Associations between long-term PM2.5 and ozone exposure and mortality in the Canadian Census Health and Environment Cohort (CANCHEC), by spatial synoptic classification zone

Cakmak, Sabit; Hebbern, Chris; Pinault, Lauren; Lavigne, Éric; Vanos, Jennifer; Crouse, Dan L.; Tjepkema, Michael

doi:10.1016/j.envint.2017.11.030

Cited by 111 publications

(78 citation statements)

References 52 publications

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“…Twelve studies ( Crouse et al, 2015a , Lipsett et al, 2011 , Weichenthal et al, 2017 , Turner et al, 2016 , Lipfert et al, 2006 , Lipfert et al, 2006 , Bentayeb et al, 2015 , Cakmak et al, 2018 , Di et al, 2017 , Krewski et al, 2009 , Smith et al, 2009 , Cakmak et al, 2016 ) reported the association between warm season O 3 exposure and all-cause mortality. Seven studies ( Lipsett et al, 2011 , Weichenthal et al, 2017 , Turner et al, 2016 , Lipfert et al, 2006 , Bentayeb et al, 2015 , Cakmak et al, 2018 , Di et al, 2017 ) with most recent cohort results were included for pooled analysis ( Table 3 a). Meta-analysis result showed that a 10 μg/m 3 increase in O 3 exposure was associated with a RR of 1.01 (1.00, 1.02) per 10 μg/m 3 for all-cause mortality although the heterogeneity was high among studies (I 2 = 98%) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: A systematic review and meta-analysis

Huangfu

Atkinson

2020

Environment International

288

155

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Highlights 46 cohort studies assessed long-term concentrations of NO2 and O3 and mortality. Meta-analysis of 24 studies found increased risk of death associated with NO2. Weak associations were observed for peak period O3 and mortality. High levels of heterogeneity were observed. Certainty in NO2 associations with mortality was generally low/moderate.

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Section: Resultsmentioning

confidence: 99%

“…Only two studies reported the warm season O 3 exposure with COPD mortality ( Table 3 c). Turner 2016 ( Turner et al, 2016 ) showed that increased O 3 exposure was associated with higher risk of COPD mortality, while Cakmak 2018 ( Cakmak et al, 2018 ) found no significant association between O 3 exposure and COPD mortality.…”

Section: Resultsmentioning

confidence: 99%

Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: A systematic review and meta-analysis

Huangfu

Atkinson

2020

Environment International

288

155

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“…Indoor and outdoor air pollution has been deemed as a significant contributor for lung cancer, especially for lung adenocarcinoma and female patients; additionally, it might play a role in the observed urban-rural disparity of lung cancer in Taiwan [26]. e exposure-response relationship was demonstrated by several large cohorts where each 10 μg/ m 3 increase in the ambient PM 2.5 concentration was correlated with an increased risk of lung adenocarcinoma (hazard ratio 1.31; 95% CI � 0.87-1.97) in nonsmokers and an additional 15-27% risk of lung cancer mortality in lifelong never-smokers [26][27][28]. Former smokers had an additional risk of lung cancer in association with outdoor particular matter exposure compared with never-smokers [29].…”

Section: Discussionmentioning

confidence: 97%

Epidemiology and Survival Outcomes of Lung Cancer: A Population-Based Study

Lin

Liu

et al. 2019

BioMed Research International

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Purpose. Lung cancer has been the top-ranking cause of cancer deaths in Taiwan for decades. Limited data were available in global cancer surveillance regarding lung cancer epidemiology in Taiwan, and previous reports are outdated. Patients and Methods. This population-based cohort study extracted data of patients with lung cancer from the Taiwan National Health Insurance database and determined the lung cancer incidence and prevalence during 2002–2014. Histological subtypes were retrieved from the Taiwan Cancer Registry database; survival rates were gathered from the National Death Registry. Average annual percentage changes (APCs) of prevalence, incidence, and overall survival were estimated by joinpoint regression analysis. Results. Age-standardized incidence of lung cancer increased from 45.04 per 100,000 person-years in 2002 to 49.86 per 100,000 person-years in 2014, with an average APC of 0.7 (95% CI = 0.3–1.1; 0.2 in males, 2.0 in females). Lung cancer was more prevalent in male patients, but this increase gradually slowed down. Socioeconomic analysis showed that lung cancer has higher prevalence in patients with higher income level and urban residency. Adenocarcinoma was the most abundant histological subtype in Taiwan (adenocarcinoma-to-squamous cell carcinoma ratio = 4.16 in 2014), with a 2.4-fold increase of incident cases during 2002–2014 (from 43.47% to 64.89% of all lung cancer cases). The 5-year survival rate of lung cancer patients in 2010 was 17.34% (12.60% in male, 25.40% in female), with an average APC of 9.3 (6.3 in male, 11.8 in female) during 2002–2010. Conclusion. Average APCs of prevalence and incidence of lung cancer were 3.1 and 0.7, respectively, during 2002–2014 in Taiwan. The number of female patients and number of patients with adenocarcinoma have increased the most, with incident cases doubling in these years. Facing this fatal malignancy, it is imperative to improve risk stratification, encourage early surveillance, and develop effective therapeutics for lung cancer patients in Taiwan.

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“…Long-term exposure has been linked to premature respiratory mortality in adults [ 69 ] and to increased risk of death in susceptible populations with chronic cardiopulmonary diseases and diabetes [ 70 ]. Less evidence is available for an association between ozone and lung cancer, with one Canadian study finding an odds ratio for lung cancer incidence of 1.09 (0.85–1.39) with a 10-U increase in ozone [ 71 ] and another Canadian study found ozone was a non-significant contributor to lung cancer mortality [ 72 ].…”

Section: Methodsmentioning

confidence: 99%

Pollution and respiratory disease: can diet or supplements help? A review

et al. 2018

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Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world’s largest environmental health risk factor. There has been recent publicity about the role for diet and anti-oxidants in mitigating the effects of pollution, and this review assesses the evidence for alterations in diet, including vitamin supplementation in abrogating the effects of pollution on asthma and other chronic respiratory diseases. We found evidence to suggest that carotenoids, vitamin D and vitamin E help protect against pollution damage which can trigger asthma, COPD and lung cancer initiation. Vitamin C, curcumin, choline and omega-3 fatty acids may also play a role. The Mediterranean diet appears to be of benefit in patients with airways disease and there appears to be a beneficial effect in smokers however there is no direct evidence regarding protecting against air pollution. More studies investigating the effects of nutrition on rapidly rising air pollution are urgently required. However it is very difficult to design such studies due to the confounding factors of diet, obesity, co-morbid illness, medication and environmental exposure.

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Associations between long-term PM2.5 and ozone exposure and mortality in the Canadian Census Health and Environment Cohort (CANCHEC), by spatial synoptic classification zone

Cited by 111 publications

References 52 publications

Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: A systematic review and meta-analysis

Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: A systematic review and meta-analysis

Epidemiology and Survival Outcomes of Lung Cancer: A Population-Based Study

Pollution and respiratory disease: can diet or supplements help? A review

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