Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats

Otton, Rosemari; Marin, Douglas Popp; Bolin, Anaysa Paola; Santos, Rita de Cassia Macedo dos; Polotow, Tatiana G.; Sampaio, Sandra Coccuzzo; Barros, Marcelo P.

doi:10.1016/j.cbi.2010.05.011

Cited by 75 publications

(51 citation statements)

References 46 publications

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“…Based on the strong correlation between oxidative stress and immune dysfunction in diabetic patients, Otton et al [62] recently studied the antioxidant effects of astaxanthin in the reactive oxygen/nitrogen species metabolism of lymphocytes isolated from alloxan-induced diabetic rats. The results showed that astaxanthin could be a good adjuvant in prophylaxis or recovery of lymphocyte dysfunctions associated with diabetic patients, especially when focusing on the re-establishment of the redox balance and a hypothetical antiapoptotic effect in lymphocytes [62].…”

Section: Diabetesmentioning

confidence: 98%

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Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

543

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

show abstract

Section: Diabetesmentioning

confidence: 98%

“…The results showed that astaxanthin could be a good adjuvant in prophylaxis or recovery of lymphocyte dysfunctions associated with diabetic patients, especially when focusing on the re-establishment of the redox balance and a hypothetical antiapoptotic effect in lymphocytes [62].…”

Section: Diabetesmentioning

confidence: 99%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

543

309

View full text Add to dashboard Cite

show abstract

“…• and O 2 •− and reducing the cytosolic Ca 2+ [17].In diabetes, major damage occurs in tissues such as kidney, astaxanthin can protect cell damages in thediabetic kidney [18]. In the kidneys of astaxanthin fed diabetic mice, cells positive for 8-hydroxydeoxyguanosine(8-OHdG), an index of oxidative stress, were significantly decreased, thus leading to the prevention of diabetic nephropathy [15].…”

Section: Astaxanthin and Diabetesmentioning

confidence: 97%

Astaxanthin in Disease Prevention and Treatment

Wang¹,

Zhao²

2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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“…Based on the strong correlation between oxidative stress and immune dysfunction in diabetic patients,Otton et al 50 recently studied the antioxidant effects of astaxanthin in the reactive oxygen/nitrogen species metabolism of lymphocytes isolated from alloxan-induced diabetic rats. The results showed that astaxanthin could be a good adjuvant in prophylaxis or recovery of lymphocyte dysfunctions associated with diabetic patients, especially when focusing on the reestablishment of the redox balance and a hypothetical antiapoptotic effect in lymphocytes 50 .…”

Section: Astaxanthin As Powerful Antioxidantmentioning

confidence: 99%

Untitled

2012

IJPSR

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Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources of the pigment has increased substantially.

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Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats

Cited by 75 publications

References 46 publications

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Astaxanthin in Disease Prevention and Treatment

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