2008
DOI: 10.1158/0008-5472.can-07-6686
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Although several epidemiologic studies have shown that ;-glutamyltransferase (GGT) is independently associated with cardiovascular disease and all-cause mortality, its relationship with cancer incidence remains widely unexplored. In several experimental models, the ability of cellular GGT to modulate crucial redox-sensitive functions has been established, and it thus may play a role in tumor progression, as has been repeatedly suggested. We prospectively investigated the association between GGT and risk of ove… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

10
96
2
2

Year Published

2008
2008
2022
2022

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 99 publications
(110 citation statements)
references
References 40 publications
10
96
2
2
Order By: Relevance
“…Although two epidemiologic investigations failed to detect an association between ␥-GT and cancer mortality in middle-aged men, 4,31 a strong significant relationship between ␥-GT and risk of cancer incidence was found in a recent analysis from an Austrian prospective study. 32 The most novel finding of the present study was the strong association of ␥-GT levels with disability pension due to musculoskeletal disorders, which was seen among cases due to osteoarthritis as well as dorsopathy even at levels in the normal range of ␥-GT. Few studies have focused on the association of ␥-GT with musculoskeletal disorders.…”
Section: Discussionsupporting
confidence: 48%
“…Although two epidemiologic investigations failed to detect an association between ␥-GT and cancer mortality in middle-aged men, 4,31 a strong significant relationship between ␥-GT and risk of cancer incidence was found in a recent analysis from an Austrian prospective study. 32 The most novel finding of the present study was the strong association of ␥-GT levels with disability pension due to musculoskeletal disorders, which was seen among cases due to osteoarthritis as well as dorsopathy even at levels in the normal range of ␥-GT. Few studies have focused on the association of ␥-GT with musculoskeletal disorders.…”
Section: Discussionsupporting
confidence: 48%
“…According to the previous study GGT enzyme also had a significant relationship with increased HCC risk and there was also a significant association between GGT and overall cancer incidence (19). This contrasts with our study which showed no significant relationship and this goes with other study which showed no association with cancer mortality (20).It is important to notice that GGT levels could be affected by factors like diet, environmental pollutants and xenobiotic (19).…”
Section: Discussioncontrasting
confidence: 96%
“…This contrasts with our study which showed no significant relationship and this goes with other study which showed no association with cancer mortality (20).It is important to notice that GGT levels could be affected by factors like diet, environmental pollutants and xenobiotic (19). The main cause of Liver cirrhosis in this study was HBV, in agreement with another study which indicated that HBV is of high seroprevalence in Sudan (21).…”
Section: Discussioncontrasting
confidence: 68%
“…Among men, we recently found that elevated GGT levels were significantly associated with increased risk of overall cancer incidence and several site-specific malignancies. 28 In the present analysis, we focus on the association of GGT and cancer incidence in 92,843 women in the same cohort. To our knowledge, this is the first epidemiologic investigation of the association of GGT and cancer incidence in a large population-based cohort of women.…”
mentioning
confidence: 99%