Association Study of MMP-9 −1562C/T Gene Polymorphism with Susceptibility to Multiple Autoimmune Diseases: A Meta-analysis

Li, Jing; Lin, Shuangyan; Lv, Yanbo; Tang, Haimin; Peng, Fang

doi:10.1016/j.arcmed.2017.01.001

Cited by 8 publications

(5 citation statements)

References 45 publications

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“…Genome-wide association studies (GWAS) have shown some genetic risk factors for AIDs, and several genes may suggest common mechanisms that lead to the development and progression of AIDs, including SLE [27, 28]. In the past many studies have focused on RNAs, and aberrant expression of mRNA levels has been observed in SLE patients, such as IL-28RA , DNMT1 and DNMT3A [29, 30].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus

Zhang

Liang

Yuan

et al. 2019

aoms

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Introduction A great deal of research has reported dysregulated expression of genes in systemic lupus erythematosus (SLE). This study aimed to analyze the lncRNA, miRNA and mRNA expression profile in SLE. Material and methods RNA sequencing (RNA-seq) was used to detect the dysregulated RNAs in SLE. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis were used to explore the function of these differentially expressed RNAs. Results 2,353 lncRNAs, 827 mRNAs and 24 miRNAs were shown to be differentially expressed. GO analyses demonstrated that differentially expressed RNAs were enriched in a variety of molecular functions and biological processes including ribonucleotide, protein serine/threonine kinase activity function, regulation of B cell differentiation and others. KEGG pathway analyses revealed that differentially expressed mRNAs and lncRNAs were both enriched in FcγR-mediated phagocytosis, glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulfate and glyoxylate and dicarboxylate metabolism pathways. The up-regulated miRNAs target genes were mainly enriched in the nuclear factor-κB (NF-κB) signaling pathway. The down-regulated miRNAs target genes were significantly enriched in metabolism of xenobiotics by cytochrome P450, bile secretion and terpenoid backbone biosynthesis pathways. Conclusions The current study reveals a comprehensive expression profile of lncRNAs, miRNAs and mRNAs and implies potential regulatory functions of these RNAs which are involved in the pathogenesis of SLE.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus

Zhang

Liang

Yuan

et al. 2019

aoms

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“…Previously, large genome-wide association study (GWAS) did not reveal that MMP9 polymorphisms to be significantly associated with the risk for MS [49]. Additionally, a meta-analysis performed on the case-control studies from Europe and one Brazilian study and did not indicate a significant association of MMP9 (− 1562 C/T) SNP with and MS susceptibility [50]. The number of included studies in the meta-analysis was limited and inclusion of further recent studies in Asian populations, like Iran and Egypt, led to significant association of MPP9 polymorphism with MS susceptibility.…”

Section: Discussionmentioning

confidence: 98%

Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis

et al. 2020

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Background: Several studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). However, the results have been inconsistent and inconclusive. To resolve this issue, here we performed a systematic review and meta-analysis of the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. Methods: We conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies published before December 2019 that surveyed the association between the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. The level of association between the polymorphisms and susceptibility to MS in the polled analysis was determined by calculating the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results: We found 15 studies containing 2430 MS subjects and 2304 controls. A statistically significant association was observed in the all five comparisons of the MMP-91562 C/T polymorphism and MS risk as follows: dominant model (

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“…Contrary to our findings, some studies exhibited a decreased T allele frequency in MS patients in Serbian population (26–28). In addition, results of a recent meta-analysis manifested a significant association between MMP-9 1562 C/T polymorphism with other autoimmune diseases but it revealed no significant association between MMP-9 1562 C/T polymorphism and MS patients (29). Another polymorphism is the microsatellite (CA)n, consists of different repeat number of cytosine-adenine (13–27), which allele frequencies distribution culminates in two groups of CA≤14 and CA≥21–23.…”

Section: Discussionmentioning

confidence: 99%

Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

Sabbagh

Nadeali

Dehghani

et al. 2020

ijph

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Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.

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Association Study of MMP-9 −1562C/T Gene Polymorphism with Susceptibility to Multiple Autoimmune Diseases: A Meta-analysis

Cited by 8 publications

References 45 publications

Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus

Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus

Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis

Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

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