2011
DOI: 10.18632/aging.100305
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Abstract: The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors (TCR). Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D). The aim of this study was to analyze a possible association bet… Show more

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Cited by 58 publications
(44 citation statements)
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“…In brief, European populations or populations of European descent showed a higher frequency than other populations, and the frequency in northern Europe was higher than in the south. The highest T allele frequency (17.5%) was reported in northeast Russia, 14 followed by Finland (15.4%), 15 Ukraine (14.1%) 16 and Estonia (13.9%). 17 The frequency decreased toward the west, showing 11-13% in Poland, [18][19][20] 10-12% in Sweden, [21][22][23] Norway [24][25][26] and Germany, 24,[27][28][29] 11.7% in Croatia, 10-11% in the Czech Republic, 30,31 10.7% in Slovakia, 32 9.2% in Denmark, 33 and 8-10% in the UK [34][35][36][37][38][39] and the Netherlands.…”
Section: Frequency Of the Ptpn22 Minor Allelementioning
confidence: 94%
See 1 more Smart Citation
“…In brief, European populations or populations of European descent showed a higher frequency than other populations, and the frequency in northern Europe was higher than in the south. The highest T allele frequency (17.5%) was reported in northeast Russia, 14 followed by Finland (15.4%), 15 Ukraine (14.1%) 16 and Estonia (13.9%). 17 The frequency decreased toward the west, showing 11-13% in Poland, [18][19][20] 10-12% in Sweden, [21][22][23] Norway [24][25][26] and Germany, 24,[27][28][29] 11.7% in Croatia, 10-11% in the Czech Republic, 30,31 10.7% in Slovakia, 32 9.2% in Denmark, 33 and 8-10% in the UK [34][35][36][37][38][39] and the Netherlands.…”
Section: Frequency Of the Ptpn22 Minor Allelementioning
confidence: 94%
“…In total, 36 case-control studies were recruited for the present study with ORs ranging from 0.99 to 2.56. 3,14,15,18,22,24,26,28,32,35,[39][40][41][42]54,60,67,[92][93][94][95][96][97][98][99][100][101][102][103] Thirty-one out of thirty-six showed a significant association between PTPN22 and RA. Meta-analysis showed a strong association between the T allele and RA (OR ¼ 1.65; 95% CI ¼ 1.58-1.71, Po1.00 Â 10 À 16 ) (Figure 2b).…”
mentioning
confidence: 99%
“…The needed DNA for genotyping were extracted from peripheral blood in all studies and the used genotyping methods included the classic polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in eight out of eleven studies. The genotype distributions among the controls of all studies were consistent with HWE except for one study [23].…”
Section: Characteristics Of Studiesmentioning
confidence: 57%
“…Via an extensive search, eleven eligible articles [3,7,[16][17][18][19][20][21][22][23][24] were selected for this meta-analysis, including 3764 AITD cases and 3328 controls. Study characteristics were summarized in Table 1.…”
Section: Characteristics Of Studiesmentioning
confidence: 99%
“…Analysis of defined SNP variations appears to distinguish distinct autoimmune disorders and has a prognostic significance in leukemia and lymphoma. 44,45 This progress is not limited to the investigations of disease phenotypes. Aging and longevity phenotypes in human populations have been associated with multiple SNP variations.…”
Section: Introductionmentioning
confidence: 99%