2009
DOI: 10.1016/j.neuron.2009.05.008
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Abstract: Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamically regulated by intracellular cAMP; the range of this regulation, however, largely differs among neurons in the mammalian brain. Using affinity purification and high-resolution mass spectrometry,… Show more

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Cited by 115 publications
(154 citation statements)
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References 63 publications
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“…So far, however, experimental procedures enabling unbiased and comprehensive access to the environment of membrane proteins have been missing or have just begun to evolve (17)(18)(19)(20)(21)(22)(23)34).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…So far, however, experimental procedures enabling unbiased and comprehensive access to the environment of membrane proteins have been missing or have just begun to evolve (17)(18)(19)(20)(21)(22)(23)34).…”
Section: Discussionmentioning
confidence: 99%
“…3 and Table 1). This complexity is specific for Cav2 channels, because rather limited sets of partner proteins were obtained under the same conditions for other ion channels (17,22,23). CL-114, a buffer with increased stringency, seemingly interfered with the integrity of protein networks, stripping away the less tightly integrated components.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The auxiliary protein TRIP8b is a key regulator of HCN channels in physiological and pathological conditions (32,35,36). However, the expression of TRIP8b was similar in the dorsal and ventral hippocampus.…”
Section: Table 1 Data Summary Of the Basic Properties Of Ca1 Pyramidamentioning
confidence: 99%
“…While TRIP8b (1b-2) expressed at somewhat lower levels, accounts for 10%-15% of total brain TRIP8b mRNA [51]. TRIP8b (1a-4) strongly increases HCN1 surface expression [51,52] and decreases the surface expression of HCN2 [53]. While TRIP8b (1b-2) has been reported to produce a potent downregulation in the surface expression of HCN1 and HCN2 [43].…”
Section: Reviewmentioning
confidence: 99%