Association of specific frequency bands of functional MRI signal oscillations with motor symptoms and depression in Parkinson’s disease

Abstract

A novel empirical mode decomposition method was adopted to investigate the dissociative or interactive neural impact of depression and motor impairments in Parkinson’s disease (PD). Resting-state fMRI data of 59 PD subjects were first decomposed into characteristic frequency bands, and the main effects of motor severity and depression and their interaction on the energy of blood-oxygen-level-dependent signal oscillation in specific frequency bands were then evaluated. The results show that the severity of motor symptoms is negatively correlated with the energy in the frequency band of 0.10–0.25 Hz in the bilateral thalamus, but positively correlated with 0.01–0.027 Hz band energy in the bilateral postcentral gyrus. The severity of depression, on the other hand, is positively correlated with the energy of 0.10–0.25 Hz but negatively with 0.01–0.027 Hz in the bilateral subgenual gyrus. Notably, the interaction between motor and depressive symptoms is negatively correlated with the energy of 0.10–0.25 Hz in the substantia nigra, hippocampus, inferior orbitofrontal cortex, and temporoparietal junction, but positively correlated with 0.02–0.05 Hz in the same regions. These findings indicate unique associations of fMRI band signals with motor and depressive symptoms in PD in specific brain regions, which may underscore the neural impact of the comorbidity and the differentiation between the two PD-related disorders.

Brain structural changes associated with aberrant functional responses to the Valsalva maneuver in heart failure

“…Active forced expiration, which is the motoric component, induced significant neural responses in motor control areas in healthy controls, including the bilateral motor cortices, supplementary motor area, cerebellar, and striatum (Figure a); however, these areas showed less activation in HF subjects (Figure b,c), indicating less involvement in motor control. The disruption of the striatal‐cortical‐cerebellar circuit will result in ataxia, difficulties in smooth pursuit of action, and other movement disorders (Hu, Song, Li, et al, ; Song et al, ). HF patients show multiple motoric impairments, such as dysfunctions in complex planning, spatial attention, motor speed, grip strength, and gait (Davies, Greig, Jordan, Grieve, & Lipkin, ; Notarius et al, ).…”

“…Another common comorbid characteristic of HF is high incidence of depression or depressive symptoms (40–60%) (Jiang et al, ). Several brain regions, including the middle and posterior cingulate cortices, vMPFC, and parietal areas, are damaged in subjects with depression (Hu, Song, Li, et al, ; Song et al, ). Brain tissue changes in these sites would exert prominent emotional and behavioral effects on HF subjects as reported in the condition (Hou, Song, et al, ; Hou, Sui, Song, & Yuan, ; Hou, Wang, et al, ).…”

Altered resting‐state hippocampal and caudate functional networks in patients with obstructive sleep apnea

“…Resting‐state functional MRI techniques have been widely applied in various clinical studies of psychiatric symptoms and other neurological issues (Hu, Song, Li, et al., ; Hu, Song, Yuan, et al., ; Song et al., ), and thus, may be useful in assessing network‐level changes in OSA subjects. Functional connectivity (FC), a measurement that quantifies statistical dependency between the functional time series of anatomically distinct brain sites, is a robust way to assess functional network integrity.…”

Impaired interhemispheric synchrony in Parkinson’s disease with depression

“…During the last decade, many structural and functional neuroimaging studies have attempted to explore the possible mechanisms of depression in PD 8 9 10 11 12 13 14 15 16 . Structural neuroimaging studies showed that PD patients with depression displayed grey matter loss and white matter reduction in the prefrontal, temporal and some limbic regions 8 9 10 .…”