Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma

Casson, Alan G.; Zheng, Zuoyu; Chiasson, D.; MacDonald, Kimberley; Riddell, D. Christie; Guernsey, Judith Read; Guernsey, Duane L.; McLaughlin, John

doi:10.1016/s0361-090x(03)00033-3

Cited by 58 publications

(51 citation statements)

References 20 publications

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“…Similarly, two studies in Chinese found an association between the CYP2E1 Rsa1 variant allele and decreased risk of ESCC [30,33] . However, two studies conducted in Brazil and Canada failed to reproduce this observation [34,35] . Results in our study indicated that CYP2E1 c1/c1 or c1 allele increased the susceptibility to ESCC risk in Kazakh population (P<0.05; OR, 11.13; 95%CI, 5.84-21.22 or P<0.05; OR, 4.74; 95%CI, 2.89-7.78), and that individuals with combined GSTM1 presence genotype and CYP2E1 wild type showed a dramatically increased (OR 13.34) risk of ESCC, which is higher than that due to the respective genotypes.…”

Section: Discussionmentioning

confidence: 99%

“…The different liability to cancer was called genetic susceptibility to cancer. Genetic susceptibility can affect in every step of carcinogenesis, including modifying the effect of environmental carcinogens [9][10][11][12][13] . Cancer susceptible genes include types I and II metabolism enzyme genes, DNA repair gene and those affecting cell proliferation rate.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

Lü

Zhang²,

Lin³

et al. 2005

WJG

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AIM: To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China. METHODS:The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls. RESULTS:The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

Lü

Zhang²,

Lin³

et al. 2005

WJG

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“…Previous gastric cancer studies generally found no association with GSTP1 variants, whereas about one-half reported associations with GSTM1 [5], and one reported an inverse age-dependent association with GSTT1 [14]. Associations of esophageal cancer with GSTM1, GSTP1, and GSTT1 were also equivocal [15][16][17][18][19][20][21]. The NAT1*10 variant has been associated with elevated and decreased risks of gastric adenocarcinoma [22], whereas its etiologic role in esophageal cancer remains unexplored.…”

Section: Discussionmentioning

confidence: 99%

GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas

Wideroff

Vaughan

Farin

et al. 2007

Cancer Detection and Prevention

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Condensed Abstract-In a population-based case-control study in the U.S., we examined risks of histologically confirmed esophageal and gastric adenocarcinomas in relation to polymorphisms of the following genes: GSTP; GSTM1; GSTT1; NAT1; and CYP1A1. For the GSTP1 Val/Val genotype (vs. Ile/Ile), the respective ORs of esophageal, cardia, and other gastric adenocarcinomas were 1.73 (0.75-4.02), 1.46 (0.57-3.73), and 1.22 (0.48-3.09), while no consistent patterns of elevated risk were associated with the null GSTM1 or GSTT1 genotypes, one or two copies of NAT1*10 or *11 alleles, or CYP1A1 Val/Val or Ile/Val genotypes (vs. Ile/Ile). Background-Polymorphisms in glutathione-S-transferase (GST), N-acetyltransferase (NAT) 1, and CYP1A1 genes have been suggested as susceptibility factors for esophageal and gastric adenocarcinomas, but have not been consistently linked to elevated risks. In a population-based case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP; GSTM1; GSTT1; NAT1; and CYP1A1.

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“…The products were classified as Ile/Ile (the predominant homozygote), Ile/Val (heterozygote), and Val/Val (the rare homozygote). GSTM1 polymorphism was analyzed by PCR as previously described (23). Primers of 5V -GAACTCCCTGAAAAGCTAAAGC-3V and 5V -GTTGGGCTCAAATATACGGTGG-3V were used in the PCR amplification.…”

Section: Methodsmentioning

confidence: 99%

“…The GSTM1 present genotype produced a 215-bp product that was not visible for the null genotype. Similarly, GSTT1 genotype was also analyzed with PCR (23). Primers of 5V-TCACCGGATCATGGC-CAGCA-3V and 5V-TTCCTTACTGGTCCTCACATCTC-3V were used.…”

Section: Methodsmentioning

confidence: 99%

Association of GSTP1 Polymorphism and Survival for Esophageal Cancer

Lee¹,

Lee³

et al. 2005

Clinical Cancer Research

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Purpose: Activity of glutathione S-transferase (GST) is associated with detoxification of xenobiotics and the maintenance of cell viability. Genetically variant GSTs produce different enzymatic activities.The clinical significance of this variation is still puzzling.We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients. Experimental Design: From1996 to 2002, 233 patients with pathologically proven esophageal cancer were recruited from the Department of Surgery, National Taiwan University Hospital. GST genotypes, including GSTT1, GSTM1, and GSTP1, were determined by PCR or PCR-RFLP. The influence of the genetic polymorphisms on patient survival was estimated using the method of Kaplan-Meier survival function and Cox proportional hazards models. Results: The mean survival times (months) of the GSTP1 Ile/Ile, Ile/Val, and Val/Val were 11, 10, and 7, respectively (P < 0.05). The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio,1.36; 95% confidence interval,1.01-1.84; P trend = 0.045). In contrast, no association of GSTT1 or GSTM1 genotypes with survival rate was noted. Conclusion:The presence of the GSTP1 variant allele (Val) is associated with a poorer prognosis of esophageal cancer.

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Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma

Cited by 58 publications

References 20 publications

Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas

Association of GSTP1 Polymorphism and Survival for Esophageal Cancer

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