Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis

Skaaby, Tea; Taylor, Amy E; Jacobsen, Rikke Kart; Møllehave, Line Tang; Friedrich, Nele; Thuesen, Betina Heinsbæk; Shabanzadeh, Daniel Mønsted; Paternoster, Lavinia; Völker, Uwe; Nauck, Matthias; Völzke, Henry; Munafò, Marcus R.; Hansen, Torben; Pedersen, Oluf; Jørgensen, Torben; Grarup, Niels; Linneberg, Allan

doi:10.1038/s41430-017-0037-2

Cited by 13 publications

(12 citation statements)

References 38 publications

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“…Our study also found a positive association between dietary vitamin B12 and childhood asthma, which is inconsistent with the findings of current epidemiological studies (25,26). However, it is theorized that vitamin B12 may influence asthma risk by affecting DNA methylation.…”

Section: Discussioncontrasting

confidence: 99%

Dietary Intake and Asthma in Preschoolers: A Logistic Lasso Regression Analysis

Pan

Guo

et al. 2022

Front. Pediatr.

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BackgroundAsthma is a common chronic disease among children, especially preschoolers. Some evidence suggests that diet may play a role in asthma, but the current findings are contradictory. The objective of our study was to determine the association between dietary intake and asthma in preschool children aged 2–5 years.MethodsWe selected preschool children aged 2–5 years with complete data on asthma diagnosis, diet, and body mass index (BMI) from the national health and nutrition examination survey (NHANES) database. In a selected population, children with self-reported asthma were included in the final sample. In children without self-reported asthma, we further used propensity score matching (PSM) to match age and sex for sampling, maintaining a ratio of 1:4 for cases. Lasso regression was used to identify dietary factors affecting asthma in preschoolers.ResultsA total of 269 children with self-reported asthma and 1,076 children without self-reported asthma were included in our study. Univariate analysis showed that there were significant differences in ethnicity and dietary zinc intake between asthmatic children and children without asthma. After adjusting for all dietary and demographic variables, the results of logistic Lasso regression analysis showed that non-Hispanic black (β = 0.65), vitamin B12 (β = 0.14), and sodium (β = 0.05) were positively associated with childhood asthma, while Vitamin K (β = −0.04) was negatively associated with childhood asthma.ConclusionIn conclusion, our study confirms that non-Hispanic black and dietary sodium intake are associated with a higher risk of asthma in preschoolers. In addition, our study found that dietary vitamin B12 was positively associated with childhood asthma, while vitamin K was negatively associated with childhood asthma.

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Section: Discussioncontrasting

confidence: 99%

Dietary Intake and Asthma in Preschoolers: A Logistic Lasso Regression Analysis

Pan

Guo

et al. 2022

Front. Pediatr.

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“…Most asthma definitions were based on self‐reported physician diagnosed asthma, some included wheezing and/or asthma treatment, others relied on hospital contact. Classification of atopic and non‐atopic asthma was based on different methods including fractional exhaled nitric oxide measurements, 17 having allergic rhinitis in combination with use of allergy medication or reported allergic symptoms, 18 positive skin prick test, 13 or investigated allergic sensitization defined as specific IgE positivity to one or more inhalant allergens 19 (Supplementary Results S1).…”

Section: Resultsmentioning

confidence: 99%

“…Skaaby et al. (quality score 10) investigated the association of serum levels of B12 and folate with asthma and hay fever risk, but found no evidence for causation 19 . Neither did Granell et al.…”

Section: Causal Risk Factors For Asthma and Respiratory Allergymentioning

confidence: 99%

Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta‐analysis

Mikkelsen

Landt

Benn

et al. 2022

Clinical & Translational All

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Background Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The aim of the present study was to identify causal risk factors for asthma through Mendelian Randomization studies. Methods A systematic search of PubMed and EMBASE was conducted, to identify studies investigating risk factors for asthma or respiratory allergies through Mendelian Randomization. When two or more studies investigated the same risk factor a meta‐analysis was conducted. Of 239 studies initially identified, 41 were included. Results A causal association between adiposity and adult asthma risk was found in 10 out of 12 studies with a summary risk ratio of 1.05 per kg/m2 increase in BMI (95% CI: 1.03–1.07). Puberty timing (n = 3), alcohol (n = 2), and linoleic acid (n = 1) had causal effects on asthma risk, while vitamins/minerals (n = 6) showed no consistent effect on asthma. The effect of smoking on adult asthma conflicted between studies. Several of the significant associations of asthma with immune related proteins (n = 5) and depression (n = 2) investigated through multiple traits analyses could generally benefit from replications in independent datasets. Conclusion This systematic review and meta‐analysis found evidence for causal effects of adiposity, puberty timing, linoleic acid, alcohol, immune related proteins, and depression on risk of asthma.

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“…Serum folate levels are associated with serum IgE, high plasma folate is associated with decreased risk of wheezing, and folic acid supplementation has been linked with an increased risk for lung cancer . Folate can be produced by most Bacteroidetes, Fusobacteria, and Proteobacteria, but rarely from Actinobacteria and Firmicutes .…”

Section: Metabolites Critically Shape the Microbiomementioning

confidence: 99%

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Untersmayr

Bax

Bergmann³

et al. 2019

Allergy

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The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

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Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis

Cited by 13 publications

References 38 publications

Dietary Intake and Asthma in Preschoolers: A Logistic Lasso Regression Analysis

Dietary Intake and Asthma in Preschoolers: A Logistic Lasso Regression Analysis

Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta‐analysis

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

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