Association of two microRNA polymorphisms miR-27 rs895819 and miR-423 rs6505162 with the risk of cancer

Abstract

Many studies have been conducted to investigate the association between miR-27 rs895819 A > G and miR-423 rs6505162 C > A and cancer risk; however, the results are not consistent. In order to acquire a more precise assessment of the correlation, we performed this meta-analysis. We searched PubMed, EMBASE and Web of Science databases to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the correlation of these two microRNA polymorphisms with cancer risk. Forty-five eligible studies from thirty-five articles were included in our analysis. The results showed that rs895819 was associated with a decreased cancer risk in Caucasians (AG vs. AA: OR = 0.87, 95% CI = 0.79-0.96; GG+AG vs. AA: OR = 0.89, 95% CI = 0.81-0.98). When grouped by ethnicity, an increased risk was observed in colorectal cancer (G vs. A: OR = 1.19, 95% CI = 1.08-1.32; GG vs. AA: OR = 1.58, 95% CI = 1.28-1.96; GG vs. AG+AA: OR = 1.58, 95% CI = 1.29-1.93), while a decreased risk was found in breast cancer (G vs. A: OR = 0.93, 95% CI = 0.87-0.99; GG+AG vs. AA: OR = 0.91, 95% CI = 0.83-0.99). For rs6505162, a significantly decreased cancer risk was observed in lung cancer under all five genetic models. To summarize, our results indicated that rs895819 was a protective factor for cancer in Caucasians and could increase colorectal cancer risk but decrease breast cancer risk. Moreover, rs6505162 was a protective factor for lung cancer.

Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

“…The protective impact of the C allele on BC development has been confirmed in several case-control studies, including in a Chinese population [C vs. A: OR = 0.628, 95% CI = 0.410-0.961, (Zhang et al, 2013); C vs. A: OR = 0.93, 95% CI = 0.87-0.99 (Zhang et al, 2017b)], German population [C vs. A: OR = 0.88, 95% CI = 0.78-0.99, P = 0.0287 (Yang et al, 2010)], and in all of the populations in a meta-analysis [C vs. A: OR = 0.91, 95% CI = 0.85-0.98, P = 0.02 (Dai et al, 2015)]. SNP rs895819 was also associated with the risk of BC in BRCA2 mutation carriers (Kontorovich et al, 2010), which indicated that this SNP may be involved in familial BC development.…”

Association between miR-27a rs895819 polymorphism and breast cancer susceptibility

“…A previous meta-analysis by Chen et al [ 25 ] involving 8 case–control studies with 3697 cases and 5013 controls found that the G-allele at rs895819 was significantly associated with decreased BC risk in the total population. Another recent meta-analysis by Zhang et al [ 26 ] including 9 case–control studies with 4191 cases and 4776 controls found that rs895819 could decrease BC risk according to the allele contrast and dominant models in the total population. In addition, a meta-analysis by Wu et al [ 27 ] including 9 case–control studies with 4499 cases and 5434 controls found that the G-allele at rs895819 is likely associated with decreased BC risk, mainly in Caucasians.…”

miR-27a Downregulation Promotes Cutaneous Squamous Cell Carcinoma Progression via Targeting EGFR

“…miR-27a abnormal expression and mutation has been identified in various malignant tumors, such as breast, renal and colorectal cancer (13,17,18). miR-27a decreased the risk of breast cancer in Caucasians (17) and population with the genetic variant of pre-miR-27a had a lower risk of renal cell carcinoma (RCC) (13). Further, low expressed miR-27a was related to high grade in colorectal cancer (18).…”