Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis

Mikami, Risako; Mizutani, Koji; Matsuyama, Yusuke; Gohda, Tomohito; Gotoh, Hiromichi; Aoyama, Norio; Matsuura, Takanori; Kido, Daisuke; Takeda, Kohei; Saito, Natsumi; Fujiwara, Takeo; Izumi, Yuichi; Iwata, Takanori

doi:10.1371/journal.pone.0267494

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…In the recent literature, missing teeth and dental caries have a high incidence in CKD in dialysis treatment, patients under HD were found to have a high prevalence of dental caries, like we found in our study the mean values on HD group (0.56 ± 0.83) when compared with PD (0.37 ± 0.98) and P-D (0.26 ± 0.60) groups. This may be a consequence of poor oral hygiene, carbohydrate intake, alteration on the composition of the saliva and is pH, the higher risk of infection in CKH patients, the alteration of the oral micro ora (73,74).…”

Section: Discussionmentioning

confidence: 99%

Oral manifestations in different stages of chronic kidney disease

Palmeira,

Egido-Moreno,

Omaña-Cepeda

et al. 2024

Preprint

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Background Chronic kidney disease is a progressive, slow and silent disease characterized by kidney damage and a consequent reduction of kidney function. The final stage indicates that renal function is lost and necessitates renal replacement therapy for survival. This progression is associated with worsening symptoms and complications in oral cavity. The aim of this study was to investigate oral manifestations in patients with chronic kidney disease according to which stage of the disease for early detection, that alterations play an important point for dental guide during that progression. Methods The present study was a quantitative observational study of 450 patients, 150 control, 100 cases of patients in pre-dialysis, 100 cases of patients in treatment with peritoneal dialysis, 100 cases of patients in treatment with hemodialysis, from a Hospital in the north of Portugal, Oporto. An oral exam was performed for detection oral manifestations, age, smoking, alcoholic and hygiene habits, systemic diseases were collected. Results Oral lesions were presente in the four study groups, but with more incidence in the hemodialysis group. Comparing the groups studies, we found a significant finding in presence of xerostomia (45.0%), gingivitis (68.0%), petechiae (10.0%), ecchymoses (17.0%), mucosa paleness (46.0%), uremic breath (29.0%), burning mouth (9.0%), which increased as the treatment time of chronic kidney disease (peritoneal dialysis and hemodialysis) increased. Conclusion A multidisciplinary team should follow this patient, from pre-dialysis phase to kidney transplantation, the oral cavity must have important and continuous monitoring, as the early detection of lesions and specific oral manifestations could be a means of early diagnosis of chronic kidney disease or its progression. Clinical trial registration number: (Pending Registration Number) Date of clinical trial registration: 11/06/2024

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Section: Discussionmentioning

confidence: 99%

Oral manifestations in different stages of chronic kidney disease

Palmeira,

Egido-Moreno,

Omaña-Cepeda

et al. 2024

Preprint

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“…Some cross-sectional studies have addressed the fact that patients with a fewer number of teeth may be associated with increased risks of stroke or other systemic diseases [ 109 , 110 , 111 ]. On the other hand, if tooth loss is caused during the early years of life or is due to other factors such as caries or trauma, the patients might not have been affected by periodontal disease for the rest of their life [ 112 , 113 ]. In such conditions, negative health effects of poor nutrition and unhealthy eating patterns may contribute indirectly to an increased incidence of stroke [ 114 , 115 ].…”

Section: Relation Between Tooth Conditions and Strokementioning

confidence: 99%

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

Shahi

Farhoudi

Dizaj

et al. 2022

JCM

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One of the primary causes of disability and mortality in the adult population worldwide is stroke. A person’s general health is significantly impacted by their oral and dental health. People who have poor oral health are more susceptible to conditions such as stroke. Stroke risk has long been linked to oral and dental conditions. The risk of stroke and its cost impact on the healthcare systems appear to be significantly reduced as a result of the decline in the incidence and prevalence of oral and dental illnesses. Hypothetically, better management of oral hygiene and dental health lead to reduced stroke risk. To the authors’ best knowledge, for the first time, the potential link between dental health and stroke were cross-examined. The most typical stroke symptoms, oral and dental illnesses linked to stroke, and the role of oral healthcare professionals in stroke prevention are revealed. The potential mediating processes and subsequent long-term cognitive and functional neurological outcomes are based on the available literature. It must be noted that periodontal diseases and tooth loss are two common oral health measures. Lack of knowledge on the effects of poor oral health on systemic health together with limited access to primary medical or dental care are considered to be partially responsible for the elevated risk of stroke. Concrete evidence confirming the associations between oral inflammatory conditions and stroke in large cohort prospective studies, stratifying association between oral disease severity and stroke risk and disease effects on stroke survival will be desirable. In terms of clinical pathology, a predictive model of stroke as a function of oral health status, and biomarkers of systemic inflammation could be useful for both cardiologists and dentists.

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