Association of Vitamin K Status Combined With Vitamin D Status and Lower‐Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts

Shea, M. Kyla; Loeser, Richard F.; McAlindon, Timothy E.; Houston, Denise K.; Kritchevsky, Stephen B.; Booth, Sarah L.

doi:10.1002/acr.23451

Cited by 18 publications

(13 citation statements)

References 47 publications

(98 reference statements)

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“…So vitamin D supplementation could be used for knee OA pain. Vitamin D supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients, and improves lower extremity functions ( Manoy et al, 2017 ; Shea et al, 2017 ). However Sanghi et al (2013) assert a reason for the positive effect of vitamin D, which in many studies only OA patients with insufficiency vitamin D, the group most likely benefit from supplementation.…”

Section: Discussionmentioning

confidence: 99%

Association between vitamin D concentrations and knee pain in patients with osteoarthritis

Çakar

Ayanoğlu

Çabuk

et al. 2018

PeerJ

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ObjectivesOsteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain.Subjects and MethodsVitamin D concentrations were measured with the 25 hydroxyvitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient (10 to 19 ng/mL), or normal (20 to 50 ng/mL).ResultsOf 149 patients (133 women), the mean age was 63.6 years. Mean vitamin D concentration was 11.53 ng/mL, and 90% patients were vitamin D deficient. Mean WOMAC score was 57.2, and VAS pain score was 7.5. Kellgren-Lawrence grade was 2 for 10 patients, grade 3 for 61, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status.ConclusionSerum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

Association between vitamin D concentrations and knee pain in patients with osteoarthritis

Çakar

Ayanoğlu

Çabuk

et al. 2018

PeerJ

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“…However, both nutrients were not associated with gait speed. On the other hand, adequate vitamin K (≥ 90 µg/day for women or 120 µg/day for men) and D intake (≥ 600 IU for age < 70 years, ≥ 800 IU for age ≥ 70 years) were associated with overall 20-m gait speed and chair stand completion time, on follow-up, but not in the 400-m walk time [37]. In another study, subjects with vitamin K deficiency also showed higher pain scores on The Western Ontario McMaster Scale Scores, after 12 months follow-up study [25].…”

Section: Prospective Studiesmentioning

confidence: 94%

“…Therefore, long-term supplementation of vitamin K for preventing OA might be safe, but there is a paucity of trial data to support this claim. The effective dose of vitamin K in preventing OA remains elusive, but some data suggest that maintaining the circulating vitamin K concentration around 1.0 nmol/L is associated with better joint health [29,37].…”

Section: Perspectivesmentioning

confidence: 99%

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Chin

2020

Nutrients

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Vitamin K is a cofactor of γ-glutamyl carboxylase, which plays an important role in the activation of γ-carboxyglutamate (gla)-containing proteins that negatively regulate calcification. Thus, vitamin K status might be associated with osteoarthritis (OA), in which cartilage calcification plays a role in the pathogenesis of the disease. This review collates the evidence on the relationship between vitamin K status (circulating or dietary intake level of vitamin K, or circulating uncarboxylated gla proteins) and OA from human observational studies and clinical trial, to examine its potential as an agent in preventing OA. The current literature generally agrees that a sufficient level of vitamin K is associated with a lower risk of OA and pathological joint features. However, evidence from clinical trials is limited. Mechanistic study shows that vitamin K activates matrix gla proteins that inhibit bone morphogenetic protein-mediated cartilage calcification. Gla-rich proteins also inhibit inflammatory cascade in monocytic cell lines, but this function might be independent of vitamin K-carboxylation. Although the current data are insufficient to establish the optimal dose of vitamin K to prevent OA, ensuring sufficient dietary intake seems to protect the elderly from OA.

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“…Supplementation with vitamin K is used to treat and prevent osteoporosis and osteoarthritis in humans (Neogi et al 2006;Oka et al 2009;Misra et al 2013;Shea et al 2017). In Japan MK-4 is frequently used to aid in the prevention and treatment of osteoporosis with high doses of 45mg/day prescribed .…”

Section: Osteocalcin and Bone Metabolism And Diseasementioning

confidence: 99%

“…Vitamin K has been shown to play a vital role in bone development (Shea et al 2017). This role stems from its relationship to the bone protein, osteocalcin (Shea & Booth 2008).…”

Section: Introductionmentioning

confidence: 99%

Vitamin K and equine osteocalcin: an enigma explored

Skinner¹

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Vitamin K has received considerably less attention over the past 50 years compared to other fat soluble vitamins. Intakes of vitamin K beyond that required for normal blood coagulation were believed to confer no additional benefits, and therefore rarely investigated. The requirements and physiological role of vitamin K appeared to be secure. This view of vitamin K has changed recently following the delineation of its cofactor role in protein carboxylation, and the growing awareness of its interactions with other essential metabolic functions, beyond that of blood coagulation; there is much to be discovered. At present, seventeen vitamin Kdependent proteins (VKDPs) have been characterised, but the functionality of some still remains to be elucidated. Vitamin K has recently been implicated in osteoarthritis and accumulating evidence from human studies supports a protective role for vitamin K. To date however, little research into the role vitamin K may play in equine bone development exists. Developmental orthopaedic disease (DOD) is a term that encompasses a number of bone related conditions in the horse. It is a significant cause of lameness and wastage in a number of breeds, in particular Thoroughbreds and Warmbloods. It has clinical features in common with that of osteoporosis and osteoarthritis in the elderly. The VKDP osteocalcin is one of the few that has been extensively studied in humans and rodents. Located within bone, this protein plays a vital role in bone metabolism, facilitating the binding of bone minerals with protein. Decreased functionality of this protein has been found to be associated with increased fracture risk and osteoporosis in humans. The studies in this program were initiated to establish the relationship between vitamin K status and the development of DOD in foals. As bone development begins in utero, the first step was to examine placental transfer of the vitamin and then determine availability to the foal through milk. It was found in the initial experiments (Chapter 3), that foals at birth, had negligible concentrations of vitamin K1 (<0.01ng/mL) in both umbilical cord and foal plasma. The results clearly demonstrated that there is limited trans-placental transfer of vitamin K in the horse. It was also shown that milk can be enriched with vitamin K by supplementation of the mare with the vitamin. These studies confirmed that plasma concentrations were not a reliable measure of overall vitamin K status. Circulating osteocalcin and, its carboxylation status, has been proposed as one of the indicators of vitamin K status and a 'biomarker' of bone metabolism. Current assays available to measure Publications included in this thesis "No publications included". v

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Association of Vitamin K Status Combined With Vitamin D Status and Lower‐Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts

Abstract: Sufficient vitamin K status combined with sufficient vitamin D status was associated with better lower-extremity function in 2 knee OA cohorts. These findings merit confirmation in vitamin K and D co-supplementation trials.

Cited by 18 publications

References 47 publications

Association between vitamin D concentrations and knee pain in patients with osteoarthritis

Association between vitamin D concentrations and knee pain in patients with osteoarthritis

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Vitamin K and equine osteocalcin: an enigma explored

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