2014
DOI: 10.18632/aging.100703
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Abstract: Human lifespan is determined greatly by genetic factors and some investigations have identified putative genes implicated in human longevity. Although some genetic loci have been associated with longevity, most of them are difficult to replicate due to ethnic differences. In this study, we analyzed the association of 18 reported gene single nucleotide polymorphisms (SNPs) with longevity in 1075 samples consisting of 567 nonagenarians/centenarians and 508 younger controls using the GenomeLab SNPstream Genotypin… Show more

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Cited by 20 publications
(14 citation statements)
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References 31 publications
(23 reference statements)
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“…[ 29 ] confirmed a known association of the IGFBP3 gene with IGFBP-3 levels and a borderline significant association between IGF-I concentration and FOXO3 ; rs2153960 and longevity. Similarly, He et al [ 30 32 ] reported an association of IGFBP3 ; rs11977526 gene polymorphism with longevity phenotype in a Chinese cohort, which was different from our studied polymorphism (rs2854744). Deal et al [ 31 ] found in 478 men from the Physicians’ Health Study that the A allele had higher promoter activity at the –202 locus compared with the C allele of IGFBP3 gene polymorphism, which is consistent with the relationship observed between genotype and circulating IGFBP-3.…”
Section: Discussioncontrasting
confidence: 91%
“…[ 29 ] confirmed a known association of the IGFBP3 gene with IGFBP-3 levels and a borderline significant association between IGF-I concentration and FOXO3 ; rs2153960 and longevity. Similarly, He et al [ 30 32 ] reported an association of IGFBP3 ; rs11977526 gene polymorphism with longevity phenotype in a Chinese cohort, which was different from our studied polymorphism (rs2854744). Deal et al [ 31 ] found in 478 men from the Physicians’ Health Study that the A allele had higher promoter activity at the –202 locus compared with the C allele of IGFBP3 gene polymorphism, which is consistent with the relationship observed between genotype and circulating IGFBP-3.…”
Section: Discussioncontrasting
confidence: 91%
“…low) grade disease. In addition, a few of the strong instruments validated in this study were associated with all‐cause mortality under a non‐additive genetic model (on the basis on an earlier report of non‐additivity in the relationship of rs11977526 and longevity34). On the other hand, rs700752 exhibited the strongest association with prostate cancer‐specific mortality under an additive model.…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, individuals with exceptional longevity are enriched with functional mutations in the IGF1R gene, which confer partial IGF-1 resistance (Suh et al, 2008; Tazearslan et al, 2011). Variants in AKT1 and FOXO3A genes, which are elements of the GH/IGF-1 signaling pathway, have been identified in long-lived individuals from several different cohorts of diverse ethnic backgrounds, although their functional role has not yet been defined (He et al, 2014; Pawlikowska et al, 2009). Furthermore, centenarians exhibit a higher than age-predicted level of a specific microRNA, hsa-miR-363*, which regulates AKT1 and IGFBP-5 (Gombar et al, 2012).…”
Section: Human “Models” Of Gh/igf-1 Attenuation and Agingmentioning
confidence: 99%