Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Hirata, Takumi; Arai, Yasumichi; Yuasa, Shinsuke; Abe, Yukiko; Takayama, M.; Sasaki, Takashi; Kunitomi, Akira; Inagaki, Hiroki; Endo, Motoyoshi; Morinaga, Jun; Yoshimura, Kimio; Adachi, Tetsuo; Oike, Yuichi; Takebayashi, Toru; Okano, Hideyuki; Hirose, Nobuyoshi

doi:10.1038/s41467-020-17636-0

Cited by 75 publications

(59 citation statements)

References 73 publications

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“…The concentration of blood biomarkers, including EC-SOD, adiponectin, NTproBNP, cystatin C (CstC), TNF-alpha, and interleukin-6 (IL-6) was measured in accordance with previously described protocols 35 . Blood test results for HbA1c, estimated glomerular filtration rate with creatinine correction (eGFRcreat), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and C-reactive protein (CRP) were also obtained in accordance with previously described protocols 35 .…”

Section: Methodsmentioning

confidence: 99%

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

Sasaki

Abe

Takayama

et al. 2021

Sci Rep

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Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among SOD3 genotype, plasma EC-SOD concentration, and comorbidity in Oldest Old, we analyzed genome-wide associations with plasma EC-SOD concentration and associations between EC-SOD concentration and medical history classified by the SOD3 genotype in the Very Old (85–99 years old, n = 505) and Centenarians (over 100 years old, n = 595). The results revealed that SOD3 p.R231G was the most significant variant associated with plasma EC-SOD concentration. Although no significant difference was observed in medical histories between the SOD3 p.R231G variant non-carriers and carriers, higher EC-SOD concentration in plasma of SOD3 p.R231G variant non-carriers was associated with a high odds ratio for chronic kidney disease (OR = 2.70, 95% CI = 1.98–3.72) and low odds ratio for diabetes mellitus (DM) (OR = 0.61, 95% CI = 0.39–0.95). Comparison with 11 plasma biomarkers for age-related disease showed that plasma EC-SOD concentration correlated with adiponectin and estimated glomerular filtration rate with creatinine correction; therefore, we deduced that EC-SOD co-operates with adiponectin and possesses beneficial functions for DM in the Oldest Old.

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Section: Methodsmentioning

confidence: 99%

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

Sasaki

Abe

Takayama

et al. 2021

Sci Rep

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“…Briefly, the questionnaire and health data were obtained from the KAWP baseline survey conducted between March 2017 and December 2018. All participants were invited to hospitals, interviewed, and examined using a study protocol that was designed by the Tokyo Oldest Old Survey on Total Health and Japan Semi-supercentenarian Study, which were previously managed by the Center for Supercentenarian Medical Research, Keio University School of Medicine [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

ALDH2 p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old

Sasaki

Nishimoto

Hirata

et al. 2021

Genes

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This study identified the factors associated with current and quitting alcohol drinking in the Oldest Old to better understand the associated factors and mechanisms underlying drinking behaviors in this age group. Results of a questionnaire for drinking behavior in 1015 Japanese Oldest Old citizens aged 85 to 89 years revealed that 56.0% of men and 24.0% of women were current drinkers. A genome-wide association study revealed that the rs671 G > A variation, which corresponds to the aldehyde dehydrogenase 2 (ALDH2) p.E504K missense variant, was significantly associated with current drinking (odds ratio: 3.8, p = 3.33 × 10−31). Variable selection with 41 factors and multivariate regression logistic analysis for current drinking indicated that the rs671 genotype and sex were the most significant factors in the Oldest Old. Further analysis revealed that the rs671 genotype, alcohol-associated biomarkers, a history of heart or kidney disease, and frailty score are factors associated with quitting drinking in the Oldest Old men, whereas smoking history, walking time, and depression score were factors associated with quitting drinking in the Oldest Old women. These results indicate that the ALDH2 p.E504K variation is a major factor associated with current and quitting drinking in the Japanese Oldest Old.

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“…All participants were invited to visit one of three Kawasaki Municipal Hospitals (Kawasaki, Ida, or Tama) and were interviewed and examined using a study protocol that was harmonized with the Tokyo Oldest Old Survey on Total Health and Japan Semi-supercentenarian Study, both of which are managed by the Center for Supercentenarian Medical Research, Keio University School of Medicine. 7,8 Participants were asked to ll out a pre-mailed questionnaire including education (high school and higher education or not), living situation, marital status, current alcohol use, smoking status, and self-rated health. They were checked for consistency by interviewers at the time of the baseline survey.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Behavioral changes and hygiene practices of older adults in Japan during the first wave of COVID-19 emergency

Arai

Oguma

Abe

et al. 2021

Preprint

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Background: On April 7, 2020, Japan declared a state of emergency due to the first wave of coronavirus disease 2019 (COVID-19) with the associated social distancing likely to have had a great impact on older adults’ lifestyle and health. This study aimed to explore the behavioral changes and personal hygiene practices in relation with background psychosocial and health characteristics of older adults during the COVID-19 emergency. Methods: A cross-sectional telephonic survey was conducted with the participants of the Kawasaki Aging and Wellbeing Project (KAWP), an on-going longitudinal cohort study of older adults aged 85 or older. The interviews were conducted using a structured questionnaire consisting of 11 closed questions regarding behavioral changes and personal hygiene practices during the state of emergency. Sociodemographic and health data were obtained from the KAWP baseline survey conducted 2.2 years before the telephonic survey.Results: Overall, 487 participants from the KAWP responded to the telephonic survey (response rate: 89.2%). 94.5% of the respondents reported no changes in basic lifestyle habits, such as eating, sleeping, smoking, and drinking, whereas 28.1% reported a decrease in physical activity, and 54.6% reported going out less frequently. One-third of the respondents reported a decrease in the number of people to converse with, as well as the amount of time to converse. For personal hygiene practices, 93.8% reported wearing a mask when they went out, and 50.3% reported an increased frequency of handwashing. Multiple logistic regression analysis revealed that engagement in physical activity at baseline (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.23-3.08), smartphone ownership (OR = 2.15, 95% CI = 1.33–3.47), and visual impairment (OR = 1.79; 95% CI = 1.10–2.91) were independently associated with decreased physical activity during the COVID-19 emergency. Female respondents and smartphone ownership were significantly associated with more frequent handwashing.Conclusions: The study revealed that older adults in an urban setting responded to the COVID-19 emergency with behavioral changes. The findings of this study have implications for the design of preventive strategies to maintain the health and wellbeing of at-risk older adults.

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Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Cited by 75 publications

References 73 publications

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians

ALDH2 p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old

Behavioral changes and hygiene practices of older adults in Japan during the first wave of COVID-19 emergency

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