Associations of oral fluid <scp>MMP</scp>‐8 with periodontitis in Swiss adult subjects

Mauramo, Matti; Ramseier, AM; Mauramo, Elina; Buser, Andreas; Tervahartiala, Taina; Sorsa, Timo; Waltimo, Tuomas

doi:10.1111/odi.12769

Cited by 42 publications

(51 citation statements)

References 46 publications

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“…Basel, Switzerland. 22 The final study groups were formed via blinded matching of the HSCT recipients with controls by age and sex. Stimulated saliva flow rate (SSFR) was measured at the beginning of the dental examination and before any clinical assessments.…”

Section: Marrow Donor Registry Of the Blood Transfusion Service Srcmentioning

confidence: 99%

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Uutela

Passweg

Weiger

et al. 2019

European J of Haematology

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Objectives:The purpose of this study was to compare the prevalence of common oral diseases between allogeneic haematopoietic stem cell transplantation (HSCT) recipients and healthy controls. Materials and methods:A total of 143 adult allogeneic HSCT recipients who were treated for haematological malignancies between 2008 and 2016 were included in the study. The HSCT recipients were age and sex matched with healthy controls. A dental examination was performed on the HSCT recipients prior to HSCT. Differences in stimulated saliva flow rate (SSFR), decayed, missing and filled teeth (DMFT) index, number of teeth, number of caries lesions, and measures of current or previous periodontitis (radiological attachment loss >3 mm or probing pocket depth ≥4 mm) between HSCT recipients and controls were examined. Results: Stimulated saliva flow rate, DMFT index and the number of caries lesions were poorer in the HSCT recipients pre-HSCT compared to controls (all P-values <0.05). No statistically significant differences in the measures of current or previous periodontitis were observed.Conclusions: Stimulated saliva flow rate was low and caries was common in HSCT recipients prior to HSCT. Efficient preventive strategies are important in order to maintain the oral health of these patients. K E Y W O R D Scaries, DMFT, haematology, periodontitis, stem cell transplantation

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Section: Marrow Donor Registry Of the Blood Transfusion Service Srcmentioning

confidence: 99%

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Uutela

Passweg

Weiger

et al. 2019

European J of Haematology

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show abstract

“…In periodontology, point-of-care (PoC) tests aim to detect periodontal diseases by analyzing the levels of biomarkers in oral fluids (saliva, oral rinse, and/or gingival crevicular fluid) without need of a laboratory [17,18]. Among the tested biomarkers, salivary and oral rinse levels of MMP-8 are shown to be effective in distinguishing periodontitis patients from periodontally healthy individuals [19][20][21]. For instance, PoC tests using active MMP (aMMP)-8 as a diagnostic marker with a threshold of 20 ng/mL can successfully identify periodontitis with 64-95% sensitivity and 60-100% specificity [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn’s Disease

et al. 2020

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The diagnostic accuracy of point-of-care (PoC) applications may be compromised in individuals with additional inflammatory conditions. This cross-sectional study examined the performance of a commercial oral rinse active matrix metalloproteinase-8 (aMMP-8) PoC immunotest in individuals with (n = 47) and without Crohn’s disease (CD) (n = 41). Oral rinse collected from the participants was analyzed by the PoC immunotest. Molecular forms and fragments of salivary MMP-8 were detected by western immunoblotting. The sensitivity of the immunotest for periodontitis was 60.0% in the CD group and 90.0% in the control group. The respective specificity was 75.0% and 80.0%. In both groups, clinical diagnosis of periodontitis exhibited a significant association with the immunotest results, however, the odds ratio (OR) was more than ten-fold in controls (OR 54.3, 95% CI: 3.1–953, p = 0.006) in comparison to CD patients (OR 5.2, 95% CI: 1.3–21.6, p = 0.022). According to Western immunoblot results, the immunotest MMP-8 positivity was not related to elevated levels of molecular forms and fragments of MMP-8 in the CD group, as in the control group. The diagnostic accuracy of the aMMP-8 PoC oral rinse immunotest is reduced in CD patients, which may be related to lower levels or undetectable complexes.

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“…Similar to that determined in saliva, MMP-8 is increased in patients with periodontitis and provides a good sensitive measure to establish differences between patients and healthy individuals [77]. It is also useful as a complementary tool in the periodontal diagnosis [67]. Another metalloproteinase that has proved useful is MMP-9.…”

Section: Metalloproteinasesmentioning

confidence: 85%

“…Following with the MMP-8, Mauramo et al [67] studied whether the levels of MMP-8 in the saliva are associated with periodontitis in 258 subjects. Periodontitis was more frequent among subjects with high levels of MMP-8 in the saliva.…”

Section: Metalloproteinasesmentioning

confidence: 99%

Use of Biomarkers for the Diagnosis of Periodontitis

González-Ramírez¹,

Serafín-Higuera²,

Mancilla³

et al. 2020

Periodontal Disease - Diagnostic and Adjunctive Non-Surgical Considerations

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Periodontal disease is the most common oral condition of human population; if periodontitis is not treated in its initial stages, it can cause the loss of teeth. The diagnosis of periodontitis is based on clinical measurements. However, currently with the advancement of technology, other diagnostic and monitoring options are being search. In fact, different types of biomarkers have been evaluated where different biological fluids have been used as a source of the sample. We will try to summarize existing biomarkers of different periodontitis stages and make a comparison of the periodontal biomarkers evaluated so far and their usefulness in diagnosis and monitoring of periodontitis.

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Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects

Abstract: Elevated MMP-8 levels both in saliva and GCF are associated with periodontitis in a normal adult population.

Cited by 42 publications

References 46 publications

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn’s Disease

Use of Biomarkers for the Diagnosis of Periodontitis

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