2020
DOI: 10.1186/s13048-020-00640-9
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Abstract: Background: There are about 2.4 hundred thousand new cases and 1.5 hundred thousand deaths of ovarian cancer (OC) annually in the world. Chronic inflammation is a risk factor for OC. C-X-C motif chemokine ligand 1 (CXCL1) defects may facilitate inflammation and transactivate EGFR in ovarian cancer, but the precise haplotypes associated with the potential diseases remained largely unknown. In this work, we characterized CXCL1 gene variations to elucidate their possible associations with OC.Methods: We analyzed … Show more

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Cited by 2 publications
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“…CXCL1 may play a significant role in the tumorigenesis and formation of ovarian cancer, as confirmed by studies on CXCL1 gene polymorphisms. A study on the Chinese Han population showed that the rs11547681 variant affects the risk of ovarian cancer [ 127 ].…”
Section: Ovarian Cancermentioning
confidence: 99%
“…CXCL1 may play a significant role in the tumorigenesis and formation of ovarian cancer, as confirmed by studies on CXCL1 gene polymorphisms. A study on the Chinese Han population showed that the rs11547681 variant affects the risk of ovarian cancer [ 127 ].…”
Section: Ovarian Cancermentioning
confidence: 99%