1961
DOI: 10.1001/archderm.1961.01580070098010
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Association of Tissue Mast Cells and Skin Tumors

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Cited by 62 publications
(22 citation statements)
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“…Baroni [1] reported increased mast cell numbers in several tumors, including neurofibromas, lipomas, and hemangiomas, a result later confirmed by Glowacki and Mulliken [2] and by Ho [3]. Increased numbers of mast cells have also been reported in human adrenocortical tumors [4] and in a variety of skin tumors [5]. In experimental animals, mast cell infiltration and degranulation were observed to be concurrent with the development of epidermoid carcinomas in carcinogen-treated hamsters [6] and were seen at the periphery of tumors implanted onto the chorioallantoic membranes of chick embryos [7].…”
Section: Introductionmentioning
confidence: 81%
“…Baroni [1] reported increased mast cell numbers in several tumors, including neurofibromas, lipomas, and hemangiomas, a result later confirmed by Glowacki and Mulliken [2] and by Ho [3]. Increased numbers of mast cells have also been reported in human adrenocortical tumors [4] and in a variety of skin tumors [5]. In experimental animals, mast cell infiltration and degranulation were observed to be concurrent with the development of epidermoid carcinomas in carcinogen-treated hamsters [6] and were seen at the periphery of tumors implanted onto the chorioallantoic membranes of chick embryos [7].…”
Section: Introductionmentioning
confidence: 81%
“…[9][10][11][12][13][14] The increased density of mast cells around many types of tumors is independent of the presence of an inflammatory infiltrate. 26 Cohen et al 27 find that the degree of peribasal cell carcinoma inflammation does not correlate with the relative density of mast cells.…”
Section: Mast Cell Density Around Cutaneous Malignanciesmentioning
confidence: 99%
“…6 Studies have shown that mast cells accumulate around the margin of these cutaneous malignancies. [9][10][11][12][13][14] There is compelling evidence that mast cell accumulation among the peritumoral inflammatory infiltrates contributes to a permissive microenvironment for carcinogenesis and metastasis. [15][16][17] Mast cells originate from the bone marrow and the immature progenitor cells migrate to peripheral tissues and mature in situ.…”
mentioning
confidence: 99%
“…[13][14][15][16][17][18][19][20][21] In some instances, NF1 neurofibroma mast cells have been quantified and there is consistently an excess compared to normal tissue. 22,23 However, no attempts seem to have been made to identify the tissue source or detailed nature of the NF1 neurofibroma's mature mast cells, for example, tryptase or chymase predominance.…”
Section: Reviewmentioning
confidence: 99%