Associations of IL-17A -197G/A and IL-17F 7488T/C polymorphisms with cancer risk in asians: An updated meta-analysis from 43 studies

Hu, Yongtao; Xu, Deping; Xia, Haoran; Zhang, Meng; Liang, Chaozhao

doi:10.1016/j.gene.2021.145901

Cited by 5 publications

(5 citation statements)

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“…Over-activation of the immune system could also be another reason for the increased incidence of solid tumours in HS patients. In support of this hypothesis, meta-analyses have shown a significant increase in cancer risk for elevated IL-17 levels, as well as for colorectal and oral cancers [ 132 ]. An association with hepatocellular carcinoma (HCC) has been shown for common IL-23 polymorphisms [ 133 ].…”

Section: Discussionmentioning

confidence: 99%

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Abu Rached,

Rüth,

Gambichler

et al. 2024

Annals of Medicine

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Purpose Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased risk of malignancy. The aim of this systematic review was to investigate the prevalence of different malignancies in HS. Methods This review meets the PRISMA criteria. A data-driven approach was used to conduct the research, which involved a detailed keyword search. The study considered meta-analyses, experimental studies, case-control studies, cross-sectional studies, cohort studies, and recently published cases, published in English or German. Excluded were reviews, summaries, and letters to the editor, as well as studies, which are not based on the human population. Results Out of the initial 443 publications found, 25 met the inclusion criteria for this systematic review. Patients with HS have a significantly increased risk of cancer, up to 50%. Additionally, the risk of oropharyngeal, central nervous system, colorectal, prostate, vulvar and non-melanocytic skin cancers increase with the severity of HS. The likelihood of comorbid lymphoma in patients with HS is significantly higher compared to healthy controls. In severe cases of HS, malignant degeneration of lesions in the groin, perianal, perineal, and gluteal region can occur in up to 4.6% of cases. This leads to the development of cSCC, which often have a complicated course, are more refractory to treatment and associated with a poorer outcome. The pathogenic mechanisms responsible for the malignant transformation of HS are currently unknown. Conclusions Patients with HS have a higher risk of cancer compared to the general population. Untreated, long-standing HS lesions can lead to complicated malignant degeneration resulting in cutaneous squamous cell carcinoma. The mechanisms underlying this malignant degeneration are not fully understood. HS patients also have an increased risk of developing other cancers, including prostate, oral, pharyngeal and colorectal cancers of the central nervous system and lymphomas.

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Section: Discussionmentioning

confidence: 99%

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Abu Rached,

Rüth,

Gambichler

et al. 2024

Annals of Medicine

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“…The IL-17A gene (Gene ID: 3605) is located at chromosome 6p12.2, and the encoded protein is a proinflammatory cytokine produced by activated T cells, which might involve in the development of human diseases ( 31 ). In the previous paper, it was pointed out that IL-17A rs2275913 acted as risk factor for multiple cancers (gastric, cervical, colorectal and oral carcinoma) ( 15 ) and non-cancerous diseases (RA) ( 33 ). Consistent with our meta-analysis, strong evidence was assigned to IL-17A rs2275913 in lung cancer, cervical cancer, RA, SpA, and IL-17A rs8193037 in lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…These cytokines might have similar synergistic effects on risk of human diseases ( 44 ). In the previous paper, it was pointed out that IL-17F rs763780 might trigger the development of cervical and oral carcinoma ( 15 ) and non-cancerous diseases (such as asthma) ( 45 ). Consistent with our meta-analysis, strong evidence was assigned to IL-17F rs1889570 in asthma, and IL-17F rs763780 in cervical cancer, MS, SpA.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, in an updated meta-analysis conducted in multiple countries from the Asian ancestry, SNP rs2275913 and SNP rs763780 associated with 31,234 subjects were tested. Then it was discovered that IL-17A rs2275913 acted as risk factors for gastric, cervical, colorectal and oral cancer, and IL-17F rs763780 for cervical and oral cancer ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

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Cumulative evidence for associations between genetic variants in interleukin 17 family gene and risk of human diseases

Yang

et al. 2022

Front. Immunol.

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BackgroundGenetic association studies have elucidated the link of variants in the interleukin 17 (IL-17) family genes with susceptibility to human diseases, yet have obtained controversial outcomes. Therefore, we sought to update comprehensive synopsis of variants in the IL-17 family genes with susceptibility to human diseases.MethodsOur study screened the Pubmed and Web of Science to enroll eligible articles and performed a meta-analysis, then graded the cumulative evidence of significant association using Venice criteria and false-positive report probability test, and finally assessed the function of variants with strong evidence.ResultsSeven variants in IL-17 family genes had significant relationships with susceptibility to 18 human diseases identified by meta-analyses. Strong evidence was assigned to 4 variants (IL-17A rs2275913, IL-17A rs8193037, IL-17F rs1889570, IL-17F rs763780) with susceptibility to 6 human diseases (lung and cervical cancer, spondyloarthritis, asthma, multiple sclerosis, rheumatoid arthritis), moderate to 2 variants with risk of 5 diseases, weak to 5 variants with risk of 10 diseases. Bioinformatics analysis suggested that the variants with strong evidence might fall in putative functional regions. Additionally, positive relationships for 5 variants with risk of 4 diseases (based on two datasets) and 14 variants with risk of 21 diseases (based on one dataset) were considered noteworthy.ConclusionsThis study offers updated and comprehensive clues that variants in the IL-17 family genes are significantly linked with susceptibility to cervical, lung cancer, asthma, multiple sclerosis, rheumatoid arthritis and spondyloarthritis, and elucidates the crucial role of the IL-17 regions in the genetic predisposition to cancer or noncancerous diseases.

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“…IL17A polymorphism has also been reported as a risk factor for lupus nephritis [41]. Moreover, the IL17A gene variant has been linked to an increased risk of colorectal cancer in Asians and Caucasians [86,87], osteoarthritis in Caucasians [88], IgA nephropathy in Chinese Hans [89], polycystic ovarian syndrome in Chinese people [90], diabetic nephropathy in Iranians [91], diverse cancer in Asians [92], preeclampsia in Chinese people [93], and rheumatoid arthritis in Europeans [94]. However, IL17A polymorphism has been reported to show no association with many diseases, such as European and Asian psoriasis [95], Egyptian multiple myeloma [96], and Polish periodontitis [97].…”

Section: Discussionmentioning

confidence: 99%

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Ali

Majid

Ali

et al. 2022

JCM

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Interleukin-17A (IL17A) is a proinflammatory cytokine and is assumed to play an important role in fetal rejection. In order to evaluate the potential role of IL17A polymorphism in the pathogenesis of recurrent miscarriage (RM), serum IL17A levels were estimated by ELISA. Single-nucleotide polymorphism was assessed by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) using gene-specific primers and the EcoNI restriction enzyme. Serum IL17A levels were nonsignificantly (p > 0.5) low in RM patients compared with the control group. IL17A gene amplification by PCR yielded the undigested product of 815 bp, and its digestion with EcoNI enzyme produced 815, 529, 286, and 270 bp fragments for the GG genotype; 529, 286, and 270 bp fragments for the GA genotype; and 529 and 286 bp fragments for the AA genotype. The genotype frequency between the RM and control groups exhibited a significant difference (p = 0.001), whereas no significant difference was observed between allele frequencies in the two groups (p = 0.0954). These data suggest that the IL17A gene polymorphism exhibits no significant effect on IL17A gene expression. However, it significantly decreases and increases RM risk in the homozygous and recessive models, suggesting its potential pregnancy-protecting and -harming roles in the AA and GA + GG genotypes, respectively.

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Associations of IL-17A -197G/A and IL-17F 7488T/C polymorphisms with cancer risk in asians: An updated meta-analysis from 43 studies

Cited by 5 publications

References 53 publications

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

A state-of-the-art systematic review of cancer in hidradenitis suppurativa

Cumulative evidence for associations between genetic variants in interleukin 17 family gene and risk of human diseases

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

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