Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

Yoon, Chong Hyun; Park, So Eun; Jin, Yoon; Bae, Soong June; Hwan, Chi; Lee, Da Young; Ahn, Sung Gwe

doi:10.1101/551465

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…The TIL counts were measured as previously described [13,18,19]. TILs were scored according to the standardized methodology proposed by the international TIL Working Group [20].…”

Section: Tissue Microarray Sp142 Pd-l1 Assay and Other Studiesmentioning

confidence: 99%

Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer

Ahn

Kim

Shepherd

et al. 2021

Breast Cancer Res Treat

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Purpose The SP142 PD-L1 assay is a companion diagnostic for atezolizumab in metastatic triple-negative breast cancer (TNBC). We strove to understand the biological, genomic, and clinical characteristics associated with SP142 PD-L1 positivity in TNBC patients. Methods Using 149 TNBC formalin-fixed paraffin-embedded tumor samples, tissue microarray (TMA) and gene expression microarrays were performed in parallel. The VENTANA SP142 assay was used to identify PD-L1 expression from TMA slides. We next generated a gene signature reflective of SP142 status and evaluated signature distribution according to TNBCtype and PAM50 subtypes. A SP142 gene expression signature was identified and was biologically and clinically evaluated on the TNBCs of TCGA, other cohorts, and on other malignancies treated with immune checkpoint inhibitors (ICI). Results Using SP142, 28.9% of samples were PD-L1 protein positive. The SP142 PD-L1-positive TNBC had higher CD8+ T cell percentage, stromal tumor-infiltrating lymphocyte levels, and higher rate of the immunomodulatory TNBCtype compared to PD-L1-negative samples. The recurrence-free survival was prolonged in PD-L1-positive TNBC. The SP142-guided gene expression signature consisted of 94 immune-related genes. The SP142 signature was associated with a higher pathologic complete response rate and better survival in multiple TNBC cohorts. In the TNBC of TCGA, this signature was correlated with lymphocyte-infiltrating signature scores, but not with tumor mutational burden or total neoantigen count. In other malignancies treated with ICIs, the SP142 genomic signature was associated with improved response and survival. Conclusions We provide multi-faceted evidence that SP142 PDL1-positive TNBC have immuno-genomic features characterized as highly lymphocyte-infiltrated and a relatively favorable survival.

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“…The TIL counts were measured as previously described [13,18,19]. TILs were scored according to the standardized methodology proposed by the international TIL Working Group [20].…”

Section: Tissue Microarray Sp142 Pd-l1 Assay and Other Studiesmentioning

confidence: 99%

Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer

Ahn

Kim

Shepherd

et al. 2021

Breast Cancer Res Treat

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“…Tumor-infiltrating lymphocytes (TILs) are a specific histological feature of human cancers, reflecting an individual's immunological tumor response (27). Previous studies have reported that TILs may be associated with peripheral blood cells, such as the TLC and absolute neutrophil count (28,29). In esophageal cancer, the PNI and TIL score have been reported to be associated with clinical outcomes (30).…”

Section: A Operative Factorsmentioning

confidence: 99%

Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma

et al. 2020

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The prognostic nutritional index (PNI) is one of the immune parameters calculated on the basis of the serum albumin and the total lymphocyte count. The aim of the present study was to investigate the prognostic significance of the PNI for short-and long-term outcomes after liver resection for patients with hepatocellular carcinoma (HCC). Data from 162 surgically treated patients with HCC (without any previous treatment) were retrospectively analyzed. The cutoff value of preoperative PNI was 45.0, which was calculated by a receiver operating characteristic curve for predicting the recurrence of HCC after liver resection. Patients were divided into low (n=86) and high (n=76) PNI groups. In short-term outcomes, patients in the low PNI group were more likely to experience postoperative complications compared with those in the high PNI group. The 5-year disease-free survival (DFS) rate in the low PNI group was significantly lower compared with that in the high PNI group (20.5% vs. 48.7%). In the multivariate analysis, a low PNI was an independent prognostic factor for DFS (HR, 1.65; 95% CI, 1.00-2.71). In conclusion, the preoperative PNI may be a prognostic factor for evaluating short-and long-term outcomes after liver resection in patients with HCC.

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“…TILs have attracted recent attention with the development of immune checkpoint inhibitors. In addition, there were some reports TILs had the relationship between peripheral blood cells, such as TLC and absolute neutrophil count (ANC) [23,24].…”

Section: Resultsmentioning

confidence: 99%

“…Lymphocyte-predominant breast cancer (LPBC), which has high TIL levels, has a good prognosis [22]. Lee et al reported a signi cant correlation between peripheral lymphocyte count and TILs in patients with cervical carcinoma [23], whereas Yoon et al reported a signi cant relationship between TILs and peripheral neutrophil count in breast cancer [24].…”

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confidence: 99%

Prognostic Implications of Lymphocyte/C-Reactive Protein Ratio With Tumor-Infiltrating Lymphocytes in Resected Intrahepatic Cholangiocarcinoma

Miyazaki

Morine

Imura

et al. 2020

Preprint

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BackgroundLymphocyte/C-reactive protein (CRP) ratio (LCR), is a promising prognostic factor that can reflect tumor inflammation and systemic patient condition. The aim of this study was to investigate whether preoperative LCR can be a prognostic factor for post-surgical outcomes among patients with intrahepatic cholangiocarcinoma (IHCC). We also investigated the relationship between LCR and tumor infiltrating lymphocytes (TILs) to clarify whether systemic host immune parameters reflect local tumor immunity.MethodsWe enrolled 45 patients who had undergone hepatectomy for IHCC. Patients were divided into low LCR and high LCR groups, according to reactive operating characteristic curve (Cut-off value: 8836). We analyzed their overall survival (OS) and disease-free survival (DFS) with respect to LCR and other clinicopathological factors. We also investigated stromal TILs and numbers of CD8+ TILs in surgical specimens, and the relationship between LCR and TILs.ResultsTwenty-one patients (46.7%) were associated with low LCR. Low LCR was significantly correlated with older age, high CRP and advanced disease stage, and was a prognostic factor for OS and DFS. And multivariate analysis revealed that low LCR was an independent prognostic factor for worse OS (HR: 2.81 P<0.04). Regarding the relationship between LCR and local tumor immunity, while LCR and levels for stromal TILs were significantly related, LCR and levels for CD8+ TILs were significantly related. ConclusionsPreoperative LCR levels could predict the post-surgical prognosis of patients with IHCC, and reflected numbers of intra-tumoral CD8+ TILs.Trial registrationThis study was approved by Tokushima University Hospital ethics committee and with the approval of corresponding regulatory agencies, and all the experiments were carried out in accordance with the approved guidelines (Tokushima Clinical Trial Management System Number; 3215). All the patients involved in this study signed informed consent forms and agreed to participate.

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Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

Cited by 3 publications

References 36 publications

Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer

Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer

Preoperative prognostic nutritional index predicts short‑ and long‑term outcomes after liver resection in patients with hepatocellular carcinoma

Prognostic Implications of Lymphocyte/C-Reactive Protein Ratio With Tumor-Infiltrating Lymphocytes in Resected Intrahepatic Cholangiocarcinoma

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