Chenghao Su, Yong Lin, Qianguo Mao, Daitze Wu, Lina Zhu, Isabel Najera, Fernando Garcia-Alcalde, Jianjun Niu
Abstract:Mannose binding lectin (MBL) plays important role in the innate immunity of human. Mutations in the MBL2 gene can significantly change the serum level of MBL, and consequently alter the susceptibility and progression of infectious disease. However, the association between the MBL2 profile and the HBV mutation and quasispecies complexity has not yet been reported. Our approach includes the study of the MBL2 gene genotype as well as ultra-deep sequencing of the HBV viruses obtained from the plasma of 50 treatmen…
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