Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients

Ülgen, F; Herder, Christian; Kühn, Markus C.; Willenberg, Holger S.; Schott, M.; Scherbaum, Werner A.; Schinner, Sven

doi:10.3109/13813451003631421

Cited by 44 publications

(44 citation statements)

References 26 publications

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“…Higher circulating levels of leptin and adiponectin are found in women (82,83). On the contrary, higher levels of circulating RBP4 are described in men (35,37,65,67,72). This dimorphism was, however, not shown in all studies (32,73,84,85).…”

Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 60%

“…In several studies, circulating RBP4 levels also did not correlate with insulin resistance, impaired glucose tolerance, T2D, or altered insulin secretion (10,72,(74)(75)(76)(77). In adipose tissue and muscle, insulin-sensitizing agent pioglitazone unexpectedly increased RBP4 gene expression (10).…”

Section: Rbp4 In Childhood/adolescent Obesity and Insulin Resistancementioning

confidence: 99%

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RBP4: a controversial adipokine

Kotnik

Fischer‐Posovszky

Wabitsch

2011

European Journal of Endocrinology

210

165

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Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.

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Section: Sex-specific Dimorphism Of Rbp4mentioning

confidence: 60%

Section: Rbp4 In Childhood/adolescent Obesity and Insulin Resistancementioning

confidence: 99%

RBP4: a controversial adipokine

Kotnik

Fischer‐Posovszky

Wabitsch

2011

European Journal of Endocrinology

210

165

View full text Add to dashboard Cite

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“…In addition to lower insulin sensitivity, a negative effect on secretion of β-cells caused by RBP4 is suggested. On the other hand, there is a variety of recent studies that did not find in RBP4 an accurate biomarker of IR and MS in diabetic or normal subjects (26)(27)(28).…”

Section: Introductionmentioning

confidence: 97%

Serum levels of retinol binding protein 4 in women with different levels of adiposity and glucose tolerance

Comucci

Vasques

Geloneze

et al. 2014

Arq Bras Endocrinol Metab

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Objective: Retinol-binding protein 4 (RBP4) is an adipokine responsible for vitamin A (retinol) transportation. Studies associated RBP4 increased levels with severity of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). The study aimed to quantify RBP4 serum standards in women with a wide range of body mass index (BMI) and glucose tolerance level. Subjects and methods: Cross-sectional study was performed with 139 women divided into three groups: Group 1 (lean-control, n = 45) and Group 2 (obese, n = 53) with normal glucose tolerance and group 3 (obese with T2DM, n = 41), called G1, G2 and G3. Were assessed clinical, biochemical, anthropometric and body composition parameters. Results: According to data analysis, we obtained in G1 higher RBP4 levels (104.8 ± 76.8 ng/mL) when compared to G2 (87.9 ± 38 ng/mL) and G3 (72.2 ± 15.6 ng/mL) levels. Also, were found: in G1 positive correlations of RBP4 with BMI (r = 0.253), glycated hemoglobin (r = 0.378) and fasting insulin (r = 0.336); in G2 with glycated hemoglobin (r = 0.489); in G3 with glycated hemoglobin (r = 0.330), fasting glucose (r = 0.463), HOMA-IR (r = 0.481). Conclusions: Although RBP4 have shown lower levels in diabetic and obese, a strong correlation with HOMA-IR index highlights that, in our study, there is growing IR when there is an increasing in RBP4 levels. Arq Bras Endocrinol Metab. 2014;58(7):709-14 Keywords Obesity; metabolic syndrome; insulin resistance; women; premenopause RESUMO Objetivo: A proteína carreadora do retinol 4 (RBP4) é uma adipocina responsável pelo transporte de vitamina A (retinol). Estudos associam os níveis aumentados de RBP4 com a gravidade do diabetes melito tipo 2 (DM2) e resistência à insulina (RI). O objetivo deste estudo foi investigar como esses níveis se comportam em mulheres com ampla variação do índice de massa corporal (IMC) e tolerância à glicose. Sujeitos e métodos: Estudo transversal realizado com 139 mulheres, divididas em três grupos: Grupo 1 (controles-magras; n = 45) e Grupo 2 (obesas; n = 53), com tolerância normal à glicose; Grupo 3 (obesas DM2; n = 41), denominados G1, G2 e G3. Foram avaliados parâmetros clínicos, bioquímicos, antropométricos e composição corporal. Resultados: De acordo com a análise dos dados, obtivemos em G1 maiores níveis de RBP4 (104,8 ± 76,8 ng/mL) em comparação ao G2 (87,9 ± 38 ng/mL) e G3 (72,2 ± 15,6 ng/mL). Também foram encontradas correlações positivas entre RBP4 e IMC (r = 0,253), hemoglobina glicada (r = 0,378) e insulinemia de jejum (r = 0,336); em G2 com hemoglobina glicada (r = 0,489); G3 com hemoglobina glicada (r = 0,330), insulinemia de jejum (r = 0,463) e HOMA-IR (r = 0,481). Conclusões: Embora a RBP4 tenha apresentado níveis menores em pacientes diabéticas e obesas, a forte correlação com o índice HOMA-IR deixa claro que, em nosso estudo, há crescente RI quando os níveis dessa proteína também são crescentes. Arq Bras Endocrinol Metab. 2014;58(7):709-14 Descritores Obesidade; síndrome metabólica; resistência à insulina; mulheres; pré-menopausa

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“…However, the associations between RBP4 levels and measures of insulin resistance were not consistent. In several studies, lack of association between RBP4 levels and insulin sensitivity was also observed (21)(22)(23). Inconsistency in the methodology of measuring RBP4 might be a major cause.…”

Section: Discussionmentioning

confidence: 88%