Britta Schürmann, Birgitt Wiese, Horst Bickel, Siegfried Weyerer, Steffi G. Riedel-Heller, Michael Pentzek, Cadja Bachmann, Julie Williams, Hendrik van den Bussche, Wolfgang Maier, Frank Jessen
Abstract:A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0…
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