Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (<i>TERT, TRF1, TNKS2</i>) in Laryngeal Squamous Cell Carcinoma

Vaičiulis, Paulius; Liutkevičienė, Rasa; Liutkevičius, Vykintas; Vilkeviciute, Alvita; Gedvilaitė, Greta; Uloza, Virgilijus

doi:10.21873/cgp.20202

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…In recent years, TNKS2 has emerged as potentially useful chemical probe for several cancers. For example, Vaiciulis et al discovered that TNKS2 played crucial roles in laryngeal cancer [ 28 ]. Jumatovaite et al found the participation of TNKS2 in the progression of oral cancer [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

Zheng

2021

World J Surg Onc

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Objective Colorectal cancer is one of the most common malignancy in the world. The oncogenesis of colorectal cancer is still not fully elucidated. It was reported that microRNA-490-3p (miR-490-3p) was closely related to the regulation of cancers. However, if miR-490-3p could also affect colorectal cancer and the specific mechanism remains unclear. Methods qRT-PCR was conducted to examine the expression of miR-490-3p. DIANA, miRDB, and TargetScan databases were used to identify target genes. LOVO and SW480 cells were transfected by miR-490-3p mimics and inhibitors. Transwell assay was used to measure cell invasion and migration. Cisplatin and fluorouracil were administered to investigate chemotherapy resistance. Western blot was used to measure TNKS2 protein expression. Binding sites were verified using the double luciferase assay. Results miR-490-3p expression was low in the colorectal cancer cells. The level of miR-490-3p was negatively correlated with cell migration and invasion of cancer cells. miR-490-3p could bind to TNKS2 mRNA 3′UTR directly. miR-490-3p can suppress cell viability and resistance to chemotherapy in colorectal cancer cells through targeting TNKS2. Conclusions miR-490-3p could affect colorectal cancer by targeting TNKS2. This study may provide a potential therapeutic target for colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

Zheng

2021

World J Surg Onc

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“…It has been suggested that telomeres are shorter in patients with laryngeal squamous cell carcinoma in the tumor differentiation grade 3 group than in the grade 1 and grade 2 groups. The grade 3 subgroup had the worst prognosis, with the highest mortality rate ( 59 ).…”

Section: Laryngeal Cancermentioning

confidence: 99%

Role of telomere length in human carcinogenesis (Review)

et al. 2023

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Cancer is considered the most important clinical, social and economic issue regarding cause-specific disability-adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer-specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer-initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.

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“…Recently, rs8105767 variant within ZNF208 gene has attracted much attention in a genome-wide association study related to its relevance to telomere length ( Alves-Paiva et al, 2019 ). This variant was reported to be related to the risk of glioma and soft tissue sarcoma in a genome-wide association study related to its relevance to telomere length ( Vaiciulis et al, 2020 ; Gabriel et al, 2009 ). Nevertheless, this SNP was not associated with reduced telomere length in squamous cell carcinoma of the head and neck in a Chinese Han population ( Thomas et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…The attention has been increasingly focused on investigations of telomeres and telomere length regulating genes, due to their importance in aging and development of chronic diseases and malignant tumors. Paulius Vaiciulis et al have found the association of relative leucocyte telomere length and gene single nucleotide polymorphisms (TERT, TRF1, and TNKS2) in LC ( Vaiciulis et al, 2020 ). However, the correlation between the gene mutations of telomere length–associated gene ZNF208 and LC remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

et al. 2022

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Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance.Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026).Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.

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Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma

Cited by 9 publications

References 45 publications

MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

Role of telomere length in human carcinogenesis (Review)

Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male

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