Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang

Bai, Linquan; Liu, Zhiqiang; Bakeyi, Maerjiaen; Lü, Wei; He, Pengyi; Yang, Yuchun; Wulasihan, Muhuyati

doi:10.1016/j.bbrc.2014.07.120

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…The occurrence of gene polymorphisms in the sP-selectin gene is linked to elevated serum levels of sP-selectin or a higher risk of thromboembolic events. This implies that individuals with nonvalvular AF and a history of thromboembolic events may have a relevant genetic predisposition [63]. Also, peripheral sP-selectin levels were associated with hypertension before ablation and with persistent AF after ablation [64].…”

Section: P-selectinmentioning

confidence: 99%

The Association between Coagulation and Atrial Fibrillation

Rafaqat,

Gluscevic,

Patoulias

et al. 2024

Biomedicines

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The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels of coagulation factors are associated with both existing and newly diagnosed cases of atrial fibrillation (AF). However, this article summarizes the role of coagulation in the pathogenesis of AF, which includes fibrinogen and fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, plasminogen activator inhibitor-1, and platelet activation. Coagulation irregularities play a significant role in the pathogenesis of AF.

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Section: P-selectinmentioning

confidence: 99%

The Association between Coagulation and Atrial Fibrillation

Rafaqat,

Gluscevic,

Patoulias

et al. 2024

Biomedicines

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Correlation between P-selectin rs1800807 and rs1800808 Gene polymorphisms and plasma soluble P-selectin concentrations in patients with atrial fibrillation complicated with thromboembolism in Xinjiang, China

Hailati²,

Liu³

et al. 2020

Medicine

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This study is to investigate the relationship of P-selectin (Ps) gene rs1800807 and rs1800808 polymorphisms with plasma soluble P-selectin (sPs) in Han, Uygur, and Kazakh people with atrial fibrillation (AF) and thromboembolism (TE) in Xinjiang, China. A total of 778 Han patients (including 131 patients with AF and TE, 229 patients with AF and 418 healthy individuals), 660 Uygur patients (including 118 patients with AF and TE, 232 patients with AF and 310 healthy individuals), and 505 Kazakh patients (including 42 patients with AF and TE, 156 patients with AF and 307 healthy individuals) were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism and direct DNA sequence analysis were used to analyze the polymorphisms of rs1800807 and rs1800808 of Ps gene. ELISA was used to determine the plasma sPs level. The association between plasma sPs levels and Ps gene polymorphisms was further analyzed. The sPs concentrations of GG genotype at rs1800807 locus in the Han, Uygur and Kazakh ethnic groups in Xinjiang, China were significantly higher than those of the CC genotype and CG genotype (P < .05). In the rs1800808 locus, plasma sPs concentrations of the heterozygous mutant CT genotypes in Han and Uygur populations were significantly higher than those in the CC and TT genotypes, whereas the plasma sPs concentrations in Kazakh TT genotypes were significantly higher than those in the CC and CT genotypes (P < .05). Among different ethnic groups, there were significant differences in sPs levels of rs1800807 and rs1800808 genotypes (P < .05). Plasma sPs concentrations are associated with Ps genotypes and sPs concentration of the same genotype shows racial differences.

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Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang

Abstract: The sP-selectin gene polymorphisms are associated with serum sP-selectin levels or thromboembolic events, suggesting that the patients with nonvalvular AF and thromboembolic events may have genetic susceptibility.

Cited by 2 publications

References 14 publications

The Association between Coagulation and Atrial Fibrillation

The Association between Coagulation and Atrial Fibrillation

Correlation between P-selectin rs1800807 and rs1800808 Gene polymorphisms and plasma soluble P-selectin concentrations in patients with atrial fibrillation complicated with thromboembolism in Xinjiang, China

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