEP increases. The results were robust to individual-level confounding, methods for summarizing census block group data to the community level, scale of analysis (i.e. community-level vs. neighborhood-level) and the modeling algorithm. The positive association between SEP and prevalent childhood asthma might be explained by differential access to medical care that remains unmeasured, by the hygiene hypothesis (e.g. lower SES may associate with higher protective exposures to endotoxin in early life), or by SEP acting as a proxy for unmeasured neighborhood characteristics.

show abstract

Asthma in exercising children exposed to ozone: a cohort study

Cited by 666 publications

References 28 publications

Public health impacts of climate change in Washington State: projected mortality risks due to heat events and air pollution

Public health impacts of climate change in Washington State: projected mortality risks due to heat events and air pollution

Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy

The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children

Contact Info

Product

Resources

About