Association of psoriasis/psoriatic arthritis with inflammatory bowel disease influences management strategy

Shaw, Cassie; Kole, Lauren; Elewski, Boni E.

doi:10.1111/jdv.15752

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Association of psoriasis/PsA with IBD influences management strategy (126), and young patients and those with severe psoriasis may require comprehensive management (127). Time to CD, but not UC, diagnosis was significantly longer for patients with psoriasis compared with the general controls, and patients with systemic treatment had the longest time to CD and UC (122).…”

Section: Gastrointestinal Disease Inflammatory Bowel Diseasesmentioning

confidence: 99%

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

Ding

Zhou

et al. 2022

Front. Immunol.

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Psoriasis is a chronic autoimmune inflammatory disease that remains active for a long period, even for life in most patients. The impact of psoriasis on health is not only limited to the skin, but also influences multiple systems of the body, even mental health. With the increasing of literature on the association between psoriasis and extracutaneous systems, a better understanding of psoriasis as an autoimmune disease with systemic inflammation is created. Except for cardiometabolic diseases, gastrointestinal diseases, chronic kidney diseases, malignancy, and infections that have received much attention, the association between psoriasis and more systemic diseases, including the skin system, reproductive system, and oral and ocular systems has also been revealed, and mental health diseases draw more attention not just because of the negative mental and mood influence caused by skin lesions, but a common immune-inflammatory mechanism identified of the two systemic diseases. This review summarizes the epidemiological evidence supporting the association between psoriasis and important and/or newly reported systemic diseases in the past 5 years, and may help to comprehensively recognize the comorbidity burden related to psoriasis, further to improve the management of people with psoriasis.

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Section: Gastrointestinal Disease Inflammatory Bowel Diseasesmentioning

confidence: 99%

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

Ding

Zhou

et al. 2022

Front. Immunol.

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“…Chang et al confirmed a marked upregulation of the Th17 response, which could have a role in IL17-driven inflammation in psoriasis [112]. A statistically significant association between psoriasis and IBD and another important comorbidity of psoriasis is psoriatic arthritis has been demonstrated [161,162]. The gut microbiota profile of patients with psoriatic arthritis and patients with psoriasis showed decreased bacterial diversity and a reduced abundance of Akkermansia , Ruminococcus and Pseudobutyrivibrio compared to healthy controls, and the microbiota profile of psoriatic arthritis resembled that published for patients with IBD [113].…”

Section: Psoriasismentioning

confidence: 99%

Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes?

et al. 2019

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Several studies highlighted the importance of the interaction between microbiota and the immune system in the development and maintenance of the homeostasis of the human organism. Dysbiosis is associated with proinflammatory and pathological state-like metabolic diseases, autoimmune diseases and HIV infection. In this review, we discuss the current understanding of the possible role of dysbiosis in triggering and/or exacerbating symptoms of autoimmune diseases and HIV infection. There are no data about the influence of the microbiome on the development of autoimmune diseases during HIV infection. We can hypothesize that untreated patients may be more susceptible to the development of autoimmune diseases, due to the presence of dysbiosis. Eubiosis, re-established by probiotic administration, can be used to reduce triggers for autoimmune diseases in untreated HIV patients, although clinical studies are needed to evaluate the role of the microbiome in autoimmune diseases in HIV patients.

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“…We herein present a case previously reported in the literature that underlines the importance of screening for IBD in patients with PsO. [ 3 ] A 53-year-old male with a history of PsO and psoriatic arthritis (PsA), initially well-controlled with secukinumab (on therapy for one year), was incidentally diagnosed with CD on a routine colonoscopy that was performed as part of his age-appropriate cancer screening – CT enterography demonstrated wall thickening, fatty replacement of the wall, and increased enhancement of the mucosa of the distal terminal ileum. The patient was transitioned to ustekinumab given the risk of CD exacerbation with IL-17 inhibition.…”

mentioning

confidence: 94%