Association of Tissue Mast Cells and Skin Tumors

Immune‐associated cells in basal cell carcinomas of skin

“…Only rarely were MCs seen infiltrating tumor nests. This finding is in agreement with an earlier report by Cawley & Hoch-Ligeti who noted increased numbers of MCs in BCCs and other tumors (12). The importance and role for the MC in tumors has been debated over the last several years.…”

Mast Cell Numbers in Multiple Dermatofibromas

“…The number of mast cells has been reported to be in creased in solitary DF [11]. However, in 2 of our 3 cases with multiple DFs.…”

Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: action through Ca2(+)-mobilizing H1 receptors.

“…The present findings also suggest that histamine-secreting mast cells may have a more important role in modulating cell proliferation than has been assured to date. Indeed, the finding that mast cells are frequently abundant in the contiguous tissue of metastatic tumors supports this possibility (7).…”