Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis

Rao, Shitao; Han, Xinyu; Shi, Mai; Siu, Cynthia; Waye, Mary Miu Yee; Liu, Guangming; Wing, Yun Kwok

doi:10.1016/j.pnpbp.2018.08.035

Cited by 24 publications

(17 citation statements)

References 121 publications

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“…Other studies also reported association of S allele or S/S genotype with antisocial alcoholism 78 , concussion history and personality traits in rugby players 79 , suicidal ideation in acute coronary syndrome patients 80 , higher impulsivity, hostility and neuroticism in anxiety phenotype 81 , hyperactivity-impulsivity in children moderated by peer problems earlier in childhood 82 and increased exposure to life stressors moderated by ADHD symptoms early in life 83 . Some meta-analyses also describe association of low expression allele/genotype of 5-HTTLPR polymorphism with anti-social behavior 84 , violent suicide attempts 85 and bipolar disorder 86 .…”

Section: Discussionmentioning

confidence: 99%

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Qadeer

Amar

Huang

et al. 2021

Sci Rep

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The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and LA/LA variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and LA/LA genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/LG, LG/LG) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship.

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Section: Discussionmentioning

confidence: 99%

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Qadeer

Amar

Huang

et al. 2021

Sci Rep

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“…The L allele of the 5-HTTLPR was reported as improving transcription of the SLC6A4 gene 84. A meta-analysis noted an association between the S allele of 5-HTTLPR and the risk of bipolar disorder 85. Psychiatric disorders share genetic variants 21.…”

Section: Discussionmentioning

confidence: 99%

Association between the <em>SLC6A4</em> gene and schizophrenia: an updated meta-analysis

Xu¹,

Wang²,

Yao³

2018

NDT

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Background: In order to explore the association between the SLC6A4 gene and the risk of schizophrenia, an updated meta-analysis was conducted using a total of 46 scientific articles. Methods: Through a literature search, papers studied included 35 articles on serotonin-transporter-linked polymorphic region (5-HTTLPR) with 8,752 cases and 10,610 controls, 17 articles on second intron variable number of tandem repeats with 7,284 cases and 8,544 controls, four studies on rs1042173 with 1,351 cases and 2,101 controls, and four studies on rs140700 with 1,770 cases and 2,386 controls. Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots. Results: An association between 5-HTTLPR and the risk of schizophrenia was not found, except for an Indian subgroup analysis (P z =0.014, OR =1.749, 95% CI =1.120-2.731). A 10 repeats/12 repeats (10R/12R) genotype was a protective factor against schizophrenia (P z =0.020, OR =0.789, 95% CI =0.646-0.963), but a 12R/12R genotype was a risk factor for schizophrenia (P z =0.004, OR =1.936, 95% CI =1.238-3.029) in the pooled analyses. In Caucasians, a GG genotype of rs1042173 may be a risk factor for schizophrenia (P z =0.006, OR =1.299, 95% CI =1.079-1.565). No association was found between rs140700 and the risk for schizophrenia. Conclusion: Through meta-analysis, we were able to gain insight into previously reported associations between SLC6A4 polymorphism and schizophrenia.

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“…[22] As low or moderate heterogeneity suggests little variability among these studies, the data will be analyzed in a fixed-effects model. [23] When significant heterogeneity occurs among the studies ( P < .05, I 2 > 50%), a random-effect model will be performed to analyze the data, [24] as well as meta-regression will be adopted to investigate the potential sources of heterogeneity.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture for fecal incontinence

Lin¹,

Zhang

et al. 2019

Medicine

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Background: Fecal incontinence is a socially and emotionally destructive condition that has a negative impact on personal image, self-confidence, and quality of life. Acupuncture is commonly used to treat chronic conditions, including fecal incontinence. However, no relevant systematic review or meta-analysis has been designed to evaluate the effects of acupuncture on fecal incontinence. Methods: We will identify relevant randomized controlled trials (RCTs) from the Cochrane Library, Medline, Embase, PubMed, Springer, Web of Science, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, Wanfang database, and clinical trial registration center from their inception to February 28, 2019. The primary outcome measures will be clinical effective rate, functional outcomes, and quality of life. Data that meets the inclusion criteria will be extracted and analyzed using RevMan V.5.3 software. Two reviewers will evaluate the studies using the Cochrane Collaboration risk of bias tool. Publication bias will be assessed by funnel plots, Egger test, and Begg test using the Stata software. Acupoints characteristics will be analyzed by Traditional Chinese Medicine inheritance support system. Results: This study will analyze the clinical effective rate, functional outcomes, quality of life, daily average number of fecal incontinence, and effective prescriptions of acupuncture for patients with fecal incontinence. Conclusion: Our findings will provide evidence for the effectiveness and potential treatment prescriptions of acupuncture for patients with fecal incontinence. PROSPERO registration number: PROSPERO CRD42019119680.

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Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis

Cited by 24 publications

References 121 publications

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Association between the <em>SLC6A4</em> gene and schizophrenia: an updated meta-analysis

Acupuncture for fecal incontinence

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