Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population

Daimon, Makoto; Kido, Takashi; Baba, Masanori; Oizumi, Toshihide; Jimbu, Yumi; Kameda, Wataru; Yamaguchi, Hiroshi; Ohnuma, Hiroshi; Tominaga, Makoto; Muramatsu, Masaaki; Kato, Takeshi

doi:10.1016/j.bbrc.2005.01.119

Cited by 41 publications

(37 citation statements)

References 27 publications

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“…Carriers of loss-of-function mutations in ABCA1, however, do display pancreatic beta cell dysfunction [22], indicating the importance of functional ABCA1 in beta cell function. In addition, several SNPs in ABCA1 have been reported to be associated with diabetes as well as decreased HDL levels [23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

et al. 2010

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Aims/hypothesis Cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol efflux leads to beta cell dysfunction. In this study, we aimed to determine the role of the LDL receptor (LDLr) in islet cholesterol uptake and to assess the contributions of cholesterol uptake compared with efflux to islet cholesterol levels. Methods Islet cholesterol and beta cell function were assessed in mice lacking LDLr (Ldlr

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Section: Discussionmentioning

confidence: 99%

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

et al. 2010

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“…We previously demonstrated that myeloid cell-specifi c deletion of ABCA1 results in increased macrophage infl ammatory response to TLR agonists ( 24 ), and human studies suggest an association between ABCA1 single nucleotide polymorphisms, leukocyte ABCA1 expression, and insulin resistance (17)(18)(19)(20)(21)(22). However, whether there is a link between macrophage ABCA1-regulated innate immunity and insulin resistance is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin resistance has not been documented in people with Tangier disease, perhaps because the disease is so rare ( 16 ). However, ABCA1 single nucleotide polymorphisms are associated with altered glucose metabolism and insulin resistance in humans (17)(18)(19)(20). Of interest, leukocyte ABCA1 gene expression is associated with fasting glucose concentrations in normoglycemic men, and reduced leukocyte ABCA1 gene expression is associated with type 2 diabetes ( 21,22 ).…”

Section: Immunohistochemistry Stainingmentioning

confidence: 99%

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models

Zhu

Chung

et al. 2013

Journal of Lipid Research

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“…Author defined the data object specification for relevant information processing and information derivation. Takashi Kido [2] defined a work on pattern specification and mining under information disease identification with associated constraint specification. Bernard J. Vigier [3] provided a way to separate the damage identification on rot infection and provided the analysis on the low level information processing and generating the information narrow band so that the feature improved extraction will be obtained.…”

Section: Existing Workmentioning

confidence: 99%

A Neuro-Fuzzy Integrated Clustering for Weather Knowledge Analysis

Dahiya¹,

Gigras²

2015

IJCA

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Weather Information processing and knowledge extraction is one of the challenging applications of data mining. This process area requires authenticated and intelligent processing to obtain accurate information from the knowledge set. In this work, an intelligent clustering mechanism is defined to acquire such information. This neuro-fuzzy based model is applied on raw dataset defined with various weather characteristics including humidity, temperature, rainfall etc. The work is divided in three main stages. In first stage, the filtration over the dataset is performed to get more relevant information set. In second stage, the clustering is performed to divide the information set in knowledge groups. In final stage, the filtration over the knowledge set is performed to acquire the most effective knowledge. The results show the effective information analysis is obtained from the work.

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Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population

Cited by 41 publications

References 27 publications

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models

A Neuro-Fuzzy Integrated Clustering for Weather Knowledge Analysis

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