2016
DOI: 10.18632/aging.101097
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Abstract: Mannose binding lectin (MBL) plays important role in the innate immunity of human. Mutations in the MBL2 gene can significantly change the serum level of MBL, and consequently alter the susceptibility and progression of infectious disease. However, the association between the MBL2 profile and the HBV mutation and quasispecies complexity has not yet been reported. Our approach includes the study of the MBL2 gene genotype as well as ultra-deep sequencing of the HBV viruses obtained from the plasma of 50 treatmen… Show more

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Cited by 4 publications
(3 citation statements)
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“…Given the quasispecies nature of HBV, we also evaluated the prevalence of those amino acid substitutions at low level within samples from treatment-naïve patients. In this exploratory study, the HBV genomes from 50 chronically HBV-infected treatment-naïve Chinese patients were subjected to ultra-deep pyrosequencing (UDPS) 29 . Interestingly, we find low-abundance quasispecies (frequency bellow 2.5%) containing substitutions P25S in one patient and V124F in four patients ( Table 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…Given the quasispecies nature of HBV, we also evaluated the prevalence of those amino acid substitutions at low level within samples from treatment-naïve patients. In this exploratory study, the HBV genomes from 50 chronically HBV-infected treatment-naïve Chinese patients were subjected to ultra-deep pyrosequencing (UDPS) 29 . Interestingly, we find low-abundance quasispecies (frequency bellow 2.5%) containing substitutions P25S in one patient and V124F in four patients ( Table 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…study of a Chinese Han population demonstrated that polymorphisms in the interleukin (IL)-10 gene significantly impact the risk of HBV infection, but not the recovery after infection (9). Prior to the present study, we investigated 50 treatment-naïve patients with chronic HBV infection and found that polymorphisms in innate immunity gene mannose-binding lectin 2 impact the HBV mutation frequency as well as liver function parameters, including alanine aminotransferase (ALT) and aspartate transaminase (AST) (10). Nuclear factor (NF)-κB is a protein complex involved in several processes, including cytokine production and cell survival; it is also involved in the cellular response to stimuli such as stress, ultraviolet irradiation, and bacterial or viral antigens (11).…”
Section: Introductionmentioning
confidence: 88%
“…MBL2 gene mutations have been related to the progression of the infection to the chronic phase, with the development of cirrhosis and hepatocellular carcinoma, and to the different responses to therapy [19, 20]. Recently, it was reported that the presence of mutant alleles in the promoter region (−221 C>G) of the MBL2 gene could protect against the more severe forms of the liver injury (cirrhosis and HCC) [21], and a better liver function was shown as associated with high MBL serum levels [22]. Furthermore, Zupin et al [23] reported that MBL2 polymorphisms were not associated with HCV infection susceptibility and with spontaneous viral clearance, while MBL2 ∗ O allele, OO genotype, and HYO haplotype, all correlated with low or deficient MBL expression, were associated with sustained virological response (SVR).…”
Section: Introductionmentioning
confidence: 99%