Association of sleep duration with kidney function and albuminuria: NHANES 2009-2012

Abstract

In a US representative sample of adults, self-reported short and long sleep duration were related to higher ACR. Short sleep duration was associated with higher eGFR and microalbuminuria. Research is needed to understand whether these associations indicate increased risk for kidney damage and cardiovascular risk.

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women

“…Based on sample size, these studies were also underpowered to assess the dose-response relationship. We found only one study that has investigated the association between sleep duration and glomerular hyperfiltration using a nationally representative sample in the United States [30]. In that study, the association differed by race-ethnicity, and long sleep duration was significantly related to glomerular hyperfiltration among Mexican Americans.…”

Self-reported sleep duration and daytime napping are associated with renal hyperfiltration and microalbuminuria in apparently healthy Chinese population

“…Several studies had investigated the association between sleep and kidney health outcome. Both short and long sleep duration were reported to be associated with decreased eGFR and the progression to ESRD among CKD 12, 21, 32, 33 or hypertension 18 population, and to be associated with increased eGFR, hyperfiltration, inadequate hydration and the prevalence of CKD among community-based general population 13, 19, 20, 26–28 . In our study, based on same general community population, we further demonstrated that inappropriate sleep duration had converse effects on eGFR in healthy or early-stage nephropathy population, which was consistent to previous studies.…”

“…A few studies selected albuminuria as a terminal outcome to evaluate how sleep affects kidney function. Both short and long sleep duration had been reported to be associated with UACR level among populations from Japan 35 , Korea 36 and US 12 , and daytime napping had been reported to be positively associated with albuminuria in Japan 37 , however, this relationship is racial-specific 13 , whether it exists among Chinese population keeps unknown. This study confirmed the U-shaped relationship between sleep duration and albuminuria and the positive relationship between napping and albuminuria on the basis of the Chinese population.…”

“…Recently, a series of studies suggested extreme sleep duration may contribute to the decline of kidney function, which is closely tied to the vascular system, also an important, independent risk factor for cardiovascular disease. Both extremely short 11, 12 and long 13 sleep duration and poor sleep quality 14, 26 were reported to be related to higher urine albumin-to-creatinine ratio(UACR), which is a sensitive indicator for microalbuminuria or early stage of kidney damage, among US and Japanese population. In addition, short sleep duration was associated with higher odds of inadequate hydration 15 .…”

“…Several studies have demonstrated an increasing risk of CKD16,17 or lower GFR12,18,19,20,21 in short sleepers, but a few studies have shown no correlation between sleep duration and CKD22-25. Conversely, there were both cross-sectional or cohort studies which have reported inappropriate sleep duration contributes to glomerular hyperfiltration 13, 26–28 . This difference in outcomes can be attributed not only to differences in race, age, social work stress, health and economic status of the participants, but also to the fact that in the progression of CKD, healthy individuals tend to have glomerular hyperfiltration initially, followed by increased risk for renal injury, leading to a decrease in filtration rate and accelerating development of CKD.…”