Association of Screening Lower Endoscopy With Colorectal Cancer Incidence and Mortality in Adults Older Than 75 Years

Ma, Wenjie; Wang, Kai; Nguyen, Long H.; Joshi, Amit D.; Cao, Yin; Nishihara, Reiko; Wu, Kana; Ogino, Shuji; Giovannucci, Edward; Song, Mingyang; Chan, Andrew T.

doi:10.1001/jamaoncol.2021.1364

Cited by 29 publications

(26 citation statements)

References 28 publications

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“…Individuals with prior negative screening history may have reduced risk, whereas unscreened individuals are at a higher risk for CRC than adequately screened patients. Screening should be initiated for those who have never been screened, even after the age of 75 years for individuals without significant comorbidities[ 43 ].…”

Section: Risk Factors For Developing Crcmentioning

confidence: 99%

Practical considerations for colorectal cancer screening in older adults

Gornick¹,

Kadakuntla²,

Trovato³

et al. 2022

WJGO

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Section: Risk Factors For Developing Crcmentioning

confidence: 99%

Practical considerations for colorectal cancer screening in older adults

Gornick¹,

Kadakuntla²,

Trovato³

et al. 2022

WJGO

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“…This result is consistent with the current ACG and USPSTF clinical guidelines that recommend against routine cancer screening for colorectal cancer in adults aged 76 and older ( Davidson et al, 2021 ). However, clinical studies showed that people who had colorectal cancer screening after age 75 had a lower risk of colorectal cancer and a lower risk of death from colorectal cancer ( Ma et al, 2021 ). Due to this reason, individuals older than 75 years of age may be more likely to get FOBT, which is a noninvasive test and can be performed at home.…”

Section: Discussionmentioning

confidence: 99%

Impact of Alzheimer’s disease and related dementias on colorectal cancer screening utilization, knowledge, and associated health disparities

Wang

Jiang

et al. 2022

Front. Pharmacol.

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Background: Colorectal cancer screening can detect colorectal cancer at an early stage and reduce mortality. None of the existing clinical practice guidelines provide specific recommendations for colorectal cancer screening in patients with Alzheimer’s disease and related dementias (ADRD). Limited studies have assessed the impacts of ADRD on colorectal cancer screening use and knowledge, and no studies have focused on the associated health disparities.Objectives: To examine the utilization, knowledge, and associated health disparities of colorectal cancer screening in older adults with ADRD.Methods: This study used the Medicare Current Beneficiary Survey from 2015 to 2018. Two types of colorectal cancer screening, including fecal occult blood test (FOBT) and colonoscopy/sigmoidoscopy, were measured. The colorectal cancer screening knowledge was evaluated by asking if the participants have heard of two screening methods and whether they knew Medicare pays for colorectal cancer screenings. Logistic regression models were used to examine the impact of ADRD diagnosis on the utilization and knowledge of colorectal cancer screening.Results: The overall colorectal cancer screening rate in older adults increased from 86.4% to 88.96% from 2015 to 2018. Patients with AD were 39% (OR: 0.61; 95% CI: 0.50–0.76) less likely and those with RD were 25% (OR: 0.75; 95% CI: 0.62–0.91) less likely to use any colorectal cancer screening when compared to older adults without ADRD. The rate of knowledge of colonoscopy/sigmoidoscopy remained high between 84.23% and 84.57% while the knowledge of FOBT increased from 64.32% to 78.69% during the study period. Compared to older adults without ADRD, those with AD were 77% (OR: 1.77; 95% CI: 1.12–2.81) more likely to hear of colonoscopy/sigmoidoscopy. The rate of knowledge of Medicare pay for colorectal cancer screening increased from 42.19% to 45.27% during the study period. Compared to older adults without ADRD, those with AD were 19% (OR: 0.81; 95% CI: 0.70–0.94) less likely to know that Medicare pays for colorectal cancer screening.Conclusion: ADRD was significantly associated with colorectal cancer screening utilization and knowledge. In addition, this study identified health disparities in race/ethnicity, gender, and urban/rural residence in colorectal cancer screening use and knowledge.

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“…CRC is usually asymptomatic in the early stages. Symptoms appear in the advanced stages of cancer ( Ma et al., 2021 ). Hematochezia is a warning sign for CRC, but colon bleeding is sometimes very mild and cannot be detected.…”

Section: Discussionmentioning

confidence: 99%

Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent–Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran

Dolatabadi

Fazeli

Karbasizade

et al. 2022

Front. Cell. Infect. Microbiol.

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There is increasing evidence showing that microbial dysbiosis impacts the health and cancer risk of the host. An association between adherent–invasive Escherichia coli (AIEC) and colorectal cancer (CRC) has been revealed. Cyclomodulins (CMs) have been receiving increasing attention for carcinogenic changes. In this study, the incidence and features of intracellular AIEC and cyclomodulin-encoding genes were investigated and the phylogenetic grouping and genetic relatedness were evaluated. E. coli strains were isolated from the colorectal biopsies. Adhesion and invasion assays and intramacrophage cell survival test were performed to separate the AIEC isolates. Virulence genotyping for the genes htrA, dsbA, chuA, and lpfA and the cyclomodulin toxins was also conducted. In addition, phylogenetic grouping of the isolates was determined. Subsequently, repetitive element sequence-based PCR (rep-PCR) fingerprinting was performed. A total of 24 AIEC pathovars were isolated from 150 patients. The prevalence rates of htr, dsbA, and lpfA were 70.83% and that of chuA was 91.66%. The frequencies of the cyclomodulin toxins were as follows: cnf1, 29.2%; cnf2, 25%; colibactin, 29.2%; and cdt, 4.2%; cif was not found. Among the AIEC isolates, 4.2%, 4.2%, 54.2%, 29.2%, and 8.3% with phylotypes A or C, B1, B2, D, and E were identified, respectively. Left-sided colon carcinoma and adenocarcinoma T≥1 stage (CRC2) were colonized by B2 phylogroup AIEC-producing CMs more often than the samples from the other groups. Close genetic relatedness was observed in AIEC isolates with rep-PCR.

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Association of Screening Lower Endoscopy With Colorectal Cancer Incidence and Mortality in Adults Older Than 75 Years

Cited by 29 publications

References 28 publications

Practical considerations for colorectal cancer screening in older adults

Practical considerations for colorectal cancer screening in older adults

Impact of Alzheimer’s disease and related dementias on colorectal cancer screening utilization, knowledge, and associated health disparities

Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent–Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran

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