Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity

Suzuki, Akihito; Shirata, Toshinori; Noto, Keisuke; Matsumoto, Yoshihiko; Muraosa, Haruka; Abe, Mio; Goto, Kaoru; Otani, Koichi

doi:10.1002/brb3.2674

Cited by 5 publications

(4 citation statements)

References 54 publications

(72 reference statements)

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“…The dispositional interpersonal sensitivity scores were higher in the A/A group than in the A/G ( p = 0.023) and G/G ( p = 0.009) group. 59 The results of this study seem contradictory to the author's view. Thus, because individuals with the A118G allele are hypersensitive to pain, 49 , 50 such individuals are more likely to show the social pain of rejection, given the homology between physical and psychological pain.…”

Section: Opioid Involvement In Rejection Sensitivitycontrasting

confidence: 99%

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Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression

Kaiya

2023

Neuropsychopharm Rep

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This paper aimed to find clues to treatment‐resistant depression (TRD) solutions. Depression comorbid with anxiety is often treatment‐resistant where anxious‐depressive attack (ADA) often lurks. ADA is a recently proposed clinical idea for just a psychological version of a panic attack. It mostly begins with an abrupt surge of intense anxiety followed by uninterrupted intrusive thoughts; lasting ruminations about regret or worry produced by violent anxiety, agitation, and loneliness. Acting‐out behaviors such as deliberate self‐injury and over‐dose may also be observed during the attack. As the basic psychopathology of ADA, rejection sensitivity (RS) was revealed by a structural equation model. It is said that the presence of RS in depressive disorders implies a poor prognosis. The following biological markers for RS were reviewed in the literature: first, the involvement of the μ‐opioid receptor function in RS and, secondly, hypersensitivity of the dopamine D4 receptor (DRD4) in the medial prefrontal cortex. The latter has been suggested in fear‐conditioned animal experiments. Manipulation of the μ‐opioid receptor function together with the DRD4 function may culminate in a treatment for RS, which could contribute to the development of a treatment for TRD via the improvement of ADA.

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Section: Opioid Involvement In Rejection Sensitivitycontrasting

confidence: 99%

“…A study has submitted diametrically opposed results. The dispositional interpersonal sensitivity scores were higher in the A/A group than in the A/G ( p = 0.023) and G/G ( p = 0.009) group 59 . The results of this study seem contradictory to the author's view.…”

Section: Opioid Involvement In Rejection Sensitivitycontrasting

confidence: 96%

Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression

Kaiya

2023

Neuropsychopharm Rep

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“…OPRM1 A118G mutation is the most common and reported functional gene. Some studies have shown that its gene mutation reduces the efficacy of various opioids, and patients with GG need more opioids to relieve pain [ 10 – 13 ].On the other hand, some studies have shown that OPRM1 A118G mutation can enhance the analgesic effect of patients [ 14 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

Is OPRM1 genotype a valuable predictor of VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl?

et al. 2023

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Objective This study was conducted to examine the association between the A118G polymorphism of the OPRM1 gene and the risk of increased VAS scores in patients with colorectal cancer who underwent laparoscopic radical resection for which fentanyl was used. Methods The OPRM1 A118G genotype in subjects were detected. The relationship between the A118G polymorphism of the OPRM1 gene and increased Visual Analogue Scale (VAS) scores throughout the perioperative period was explored. A total of 101 patients receiving fentanyl anesthesia undergoing laparoscopic radical resection of colon tumors at Zhongshan Hospital, Fudan University between July 2018 and December 2020 were investigated in the present study. The relative risk between the A118G polymorphism of the OPRM1 gene and VAS ≥ 4 in the PACU was estimated using the adjusted effect relationship diagram, baseline characteristic analysis, and multiple logistic regression analysis. The relationship between the A118G polymorphism of the OPRM1 gene and VAS in the PACU, as well as perioperative fentanyl usage, was examined after confounders were adjusted. Results Subjects with OPRM1 A118G wild gene A were less sensitive to fentanyl, which was a risk factor for PACU VAS ≥ 4. Before the model was adjusted, the odds ratio (OR) was 14.73 (P = 0.001). After adjusting for age, sex, weight, height, and the duration of surgery, the OR increased to 16.55 (P = 0.001). When adjusting for age, sex, weight, height, surgery duration, COMT Val158Met gene polymorphism, CYP3A4 *1G gene polymorphism, and CYP3A5 *3gene polymorphism, the OR was 19.94 (P = 0.002). Moreover, OPRM1 A118G wild type gene A was found to be a risk factor for increased dosage of fentanyl in the PACU. Before the model was adjusted, the OR reached 16.90 (P = 0.0132). After adjusting for age, sex, body weight, intraoperative fentanyl dosage, surgery duration, and height, the OR was 13.81, (P = 0.0438). When adjusting for age, sex, weight, height, intraoperative fentanyl dosage, surgery duration, COMT Val158Met gene polymorphism, CYP3A4 *1G gene polymorphism, and CYP3A5 *3 gene polymorphism, the OR reached 15.23, (P = 0.0205). Conclusion The A118G polymorphism of the OPRM1 gene carrying wild gene A was a risk factor for VAS ≥ 4 in the PACU. Moreover, it is a risk factor for increased dosage of fentanyl in the PACU.

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“…OPRM1 A118G mutation is the most common and reported functional gene. Studies have shown that its gene mutation reduces the efficacy of various opioids, and patients with GG need more opioids to relieve pain [ [14] , [15] , [16] , [17] ]. Other studies have shown that OPRM1 A118G mutation can enhance the analgesic effect of patients [ [18] , [19] , [20] , [21] ].…”

Section: Discussionmentioning

confidence: 99%

Development of a nomogram for the early prediction of PACU VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl

Zhou

Huang

Cao

et al. 2023

Heliyon

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Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity

Cited by 5 publications

References 54 publications

Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression

Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression

Is OPRM1 genotype a valuable predictor of VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl?

Development of a nomogram for the early prediction of PACU VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl

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