Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: Results from NHANES

Cao, Ye‐Xuan; Li, Pengxiao; Zhang, Yan; Qiu, Miaohan; Li, Jing; Ma, Sicong; Yan, Yudong; Li, Yang; Han, Yaling

doi:10.3389/fimmu.2023.1087345

Cited by 42 publications

(35 citation statements)

References 48 publications

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“…The associations of SII with cancer and all-cause mortality showed the same trend. The same phenomenon was observed in a previous study of SII in hypertensive patients in the NHANES database in relation to all-cause mortality and cancer mortality (25), suggesting that low levels of immune in ammation in the body is another risk factor for…”

Section: Discussionsupporting

confidence: 86%

“…Interestingly, the analysis showed that there was a little change of cardiovascular mortality with SII in cancer patients before the threshold (p 0.05), after which high SII levels were associated with high mortality. This has been reported for the rst time in cancer patients, but there are similarities to studies in other populations (25)(26)(27).…”

Section: Discussionsupporting

confidence: 83%

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Association of systemic immune-inflammatory index with cancer prevalence and mortality: Results from NHANES 1999-2010

Zhang,

Jia,

Lan

et al. 2023

Preprint

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Objective: To study the predictive effect of systemic immune-inflammatory index (SII) on cancer prevalence and mortality. Methods: Participants with SII and cancer status were screened from the National Health and Nutrition Examination Survey database from 1999 to 2010, and their baseline characteristics were analyzed according to the SII tertile. Multivariable logistical or Cox proportional hazards models were used to analyze the associations between SII with cancer prevalence or mortality. The mortality was followed through December 31 2018. For further evaluation on associations of SII with specified outcomes, restricted cubic spline and two piecewise regression models were adopted. Results: This study eventually included 26,049 individuals, of whom 2,432 were cancer patients. According to the SII tertile group, cancer prevalence increased significantly with the rise of SII. In the highest tertile of SII, SII was significantly related to cancer prevalence (OR=1.45, 95%CI= 1.31 - 1.61, p<0.05). Moreover, during a median follow-up of 12.75 year, 329, 351, and 1,202 cardiovascular, cancer and all-cause deaths occurred among cancer patients, respectively. The results indicated that highest level of SII was significantly associated with increased cardiovascular mortality (HR=1.80, 95%CI= 1.28 - 2.52), cancer mortality (HR=1.64, 95%CI= 1.28 - 2.09) and all-cause mortality (HR=1.56, 95%CI= 1.31- 1.85). The model adjusted for multiple covariates still showed the same trend. U-shaped dose-response associations between log-transformed SII (ln-SII) with prevalence and mortality of cancer were detected. The threshold values of ln-SII for the lowest risk associated with cancer prevalence, cardiovascular mortality cancer mortality and all-cause mortality were 5.44, 6.21, 6.27 and 6.21, respectively. Above thresholds, SII was positively associated with increased risk of above outcomes. Conclusion: SII may be a potential earlier warning marker for the prevalence and mortality of total cancers.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 83%

Association of systemic immune-inflammatory index with cancer prevalence and mortality: Results from NHANES 1999-2010

Zhang,

Jia,

Lan

et al. 2023

Preprint

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“…As clearly shown in Figure 6, the risk of LEDVT first decreased and then increased rapidly with the rise of ln(SII). Although no previous study has investigated the dose-response relationship, similar non-linear associations were found between SII and risk of all-cause mortality (35,36), arrhythmias (37), and rheumatoid arthritis (38). In these studies, the threshold values of ln(SII) were 5.97 × 10 9 /L (35), 6.57 × 10 9 /L (36), and 6.36 × 10 9 /L (38), respectively.…”

Section: Discussionmentioning

confidence: 55%

Association between systemic immune-inflammation index and risk of lower extremity deep venous thrombosis in hospitalized patients: a 10-year retrospective analysis

Chen

Wang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundThe systemic immune-inflammation index (SII), as a novel inflammatory biomarker, has recently attracted attention in cardiovascular disease research. However, the relationship between SII and risk of lower extremity deep venous thrombosis (LEDVT) remains unclear to date. Thus, this study aimed to explore the association in a large sample over a 10-year period (2012–2022).MethodsAll hospitalized patients undergoing lower extremity compression ultrasonography (CUS) examination were consecutively screened by searching our hospital information system database. The receiver operating characteristic (ROC) curve analysis was used to identify the optimal cut-off value for high and low SII group. Multivariate logistic regression analyses were performed to investigate the relationship between SII and LEDVT risk. Propensity score matching (PSM), subgroup and sensitivity analyses were also conducted. Moreover, restricted cubic spline (RCS) regression and two-piecewise linear regression models were used to assess the dose-response relationship between natural log transformed SII [ln(SII)] and risk of LEDVT.ResultsA total of 16,725 consecutive hospitalized patients were included, and 1,962 LEDVT events occurred. After adjusting for confounding factors, patients in the high SII group (≥ 574.2 × 109/L) showed a 1.740-fold risk of LEDVT (95% CI: 1.546–1.959, P < 0.001), and elevated ln(SII) was associated with a 36.1% increased risk of LEDVT (95% CI: 1.278–1.449, P < 0.001). PSM, subgroup and sensitivity analyses confirmed the robustness of the association. A non-linear relationship was observed (Pnon−linear < 0.001), with a threshold value of 5.6 × 109/L for all LEDVT events. Above the threshold, each unit increase in ln(SII) had a 1.369-fold higher risk of LEDVT (95% CI: 1.271–1.475, P < 0.001). The association also existed in both distal and proximal LEDVT.ConclusionElevated SII is significantly associated with an increased risk of LEDVT in hospitalized patients. Additionally, the association is non-linear and exhibit a threshold effect.

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“…The possible pathways include oxidative stress and immune-inflammation. 8,16,17 Numerous epidemiolog-ical studies have found that higher levels of heavy metals, including Pb and Cd, are associated with increased levels of systemic inflammatory biomarkers such as C-reactive protein (CRP), white blood cells, and eosinophils. 18,19 Heavy metals are considered environmental endocrine disruptors, which elevate systemic inflammation and promote metabolic disease.…”

Section: Introductionmentioning

confidence: 99%

“…However, the mechanisms underlying these consistent associations remain unclear. The possible pathways include oxidative stress and immune‐inflammation 8,16,17 . Numerous epidemiological studies have found that higher levels of heavy metals, including Pb and Cd, are associated with increased levels of systemic inflammatory biomarkers such as C‐reactive protein (CRP), white blood cells, and eosinophils 18,19 .…”

Section: Introductionmentioning

confidence: 99%

Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk

Du,

Deng,

Cai

et al. 2023

Journal of Periodontology

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BackgroundThis study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.MethodsPooled cross‐sectional data from the National Health and Nutrition Examination Survey (NHANES 2009‐2014) were used (n = 8993). Periodontitis was defined by a full‐mouth examination and classified as no/mild and moderate/severe (mod/sev) groups. Blood and urinary heavy metal levels were investigated, including cadmium (Cd), lead (Pb), and mercury (Hg). In addition, systemic inflammation was assessed using circulatory leukocyte counts and C‐reactive protein (CRP) levels.ResultsMultivariable logistic regression analysis revealed the positive associations of blood and urinary levels of Cd and Pb with mod/sev periodontitis. In contrast,blood Hg levels did not show a significant association. The odds of having periodontitis were 1.233 and 1.311 times higher for each one‐unit increment in Ln‐transformed blood Cd (95% confidence interval [CI]: 1.109–1.371) and Pb (95% CI: 1.170‐1.470), respectively. Mediation analysis suggested a 6.3% to 11.5% contribution of leucocyte counts in the association of blood Cd and Pb levels with periodontitis. Sensitivity analyses for urinary Cd levels yielded consistent mediating effects. However, no significant mediating effect of CRP was detected.ConclusionHigher exposures to Cd and Pb were positively associated with periodontitis risk. These associations might be partially mediated by the elevated levels of leukocytes rather than CRP. Further longitudinal studies are needed to elucidate the discordant results of the systemic inflammatory biomarkers.

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Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: Results from NHANES

Cited by 42 publications

References 48 publications

Association of systemic immune-inflammatory index with cancer prevalence and mortality: Results from NHANES 1999-2010

Association of systemic immune-inflammatory index with cancer prevalence and mortality: Results from NHANES 1999-2010

Association between systemic immune-inflammation index and risk of lower extremity deep venous thrombosis in hospitalized patients: a 10-year retrospective analysis

Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk

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