Association of Urinary Phytoestrogen Concentrations with Serum Concentrations of Prostate-Specific Antigen in the National Health and Nutrition Examination Survey

Walser-Domjan, Esther; Richard, Aline; Eichholzer, Monika; Platz, Elizabeth A.; Linseisen, Jakob; Rohrmann, Sabine

doi:10.1080/01635581.2013.801999

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…The DXA equipment used was a Hologic QDR 4500A fan beam densitometer [20]. During 1999–2002, NHANES also collected data on muscle strength as measured by the isokinetic strength of the knee extensors using a Kin Com MP dynamometer [21], which enabled the study of both muscle mass and muscle strength. A total of 2,647 men and women, 50 years of age and older, with muscle mass and muscle strength data available from the NHANES 1999–2002, were included in the present study.…”

Section: Methodsmentioning

confidence: 99%

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Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States

et al. 2013

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BackgroundLoss of muscle mass and muscle strength are natural consequences of the aging process, accompanied by an increased prevalence of chronic health conditions. Research suggests that in the elderly, the presence of comorbidities may impact the muscle mass/strength relationship. The objectives of this study were to characterize the muscle mass/strength relationship in older adults in the USA and to examine the impact of a variety of comorbidities on this relationship.MethodsData were obtained from the National Health and Nutrition Examination Survey 1999–2002 databases. Subjects aged 50 years and older were included in the present study. Muscle mass was assessed by height-adjusted appendicular skeleton muscle mass (aASM) in kg/m2, as measured by dual-energy x-ray absorptiometry. Muscle strength was assessed via isokinetic quadriceps strength (IQS) in newton as measured by a dynamometer. The relationship between aASM and IQS was assessed adjusting for age and gender. The effects of a variety of comorbidities on IQS and/or on the relationship between IQS and aASM were assessed using multiple regression models.ResultsThis study included 2,647 individuals, with a mean age of 62.6 years and 52.9% of whom were female. The mean (SE) aASM (kg/m2) was 7.3 (0.04), and the mean (SE) IQS (newton) was 365.0 (3.00). After adjusting for age and gender, the correlation coefficient between aASM and IQS was 0.365 (P < 0.001). Diabetes, coronary heart disease/congestive heart failure (CHD/CHF), and vision problems were significant predictors of lower muscle strength (P < 0.05) in the multiple regression models that adjusted for age, gender, and aASM, and obesity significantly modified the relationship between aASM and IQS (P < 0.05).ConclusionsAmong individuals aged 50 and older in the US, muscle mass and muscle strength are positively correlated, independent of the associations of age and gender with muscle mass and strength. A variety of comorbid medical conditions serve as independent predictors of lower muscle strength (e.g., diabetes, CHD/CHF, vision problems) and/or modify the relationship between muscle mass and muscle strength (e.g., obesity).

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Section: Methodsmentioning

confidence: 99%

“…Muscle strength was established using measurement of the isokinetic strength of the knee extensors at peak force (isokinetic quadriceps strength [IQS]), in newtons [21]. There is evidence that lower extremity strength is associated with physical function, an important component of quality of life [25].…”

Section: Methodsmentioning

confidence: 99%

Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States

et al. 2013

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“…A randomized, double-blind, placebo-controlled study indicated that a daily diet containing four slices of a bread rich in heat-treated soy grits favorably influenced the PSA level and the free/total PSA ratio in patients with prostate cancer, which provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a decreased risk of the PSA abnormality and even prostate cancer (56) . Additionally, a cross-sectional study examining the relationship between the serum PSA level and urine phytoestrogen concentration from NHANES 2001-2004 revealed that in generally healthy US men, 40+ years old without a diagnosis of prostate cancer, urinary isoflavone and lignan concentrations were not associated with serum PSA level (57) . Similar results were found among healthy men without HRCs from NHANES 2001-2010 in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

et al. 2022

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Phytoestrogens may have potential effects on hormone-related cancers (HRCs) and cancer biomarkers, but the findings have been inconsistent so far. Participants from the National Health and Nutrition Examination Survey 1999-2010 with information on the levels of urinary phytoestrogens, serum cancer biomarkers and cancer history were included. Sampling-weighted logistic regression models examined the association between urinary phytoestrogens concentrations (creatinine-standardized and log-transformed) and HRCs, followed by stratified analyses by race/ethnicity, age and menopausal status for different gender. Correlation analyses between phytoestrogens and cancer biomarkers were performed. Of the total 8,844 participants, there were 373 with HRCs. We observed total isoflavone and enterodiol excretion was positively associated with HRCs, especially in non-Hispanic white female subpopulations (Ptrend <0.05). Similar association also existed in the total isoflavones and enterodiol levels with breast cancer. Whereas, the highest concentration of total isoflavones was significantly linked to a reduced prevalence of HRCs (OR = 0.40, 95% CI: 0.19-0.84) in white males and of prostate cancer (OR = 0.40, 95% CI: 0.18-0.86). Among 24 participants with HRCs, urinary equol concentration was positively correlated with CA15.3. Also, an inverse correlation of total PSA and positive correlation of the PSA ratio with urinary enterolactone were detected in 13 prostate cancer patients. But no significant correlation was found in all normal subjects. Our findings indicated that higher concentrations of total isoflavones and enterodiol were positively associated with HRCs. Urinary certain phytoestrogen excretion may affect serum cancer biomarker levels in cancer patients. But further prospective studies are needed to provide stronger evidence.

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“…The results showed that urinary isoflavones concentrations are not associated with serum PSA levels. [ 38 ] It seems that isoflavons may not play an important role on PSA levels reduction in PCa patients or men with clinically identified risk of PCa or healthy men.…”

Section: E Ffects Of S Oy I mentioning

confidence: 99%

Isoflavones and Prostate Cancer

Zhang

Cui

Zhang

et al. 2016

Chinese Medical Journal

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Objective:The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer (PCa).Data Sources:Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.Study Selection:Articles were selected with the search terms “isoflavone”, “Phytoestrogen”, “soy”, “genistin”, and “PCa”.Results:Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men. The effect of isoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones. The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa. Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels. In addition, it is noteworthy that isoflavones may act as an agonist in PCa.Conclusions:Isoflavones play a protective role against the development of PCa. However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa.

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Association of Urinary Phytoestrogen Concentrations with Serum Concentrations of Prostate-Specific Antigen in the National Health and Nutrition Examination Survey

Cited by 6 publications

References 46 publications

Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States

Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States

Association of urinary phytoestrogens with hormone-related cancers and cancer biomarkers: NHANES 1999–2010

Isoflavones and Prostate Cancer

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