Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women

Hermsdorff, Helen Hermana Miranda; Zulet, M. Ángeles; Puchau, Blanca; Bressan, Josefina; Martínéz, J. Alfredo

doi:10.1016/j.nut.2008.09.015

Cited by 47 publications

(44 citation statements)

References 60 publications

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“…A recent study [43] evaluated RbP4 regulation by retinoic acid, the carboxylic acid form of vitamin A, in adipose tissues and liver of mice, and reported that alltrans retinoic acid (ATRA) led to a reduction of RbP4 mRnA and protein levels in adipose tissues, and enhanced systemic glucose tolerance and insulin sensitivity of the animals [43,44]. in human, some recent studies provided new evidence that RbP4 concentrations had a positive and significant correlation with daily vitamin A intakes [45]. however, a study [46] in Children reported that total vitamin A intakes, as well as intakes of vitamin A as β-carotene or retinol, did ly correlated with RbP4 in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Serum Retinol-binding Protein 4 is Elevated and Positively Associated with Insulin Resistance in Postmenopausal Women

Wang

Liu

et al. 2009

Endocr J

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Abstract. Retinol-binding protein 4 (RbP4) is a newly discovered adipokine, which is reported to be correlated with insulin resistance (IR) and type 2 diabetes (T2DM). The aim of this study was to evaluate the influence of menopausal status on RbP4 concentration and to investigate serum RbP4 with iR and the prevalence of T2dm in postmenopausal women. We conducted a cross-sectional study and enrolled 34 healthy premenopausal women, 41 healthy postmenopausal women and 37 postmenopausal women with T2dm. Serum RbP4 concentration was measured by an enzyme-linked immunosorbent assay. Anthropometric parameters, plasma glucose, insulin and sex hormones concentrations were measured, and iR was assessed by HOMA2-IR. We found RBP4 was significantly elevated after menopause, even after adjustment for age and BMI. In postmenopausal women, RbP4 correlated positively with bmi, WhR, FPi, homA2-iR, Tg and FAi, while negatively with Shbg (p<0.05). Furthermore, RbP4 was positively associated with 17β-estradiol in only diabetic postmenopausal women. in healthy premenopausal group, age, bmi, and Tg were the independent determinants of RbP4. in two postmenopausal groups, the independent determinants of RBP4 were BMI, WHR, HOMA2-IR, TG and FAI in healthy subjects, and in group with T2dm, the determinants were bmi, WhR, FPi, homA2-iR, Tg and FAi (p<0.05). however, serum RbP4 was not significantly associated with increased odds of T2DM in postmenopausal women (OR 0.979, 95% CI 0.610-1.637). The findings suggested serum RBP4 concentration is influenced by menopausal status and closely related to IR but not to the prevalence of T2dm in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Serum Retinol-binding Protein 4 is Elevated and Positively Associated with Insulin Resistance in Postmenopausal Women

Wang

Liu

et al. 2009

Endocr J

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“…Exclusion criteria included pregnancy, inflammatory, heart and respiratory diseases, hormonal treatments, prescribed drugs that could affect glucose metabolism, alcoholic and drug dependence, recent followup of diets designed for weight loss, or unstable weight in the last 3 months as examined by a phone screening, which was followed by a questionnaire fulfilled by a trained physician. Each volunteer signed a written informed consent, which was previously approved by the Ethics Committee in Human Anthropometry and body fat distribution Anthropometric determinations such as weight, height, waist circumference (WC), hip circumference, and skinfold thicknesses were taken using standard measurement procedures [24,25], as agreed by both universities participating in the study.…”

Section: Subjectsmentioning

confidence: 99%

Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

et al. 2012

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“…Anthropometrical measurements were conducted according to previously described procedures [19]. BMI was calculated by the quotient between weight (kilograms) and the squared height (square meters), which was applied to categorize normal weight (18.5-24.9 kg/m 2 ), overweight (BMI≥25 kg/m 2 ), and obese (BMI≥30 kg/m 2 ) subjects, according to the Spanish Society for Obesity Study criteria [20].…”

Section: Anthropometry and Body Composition Assessmentmentioning

confidence: 99%

Central Adiposity Rather Than Total Adiposity Measurements Are Specifically Involved in the Inflammatory Status from Healthy Young Adults

et al. 2010

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This study assessed the potential association of some proinflammatory markers with adiposity (total vs. central) and metabolic features in young adults. Measurements included body composition, lifestyle features, blood biochemical, and selected inflammatory indicators on 154 healthy subjects (53 M/101 F; 21.5 ± 3 years; 22.1 ± 2.6 kg/m(2)). Those subjects with higher waist circumference (WC) and waist-hip ratio (WHR) showed higher (P < 0.05) C-reactive protein (CRP), complement C3, interleukin-6 (IL6), and retinol binding protein-4 (RBP4) concentrations, while only IL6 was positively associated with total body fat (%). Furthermore, CRP and RBP4 were higher in former/current smokers, as compared to never smokers (P < 0.05). Some indicators of glucose (homeostasis model assessment-insulin resistance) and lipid metabolism (total cholesterol/high density lipoprotein-cholesterol and triglycerides) were positively associated with the assayed inflammatory markers (P < 0.05). The findings of this cross-sectional study indicate that central adiposity-related indicators (WC/WHR) correlated better than those assessing total adiposity with plasma proinflammatory markers, which additionally were associated with lifestyle and metabolic features in healthy young adults.

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Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women

Cited by 47 publications

References 60 publications

Serum Retinol-binding Protein 4 is Elevated and Positively Associated with Insulin Resistance in Postmenopausal Women

Serum Retinol-binding Protein 4 is Elevated and Positively Associated with Insulin Resistance in Postmenopausal Women

Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

Central Adiposity Rather Than Total Adiposity Measurements Are Specifically Involved in the Inflammatory Status from Healthy Young Adults

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