Associations Between Sleep Duration, Daytime Nap Duration, and Osteoporosis Vary by Sex, Menopause, and Sleep Quality

Abstract

Sleep durations of 7-8 h/d, 9-10 h/d, and 10 h/d or longer, as well as longer daytime napping times, tend to present higher risks of having osteoporosis, and this tendency is most obvious in postmenopausal women reporting good-quality sleep.

Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

“…With respect to sleep duration, participants in the control group averaged 6-7 hours of sleep per night and < 6 hours, but osteoporosis patients fell into two ranges, <6 hours or >7 hours. A previous study demonstrated that a long sleep duration may increase the risk for osteoporosis [23]. Our outcomes showed that more individuals in the osteoporosis group slept for longer periods of time (>7 h) compared with those in the control group.…”

Sleep duration and timing in relation to osteoporosis in an elderly Chinese population: a cross-sectional analysis in the Dongfeng–Tongji cohort study

“…Another Chinese study found an association between sleep duration of 9 h or longer per day and a higher risk of osteoporosis in postmenopausal women, but not in men [17]. In addition, a prospective cohort study of 8101 women aged 69 years or older observed that women with self-reported sleep duration of 10 h or longer per day had a significantly higher risk of non-spinal fracture [21].…”

“…However, the conclusions remain inconsistent. Some studies observed a positive association between long sleep duration and the risk of osteoporosis [4,17], while Fu and his colleagues suggested short sleep duration was associated with lower bone mineral density [18]. Small sample sizes, different exposure distributions, and other characteristics of the study populations may potentially explain the inconsistency in these findings.…”

Does Subjective Sleep Affect Bone Mineral Density in Older People with Minimal Health Disorders? The PROOF Cohort

“…In the primary studies done between 2006-2012, criteria to define OS were self-reported; and when assessed by DXA analysis, only two authors 11,30 made assessments of Tscore that allowed distinction between OP and OS. Moreover, the authors considered large populations from middle-aged to older subjects more frequently in women, with definition of sleep duration and sleep quality based on just one question, "how many hours you sleep," without specific assessment by a validated questionnaire.…”