Association of testosterone and bone mineral density with tooth loss in men with chronic periodontitis

Abstract

A study was conducted to compare the mean testosterone and bone mineral density (BMD) levels in men with and without tooth loss. Two hundred three male subjects aged 30-65 years satisfying the study criteria were selected and then examined for bone mineral density, testosterone level, clinical attachment loss, probing pocket depth, tooth mobility and tooth loss due to periodontal disease. Statistical analysis was performed using the Statistical Package for Social Sciences (version 15.0) (SPSS Inc., Chicago, Ill, USA), and differences were considered to be significant at P < 0.05. Independent sample "t" test was used to compare the results, and receiveroperator curve (ROC) analysis was performed to obtain the cut-off. The mean testosterone level in subjects without tooth loss was 4.41 ± 2.57, whereas that in subjects with tooth loss was 2.79 ± 1.15 (P = 0.001). The mean BMD in subjects without tooth loss was 0.99 ± 0.13, whereas that in subjects with tooth loss was 0.96 ± 0.12 (P = 0.046). The testosterone level and BMD in subjects with tooth loss were significantly lower than those in subjects without tooth loss. Testosterone is a good predictor of tooth loss, but its efficiency decreases with increasing tooth loss. BMD is not a good predictor of tooth loss. (J Oral Sci 53, 333-339, 2011)

Prospective association of sex steroid concentrations with periodontal progression and incident tooth loss

“…)) did not find any association between testosterone levels and periodontal disease or tooth loss, whereas positive studies were exclusively cross‐sectional ones (Jeffcoat , Singh et al. ). Considering that only longitudinal studies are suitable to assess the relationship and its temporal sequence properly, we conclude that the current evidence for an association needs to be interpreted with care and supports the notion, that systemic testosterone levels are not associated with periodontal disease and tooth loss.…”

“…, Jeffcoat , Singh et al. ). In subjects with fewer teeth testosterone concentrations were significantly lower than in subjects with a complete dentition (Orwoll et al.…”

“…) and tooth loss (Singh et al. ). In women, testosterone is among the most potent sex hormones (Guay & Davis ) and is suggested to be related to a wide range of diseases and conditions (Ding et al.…”

Impact of aging on TREM-1 responses in the periodontium: a cross-sectional study in an elderly population

“…The prevalence of mild to moderate periodontitis among the elderly is high [11, 12]. Inflammatory mediator levels generally exhibit age-related changes, even in the absence of acute infection or other physiologic stress [13]. A significant relationship exists between aging, inflammation, response to infection, and progression of chronic, inflammatory diseases [14].…”

Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor

“…Periodontitis is one of the most prevalent infectious diseases affecting as many as 75% of adult and elderly populations, and it eventually leads to loss of teeth. In earlier studies, the results on the association of sex steroids and periodontitis or tooth loss have been contradictory (22,23), but the subject is rarely investigated.…”