2011
DOI: 10.1038/aps.2011.26
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Abstract: Aim: Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD. Methods: One hundred and fifty five patients with CAD were divided into two group… Show more

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Cited by 123 publications
(97 citation statements)
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“…Omentin-1 may be involved in vascular disease due to its effect on endothelial function, vasodilatation, arterial compliance and calcification, and inflammation. 11,12,21,22 We did not find any correlation between omentin-1 and carotid IMT (mean) . In subgroup analysis, omentin-1 levels were lower in patients with carotid plaque than without carotid plaque.…”
Section: Discussioncontrasting
confidence: 56%
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“…Omentin-1 may be involved in vascular disease due to its effect on endothelial function, vasodilatation, arterial compliance and calcification, and inflammation. 11,12,21,22 We did not find any correlation between omentin-1 and carotid IMT (mean) . In subgroup analysis, omentin-1 levels were lower in patients with carotid plaque than without carotid plaque.…”
Section: Discussioncontrasting
confidence: 56%
“…Furthermore, the levels of omentin-1 are decreased in patients with atherosclerotic vascular disease. 14,[20][21][22]30 Taking into consideration the above associations, the effect of insulin sensitizing drugs and weight loss on omentin-1 have been studied and increases in omentin-1 levels are found after metformin treatment and weight loss. 31,32 The other important factor regulating omentin-1 is inflammation.…”
Section: Discussionmentioning
confidence: 99%
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“…Serum omentin-1 concentrations were reported to correlate passively with BMI and waist circumference [5] . Decreased serum level of omentin-1 was reported in polycystic ovary syndrome [6] , diabetes [7] and coronary artery disease [8] . Moreover, omentin was reported to prevent apoptosis of cardiomyoblasts via inhibition of mitochondrial ROS production [9] .…”
Section: Introductionmentioning
confidence: 99%
“…Omentin increases the sensitivity of adipocytes to insulin, and increasing obesity and insulin resistance have been correlated with lower levels of omentin (18,19). Furthermore, individuals with coronary artery disease and rheumatoid arthritis have reduced omentin levels (20,21). In addition, omentin suppresses the ERK/NF-κB pathway to promote vasodilation in blood vessels of rats and diminishes the expression of adhesion molecules triggered by TNF-α in endothelial cells (22,23).…”
Section: Introductionmentioning
confidence: 99%