Asthma Control Test Is Correlated to FEV₁and Nitric Oxide in Greek Asthmatic Patients: Influence of Treatment

Abstract

Although FEV(1) remains the main objective parameter for evaluating asthma, ACT score was found to reflect lung function and inflammation in a Greek asthmatic population.

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

“…87 In a study of patients with established stable asthma without recent exacerbations, FeNO had AUC of 0.79 for the identification of not well-controlled asthma (determined by ACT following GINA cutoffs). 79 AUC was, however, lower in those who smoked (smokers on ICS with FeNO cutoff of > 23 ppb had AUC of 0.60; and smokers not on ICS with FeNO cutoff of > 19 pbb had AUC of 0.68). 79 FeNO values >30 ppb were associated with positive predictive values > 0.85, indicating a status of not well-controlled asthma (except in smokers).…”

“…79 AUC was, however, lower in those who smoked (smokers on ICS with FeNO cutoff of > 23 ppb had AUC of 0.60; and smokers not on ICS with FeNO cutoff of > 19 pbb had AUC of 0.68). 79 FeNO values >30 ppb were associated with positive predictive values > 0.85, indicating a status of not well-controlled asthma (except in smokers). 79 In a study with older population (ages>65 years), FeNO values were statistically significantly higher in those with uncontrolled asthma than those with controlled/partly controlled (regardless of whether asthma control was determined using GINA control criteria or using ACT with a cutoff of 19).…”

“…79 FeNO values >30 ppb were associated with positive predictive values > 0.85, indicating a status of not well-controlled asthma (except in smokers). 79 In a study with older population (ages>65 years), FeNO values were statistically significantly higher in those with uncontrolled asthma than those with controlled/partly controlled (regardless of whether asthma control was determined using GINA control criteria or using ACT with a cutoff of 19). 80 The association between asthma control and FeNO was weakened in patients on ICS as observed in four studies.…”

“…80 The association between asthma control and FeNO was weakened in patients on ICS as observed in four studies. 79,[81][82][83] In addition, pregnant women who had monthly FeNO measurements showed a weak correlation between FeNO and ACT and wide variation in FeNO values. Results were the same in atopic and non atopic women.…”

The Interpretation of Exhaled Nitric Oxide Values in Children With Asthma Depends on the Degree of Bronchoconstriction and the Levels of Asthma Severity

“…Moreover, there is no general consensus about correlation between F ENO and respiratory function in children. 2,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] The main limitation of our study is the retrospective design. We gathered data from the subjects' medical documentation, which could partly have influenced the accuracy of our results.…”