PLoS ONE volume 9, issue 5, Pe98280 2014 DOI: 10.1371/journal.pone.0098280 View full text
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Jingyu Liao, Qi Zhang, Yun Liao, Bei Cai, Jie Chen, Lixin Li, Lanlan Wang

Abstract: PurposeT-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cells in hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). However, few researches have reported the association of Tim-3 genetic variants with susceptibility and progression of HBV infection. In this study, we focused on the association of Tim-3 polymorphisms with HBV infection, HBsAg seroclearance and hepatocellular carcinoma.MethodsA total of 800 subjects were involved in t…

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