Associations between Magnetic Resonance Imaging Measures and Neuropsychological Impairment in Early and Late Onset Alzheimer's Disease

Abstract

Cortical atrophy, a key feature of AD, is linked to a wide range of cognitive functions, specifically in early onset AD patients. For WMH, there were no interactions with age at onset, but we found specific associations between temporal WMH and memory and frontal WMH and mental speed.

Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer’s Disease

“…However, since many previous studies have investigated clinical and cognitive progression in LOAD, we do not consider this as a major shortcoming. Present findings on medial temporal lobe atrophy in LOAD are in agreement with previous MRI studies [5, 70] and recent updated pathologic evidence [71], which have highlighted the anatomical differences between EOAD and LOAD. Previous and present MRI findings support the view that medial temporal damage is a key structural substrate in LOAD.…”

Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer’s Disease

“…However, since many previous studies have investigated clinical and cognitive progression in LOAD, we do not consider this as a major shortcoming. Present findings on medial temporal lobe atrophy in LOAD are in agreement with previous MRI studies [5, 70] and recent updated pathologic evidence [71], which have highlighted the anatomical differences between EOAD and LOAD. Previous and present MRI findings support the view that medial temporal damage is a key structural substrate in LOAD.…”

Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

“…The higher the immediate memory, the lower the central atrophy. To our knowledge in this, the largest study utilizing 3T MRI and NeuroQuant, our results are in agreement with the literature [ 56 , 58 – 62 ].…”

Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

“…These findings are consistent with previous studies that have identified advanced age, female gender, and lower educational attainment as risk factors for AD [ 27 , 28 ]. Furthermore, WMH volume was significantly larger in the AD group (20.7±18.2 mL) compared to the NC group (6.8±8.1 mL, p<0.001), supporting prior research linking increased WMH volume to AD risk [ 29 , 30 ]. Using automated quantification methods for brain MRI analysis, we confirmed that WMH volume increases with age and is larger in individuals with AD, consistent with previous findings that associated WMH with aging [ 31 ] and higher AD risk [ 3 , 27 , 32 ].…”

Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer’s Disease

“…However, since many previous studies have investigated clinical and cognitive progression in LOAD, we do not consider this as a major shortcoming. Present findings on medial temporal lobe atrophy in LOAD are in agreement with previous MRI studies [5, 70] and recent updated pathologic evidence [71], which have highlighted the anatomical differences between EOAD and LOAD. Previous and present MRI findings support the view that medial temporal damage is a key structural substrate in LOAD.…”

Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

“…The higher the immediate memory, the lower the central atrophy. To our knowledge in this, the largest study utilizing 3T MRI and NeuroQuant, our results are in agreement with the literature [ 56 , 58 – 62 ].…”

Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

“…These findings are consistent with previous studies that have identified advanced age, female gender, and lower educational attainment as risk factors for AD [ 27 , 28 ]. Furthermore, WMH volume was significantly larger in the AD group (20.7±18.2 mL) compared to the NC group (6.8±8.1 mL, p<0.001), supporting prior research linking increased WMH volume to AD risk [ 29 , 30 ]. Using automated quantification methods for brain MRI analysis, we confirmed that WMH volume increases with age and is larger in individuals with AD, consistent with previous findings that associated WMH with aging [ 31 ] and higher AD risk [ 3 , 27 , 32 ].…”

Mapping the Progression of Atrophy in Early- and Late-Onset Alzheimer’s Disease

“…However, since many previous studies have investigated clinical and cognitive progression in LOAD, we do not consider this as a major shortcoming. Present findings on medial temporal lobe atrophy in LOAD are in agreement with previous MRI studies [5, 70] and recent updated pathologic evidence [71], which have highlighted the anatomical differences between EOAD and LOAD. Previous and present MRI findings support the view that medial temporal damage is a key structural substrate in LOAD.…”

Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

“…The higher the immediate memory, the lower the central atrophy. To our knowledge in this, the largest study utilizing 3T MRI and NeuroQuant, our results are in agreement with the literature [ 56 , 58 – 62 ].…”

Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

“…These findings are consistent with previous studies that have identified advanced age, female gender, and lower educational attainment as risk factors for AD [ 27 , 28 ]. Furthermore, WMH volume was significantly larger in the AD group (20.7±18.2 mL) compared to the NC group (6.8±8.1 mL, p<0.001), supporting prior research linking increased WMH volume to AD risk [ 29 , 30 ]. Using automated quantification methods for brain MRI analysis, we confirmed that WMH volume increases with age and is larger in individuals with AD, consistent with previous findings that associated WMH with aging [ 31 ] and higher AD risk [ 3 , 27 , 32 ].…”