Astaxanthin addition improves human neutrophils function: in vitro study

Abstract

Taken together our results are supportive to a beneficial effect of astaxanthin-treatment on human neutrophils function as demonstrated by increased phagocytic and fungicide capacity as well as by the reduced superoxide anion and hydrogen peroxide production, however, without affecting neutrophils capacity to kill C. albicans. This process appears to be mediated by calcium released from intracellular storages as well as nitric oxide production.

Impact of the carotenoid astaxanthin on phagocytic capacity and ROS/RNS production of human neutrophils treated with free fatty acids and high glucose

“…ASTA addition significantly improves phagocytic capacity of neutrophils treated with glucose and FFA. A similar result was obtained by our group previously [30]. Long-chain FFA and some of their derivatives and metabolites can modify intracellular production of reactive oxygen species (ROS), in particular superoxide and H 2 O 2 .…”

“…Many authors have reported that astaxanthin has a greater affinity with hydrogen peroxide when compared to superoxide [27][28][29]. Recently, Macedo et al [30] showed that astaxanthin significantly reduced the production of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6 in lipopolysaccharide-stimulated neutrophils. The authors also showed that astaxanthin improved neutrophil phagocytic and microbicidal capacity and reduced superoxide anion and hydrogen peroxide production, which appeared to be mediated by calcium released from intracellular storages and nitric oxide production.…”

“…ASTA may act as a strong antioxidant by donating the electrons and reacting with free radicals to convert them into a more stable product and terminate free radical chain reaction in a wide variety of living organisms [25,26]. In recent years, a major number of studies on ASTA have demonstrated its antioxidant effect, for example the quenching effect on singlet oxygen, a strong scavenging effect on superoxide, hydrogen peroxide, and hydroxyl radicals and an inhibitory effect on lipid peroxidation [27][28][29][30]. In addition, several other biologic activities of ASTA, including anti-cancer, anti-inflammatory, antidiabetic, immunomodulatory activities and a neuroprotective effect also have been reported [25,31].…”

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

“…It was suggested that astaxanthin was potentially nutritional therapeutic agent for prevention/prophylaxy of immune-impaired diseases, such as type 2 diabetes, sepsis, and cardiovascular disorders [35]. Macedo et al [36] showed that astaxanthin significantly reduced the production of pro-inflammatory cytokines, such as tumor necrosis factor-a and interleukin-6 in lipopolysaccharidestimulated neutrophils. The results also showed that astaxanthin improved neutrophil phagocytic and microbicidal capacity and reduced superoxide anion and hydrogen peroxide production, which appeared to be mediated by calcium released from intracellular storages and nitric oxide production, indicating a beneficial effect of astaxanthin on human neutrophils function [36].…”

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“…Astaxanthin was found to reduce induced swelling of rat paw, that vitamin E did not reduce 28 . Macedo et al 66 showed that astaxanthin significantly reduced the production of pro-inflammatory cytokines, such as tumor necrosis factor-a and interleukin-6 in lipopolysaccharide stimulated neutrophils.…”