Association of Vascular Factors With Apathy in Community-Dwelling Elderly Individuals

Ligthart, Suzanne A.; Richard, Edo; Fransen, Nina L.; Eurelings, Lisa S. M.; Beem, Leo; Eikelenboom, Piet; Gool, Willem A. van; Charante, Eric P. Moll van

doi:10.1001/archgenpsychiatry.2011.1858

Cited by 71 publications

(144 citation statements)

References 31 publications

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“…Logistic analysis was performed to evaluate the association between CFPWV and a dichotomous measure of depressive symptoms. It has been suggested 24 that cerebral small vessel disease may be associated with, in particular, apathy-related or motivation-related symptoms of depression, but not with mood-related symptoms. Therefore, we performed logistic regression analyses to evaluate the association between CFPWV and individual apathy items of the GDS-15 score as the outcome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Sloten

Mitchell

Sigurðsson

et al. 2016

jpn

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Section: Discussionmentioning

confidence: 99%

“…"; and 3) "Do you feel full of energy?". 24,25 As described previously, 24,25 we distinguished an apathy subscale that included all apathy items (range 0-3; GDS-3A). Presence of apathy was defined as a GDS-3A score of 2 or 3 versus no apathy (score of 0 or 1).…”

Section: Depressive Symptomsmentioning

confidence: 99%

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Sloten

Mitchell

Sigurðsson

et al. 2016

jpn

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“…Furthermore, apathy was associated with cognitive and functional impairments in elders adjudged to have normal cognition [48]. It has been reported that up to a quarter of nondemented community-dwelling elderly individuals have apathy (most without concomitant depression) [50,51]. In this population a past history of stroke (OR 1.8; 95% CI 1.4–2.3) [50] or other vascular diseases are risk factors for apathy [51].…”

Section: Discussionmentioning

confidence: 99%

Apathy Secondary to Stroke: A Systematic Review and Meta-Analysis

2013

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Background: Apathy is a disturbance of motivation, frequent in survivors of stroke. Several studies have evaluated the rate of apathy secondary to stroke and risk factors. Different conclusions and contradictory findings have been published. We aimed to perform a systematic review and meta-analysis of all studies evaluating apathy secondary to stroke to better estimate its rate and risk factors, and explore associations with poorer outcomes. Methods: We searched PubMed, Cochrane Library, PsychINFO and PsycBITE databases and screened references of included studies and review articles for additional citations. Search results and data extraction was performed independently. We systematically reviewed available publications reporting investigations on ischemic and intracerebral hemorrhagic stroke and apathy. Quality assessment of the studies was performed independently. Subgroup analyses were performed according to stroke phase (acute and post-acute), stroke past history (first-ever and any-stroke) and patient age (younger and older patients). Pooled odds ratios (OR) and standardized mean difference, and 95% confidence intervals (CI), were derived by random-effects meta-analysis. Heterogeneity was assessed with I² test. Results: From the initial 1,399 publications, we included 19 studies (2,221 patients). The pooled rate of apathy was 36.3% (95% CI 30.3–42.8; I² = 46.8), which was similar for acute [39.5% (95% CI 28.9–51.1)] and post-acute phase [34.3% (95% CI 27.8–41.4)], and about three times higher than the rate of depression [12.1% (95% CI 8.2–17.3)]. Apathetic patients were on average 2.74 years older (95% CI 1.25–4.23; I² = 0%). No gender differences were found. Depression (OR 2.29; 95% CI 1.41–3.72; I² = 44%) and cognitive impairment (OR 2.90; 95% CI 1.09–7.72; I² = 14%) were more frequent and severe in apathetic patients. Apathy rate was similar for ischemic and hemorrhagic stroke type and for left- and right-sided hemispheric lesions. Clinical global outcome was similar between apathetic and nonapathetic patients. Conclusion: Apathy secondary to stroke is a more frequent neuropsychiatric disturbance than depression. Apathetic patients are more frequently and severely depressed and cognitively impaired. A negative impact of apathy secondary to stroke on clinical global outcome cannot be ascribed. Future research should properly address its predictor factors and evaluate the impact of apathy treatment options in stroke patients.

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“…In healthy volunteers of comparable age, apathy was found in 6.0% and 53 In another study, a community-based sample of elderly, a prevalence of 19.9% was found. 54 This suggests that not all cases of poststroke apathy are directly attributable to the stroke, although its prevalence is higher in patients with a history of multiple strokes.…”

Section: Prevalencementioning

confidence: 99%

Poststroke Apathy

Dalen

Charante

Nederkoorn

et al. 2013

Stroke

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Association of Vascular Factors With Apathy in Community-Dwelling Elderly Individuals

Abstract: Symptoms indicative of apathy are common in community-dwelling nondemented older people who are free from depression. The independent association of stroke, other cardiovascular disease, and cardiovascular risk factors with symptoms of apathy suggests a causal role of vascular factors.

Cited by 71 publications

References 31 publications

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Apathy Secondary to Stroke: A Systematic Review and Meta-Analysis

Poststroke Apathy

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