Asthma

Patadia, Monica; Murrill, Lauren L.; Corey, Jacquelynne P.

doi:10.1016/j.otc.2013.10.001

Cited by 27 publications

(12 citation statements)

References 22 publications

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“…Nevertheless, the symptomatology is quite similar with respect to the severity of the disease with episodes and extent of exacerbation presenting with various degrees of exaggeration of symptoms. e four most common symptoms in asthmatics are wheeze, cough, shortness of breath or difficulty breathing, and varied sensation of chest tightness [144]. On physical examination, high-pitched, musical wheezes are vital signs though not specific in asthmatics.…”

Section: Clinical Presentation Of Covid-19 In Asthmaticsmentioning

confidence: 99%

Asthma and COVID-19: Emphasis on Adequate Asthma Control

Nassoro

Mujwahuzi

Mwakyula

et al. 2021

Canadian Respiratory Journal

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Asthmatics are at an increased risk of developing exacerbations after being infected by respiratory viruses such as influenza virus, parainfluenza virus, and human and severe acute respiratory syndrome coronaviruses (SARS-CoV). Asthma, especially when poorly controlled, is an independent risk factor for developing pneumonia. A subset of asthmatics can have significant defects in their innate, humoral, and cell-mediated immunity arms, which may explain the increased susceptibility to infections. Adequate asthma control is associated with a significant decrease in episodes of exacerbation. Because of their wide availability and potency to promote adequate asthma control, glucocorticoids, especially inhaled ones, are the cornerstone of asthma management. The current COVID-19 pandemic affects millions of people worldwide and possesses mortality several times that of seasonal influenza; therefore, it is necessary to revisit this subject. The pathogenesis of SARS-CoV-2, the virus that causes COVID-19, can potentiate the development of acute asthmatic exacerbation with the potential to worsen the state of chronic airway inflammation. The relationship is evident from several studies that show asthmatics experiencing a more adverse clinical course of SARS-CoV-2 infection than nonasthmatics. Recent studies show that dexamethasone, a potent glucocorticoid, and other inhaled corticosteroids significantly reduce morbidity and mortality among hospitalized COVID-19 patients. Hence, while we are waiting for more studies with higher level of evidence that further narrate the association between COVID-19 and asthma, we advise clinicians to try to achieve adequate disease control in asthmatics as it may reduce incidences and severity of exacerbations especially from SARS-CoV-2 infection.

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Section: Clinical Presentation Of Covid-19 In Asthmaticsmentioning

confidence: 99%

Asthma and COVID-19: Emphasis on Adequate Asthma Control

Nassoro

Mujwahuzi

Mwakyula

et al. 2021

Canadian Respiratory Journal

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“…1 Asthma is a heterogeneous disorder caused by various factors, such as allergies and air pollution, and is closely associated with inflammation and airway constriction. 2 , 3 Currently, although many drugs were applied for asthma treatment, the outcome of asthma treatment still is unsatisfactory. 4 Glucocorticoid‐induced transcript 1 gene (GLCCI1) was first described as a thymocyte‐specific transcript; the polymorphism of it was proved to be involved in the response to inhaled corticosteroids in asthmatic patients.…”

Section: Introductionmentioning

confidence: 99%

GLCCI1 reduces collagen deposition and airway hyper‐responsiveness in a mouse asthma model through binding with WD repeat domain 45B

Xun

Kuang

Yang

et al. 2021

J Cellular Molecular Medi

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Asthma is a serious public health problem globally, and the major types of it include allergic asthma, non-allergic asthma, late-onset asthma, fixed airflow-related asthma and obesity-related asthma. In accordance with the data from the World Health Organization, about 235 million people are affected by asthma worldwide. 1 Asthma is a heterogeneous disorder caused by various factors, such as allergies and air pollution, and is closely associated with inflammation and airway constriction. 2,3 Currently, although many drugs were applied for asthma treatment, the outcome of asthma treatment still is unsatisfactory. 4 Glucocorticoid-induced transcript 1 gene (GLCCI1) was first described as a thymocyte-specific transcript; the polymorphism of it was proved to be involved in the response to inhaled corticosteroids in asthmatic patients. 5,6 Some previous evidence has indicated that the polymorphisms of GLCCI1 are associated with the airway

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“…However, the health care cost for management of asthma is still very high; a major share of the morbidity and mortality associated with asthma is due to improper drug administration, unavailability of drugs, noncompliance by the patients, drug side-effects (specifically with steroids), misconceptions about the disease, cultural beliefs, device-related mishaps, and underlying undiagnosed comorbid [ 5 ]. Predisposing factors including smoking, obesity, poverty, residence in a high pollution zone, and malnutrition all contribute to poor outcomes as well [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Vitamin D Deficiency in Patients of Asthma

Alvi

Syed

Nusrat

et al. 2021

Cureus

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IntroductionAsthma is a clinical syndrome characterized by reversible and recurrent airway obstruction leading to the symptoms of wheezing, cough, shortness of breath, fatigue, and respiratory distress. It is one of the most common lung pathologies worldwide. Its incidence is on the rise in Pakistan, which may be due to overt environmental pollution or improving screening protocols. Irrespective more and more patients are now being diagnosed as cases of asthma and this has led to renewed interest in research for the subject locally.Vitamin D plays a key component of the immune system and its deficiency has been associated with diseases, such as inflammatory bowel disease, celiac disease, rheumatoid arthritis, depression, sepsis, and coronavirus disease 2019 (COVID-19) pneumonia. The role of vitamin D in exacerbation, prevention, causation, and treatment of asthma is still up for debate. However, as more data emerges, it is becoming evident that vitamin D in one way or another is linked to outcomes in asthma. Especially the deficiency of vitamin D in asthma and its supplementation has garnered great attention in scientific trials. Our research is just one small step in this direction. This study aims to evaluate the frequency of vitamin D deficiency in patients with asthma. MethodsThis was a retrospective cross-sectional cohort conducted at the Department of Medicine of Abbasi Shaheed Hospital Karachi (ASHK) during March 2019 to August 2019. Patients of either gender aged ≥18 years that were diagnosed with cases of asthma were eligible to be included in the study. Asthma was defined in accordance with the latest guidelines issued by the Pakistan Chest Society. A vitamin D level of <20 ng/dl was considered deficient. Patient confidentiality was made certain. ResultsA total of 97 (62.98%) of the 154 patients included in the study had <20 ng/ml of vitamin D level. The mean vitamin D level recorded in this study was 15.34±4.21 ng/dl. The male-to-female ratio was 1:5. The mean age of our cohort was 42.78±4.56 years. The mean duration of disease, i.e., asthma was 6.7±3.68 years. Both the age of the patients and duration of the disease were found to be statistically significant with respect to vitamin D levels in asthmatics. ConclusionsThe frequency of vitamin D deficiency is very high in patients with asthma. These suboptimal levels are significantly influenced by the age of the patient and the duration of the disease.

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Asthma

Cited by 27 publications

References 22 publications

Asthma and COVID-19: Emphasis on Adequate Asthma Control

Asthma and COVID-19: Emphasis on Adequate Asthma Control

GLCCI1 reduces collagen deposition and airway hyper‐responsiveness in a mouse asthma model through binding with WD repeat domain 45B

Frequency of Vitamin D Deficiency in Patients of Asthma

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