Association of tumor necrosis factor alpha, interferon gamma and interleukin 10 gene polymorphisms with peripheral neuropathy in South Indian patients with type 2 diabetes

Kolla, Venkata Karunakar; Madhavi, G.; Reddy, B. P. Niranjan; Babu, B. M. V. Srikanth; Yashovanthi, J.; Valluri, Vijaya Lakshmi; Ramesh, J.; Jyothy, A.

doi:10.1016/j.cyto.2009.06.007

Cited by 56 publications

(43 citation statements)

References 36 publications

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“…In accordance with previous studies on T2DM [21][22][23][24][25][26][27][28][29][30], we found no association between TNF-α −308G/A polymorphism and T2DM. Although Heijmans et al reported that this polymorphism was associated with T2DM in Dutch people, their patients were aged 85 years and over, which suggests that age contributed to this result, because adverse effects of mild alterations in TNF-α expression become apparent only in old age [31].…”

Section: Discussionsupporting

confidence: 82%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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Abstract. The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-α gene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR-RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07-2.29; p = 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05-2.31; p = 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

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Section: Discussionsupporting

confidence: 82%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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“…10,[19][20][21][22] These current findings are consistent with several studies. 23,24 One study conducted in India indicated that the IL10 gene À1082 A/G genotype significantly increased the risk of type 2 diabetes mellitus. 23 Another study from Iran found that the IL10 gene polymorphism À592 A/C was associated with Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…23,24 One study conducted in India indicated that the IL10 gene À1082 A/G genotype significantly increased the risk of type 2 diabetes mellitus. 23 Another study from Iran found that the IL10 gene polymorphism À592 A/C was associated with Table 2. Genotype frequencies of three single nucleotide polymorphisms (SNP) of the interleukin 10 (IL10) gene in patients with type 2 diabetes mellitus and healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Bai¹,

Jing²,

Guo³

et al. 2014

J Int Med Res

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Objective: To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population. Methods: This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the À1082 G/A (rs1800896), À819 T/C (rs1800871) and À592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups. Results: The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the À1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the À592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the À1082 GA þ GG and À592 AC þ AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15). Conclusions: The SNPs À1082G/A and À592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.

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“…Some studies have proposed a protective role for IL-10 in diabetic retinopathy [35] and a mouse model of diet-induced insulin resistance [36]. On the other hand, it has also been reported an association between diabetic neuropathy and a single nucleotide polymorphism in the IL-10 gene that results in higher production of this cytokine [37].…”

Section: Discussionmentioning

confidence: 99%

Neuropathy-specific alterations in a Mexican population of diabetic patients

et al. 2017

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Background: Neuropathy is one of the major complications of type 2 diabetes mellitus. Our first aim was to determine the clinical characteristics of a population of diabetic patients with different types of neuropathy. Our next goal was to characterize the cytokine profile (IL-6 and IL-10), nerve growth factor (NGF) and circulating celladhesion molecules in these patients. Finally, we aimed to compare the renal function among the groups of neuropathic patients. Methods: In a cross-sectional study, we included 217 diabetic patients classified in three groups: sensory polyneuropathy with hypoesthesia (DS h P) or hyperesthesia (DS H P), and motor neuropathy (DMN). Two control groups were included: one of 26 diabetic non-neuropathic patients (DNN), and the other of 375 non-diabetic (ND) healthy subjects. The participants were attending to the Mexican Institute of Social Security. Results: The circulating levels of NGF were significantly lower in diabetic patients, compared to healthy subjects. The range of IL-6 and IL-10 levels in neuropathic patients was higher than the control groups; however, several samples yielded null measurements. Neuropathic patients also showed increased circulating levels of the adhesion molecules ICAM, VCAM, and E-Selectin, compared to the ND group. Moreover, neuropathic patients showed reduced glomerular filtration rates compared to healthy subjects (82-103 ml/min per 1.73 m 2 , data as range from 25th-75th percentiles), especially in the group with DMN (45-76 ml/min per 1.73 m 2 ).

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Association of tumor necrosis factor alpha, interferon gamma and interleukin 10 gene polymorphisms with peripheral neuropathy in South Indian patients with type 2 diabetes

Cited by 56 publications

References 36 publications

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Neuropathy-specific alterations in a Mexican population of diabetic patients

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