Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis

Sudharshan, S. J.; Veerabhadrappa, Bhavana; Subramaniyan, Subasri; Dyavaiah, Madhu

doi:10.1093/femsyr/foy113

Cited by 14 publications

(21 citation statements)

References 49 publications

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“…The mitochondrial fission proteins Dnm1 and Mdv1 appeared to promote AA-CD, as dnm1 Δ and mdv1 Δ strains displayed a resistant phenotype as evidenced by increased clonogenic survival and FUN-1 processing ability in comparison with the wild-type strain ( Fannjiang et al, 2004 ). On the other hand, ablation of a mitochondrial fission factor required for Dnm1p recruitment, Fis1p, resulted in sensitivity to this stressor, with a significant decrease in cell viability and an increase in PS exposure and chromatin condensation ( Fannjiang et al, 2004 ; Sj et al, 2019 ). However, the same group found that the phenotypes encountered in acetic acid-challenged fis1 Δ cells are a consequence of secondary mutations in WHI2 ( Cheng et al, 2008 ) and SIN3 genes ( Teng et al, 2013 ).…”

Section: Genetic Modulation Of Acetic Acid-induced Regulated Cell Deathmentioning

confidence: 99%

Regulation of Cell Death Induced by Acetic Acid in Yeasts

Chaves

Rego

Martins

et al. 2021

Front. Cell Dev. Biol.

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Acetic acid has long been considered a molecule of great interest in the yeast research field. It is mostly recognized as a by-product of alcoholic fermentation or as a product of the metabolism of acetic and lactic acid bacteria, as well as of lignocellulosic biomass pretreatment. High acetic acid levels are commonly associated with arrested fermentations or with utilization as vinegar in the food industry. Due to its obvious interest to industrial processes, research on the mechanisms underlying the impact of acetic acid in yeast cells has been increasing. In the past twenty years, a plethora of studies have addressed the intricate cascade of molecular events involved in cell death induced by acetic acid, which is now considered a model in the yeast regulated cell death field. As such, understanding how acetic acid modulates cellular functions brought about important knowledge on modulable targets not only in biotechnology but also in biomedicine. Here, we performed a comprehensive literature review to compile information from published studies performed with lethal concentrations of acetic acid, which shed light on regulated cell death mechanisms. We present an historical retrospective of research on this topic, first providing an overview of the cell death process induced by acetic acid, including functional and structural alterations, followed by an in-depth description of its pharmacological and genetic regulation. As the mechanistic understanding of regulated cell death is crucial both to design improved biomedical strategies and to develop more robust and resilient yeast strains for industrial applications, acetic acid-induced cell death remains a fruitful and open field of study.

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Section: Genetic Modulation Of Acetic Acid-induced Regulated Cell Deathmentioning

confidence: 99%

Regulation of Cell Death Induced by Acetic Acid in Yeasts

Chaves

Rego

Martins

et al. 2021

Front. Cell Dev. Biol.

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“…Nakaya et al, [42] assayed Beauveriolide I isolated from mushroom or Sunthonkun et al, [40] examined anti-aging of pigmented rice. In addition, other compounds including Dimethylchalcone, Cucurbitacin B, and Astaxanthine was exhibited antiaging activity in S. cerevisiae through CLS analysis [14][15][16].…”

Section: Cls Methods Using Tpc Analysismentioning

confidence: 99%

“…Lin et al, [15] reported anti-aging activity of Cucurbitacin B through regulating autophagy and oxidative stress in S. cerevisiae. In addition, Sudharsan et al, [16] also succeded to uncover the anti-aging mechanism of Astaxanthin in this yeast by decreasing oxidative stress and apoptosis mechanisms.…”

Section: Introductionmentioning

confidence: 99%

The Budding Yeast Saccharomyces cerevisiae as a Valuable Model Organism for Investigating Anti-Aging Compounds

Sudiyani¹,

Prastya²,

Maryana³

et al. 2021

Saccharomyces

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Saccharomyces cerevisiae, the budding yeast was long history as industrial baker’s yeast due to its ability to produce numerous product such as ethanol, acetate, industrial bakers etc. Interestingly, this yeast was also important tools for studying biological mechanism in eukaryotic cells including aging, autophagy, mitochondrial response etc. S. cerevisiae has arisen as a powerful chemical and genetic screening platform, due to a rapid workflow with experimental amenability and the availability of a wide range of genetic mutant libraries. Calorie restriction (CR) as the reduction of nutrients intake could promote yeast longevity through some pathways such as inhibition of nutrient sensing target of rapamycin (TOR), serine–threonine kinase (SCH9), protein adenylate cyclase (AC), protein kinase A (PKA) and ras, reduced ethanol, acetic acid and apoptotic process. In addition, CR also induces the expression of antioxidative proteins, sirtuin2 (Sir2), autophagy and induction of mitochondrial yeast adaptive response. Three methods, spotting test; chronological life span (CLS) and replicative life span (RLS) assays, have been developed to study aging in S. cerevisiae. Here, we present strategies for pharmacological anti-aging screens in yeast, discuss common pitfalls and summarize studies that have used yeast for drug discovery.

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“…Another xanthophyll astaxanthin (30 μM) increased the chronological lifespan of wild-type S. cerevisiae strains [ 350 ]. The positive effects were also observed on antioxidant ( sod1 Δ, sod2 Δ, tsa1 Δ, cta1 Δ) and anti-apoptotic (pep4Δ, fis1Δ) deficient S. cerevisiae strains.…”

Section: Terpenoids As Potential Geroprotectorsmentioning

confidence: 99%

“…A 2-h pretreatment with astaxanthin (30 μM) decreased sensitivity of S. cerevisiae antioxidant deficient strains ( sod1 Δ, sod2 Δ, tsa1 Δ, cta1 Δ, ctt1 Δ) to oxidative stress induced by H 2 O 2 [ 350 ]. The positive effect was accompanied by the decreased levels of ROS and lipid peroxidation as well as an increased level of glutathione (GSH) in all studied antioxidant deficient strains.…”

Section: Terpenoids As Potential Geroprotectorsmentioning

confidence: 99%

Terpenoids as Potential Geroprotectors

et al. 2020

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Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.

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Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis

Cited by 14 publications

References 49 publications

Regulation of Cell Death Induced by Acetic Acid in Yeasts

Regulation of Cell Death Induced by Acetic Acid in Yeasts

The Budding Yeast Saccharomyces cerevisiae as a Valuable Model Organism for Investigating Anti-Aging Compounds

Terpenoids as Potential Geroprotectors

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